(+/-)-2-methoxy-1-(2'-nitrophenyl)naphthalene | 860395-81-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: (+/-)-2-methoxy-1-(2'-nitrophenyl)naphthalene
• 英文别名: 2-methoxy-1-(2-nitrophenyl)naphthalene；methyl-[1-(2-nitro-phenyl)-[2]naphthyl]-ether；Methyl-[1-(2-nitro-phenyl)-[2]naphthyl]-aether
• CAS: 860395-81-9
• 化学式: C₁₇H₁₃NO₃
• 分子量: 279.295
• InChiKey: WXSJEELLWCSERK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.42
• 重原子数：
  21.0
• 可旋转键数：
  3.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  52.37
• 氢给体数：
  0.0
• 氢受体数：
  3.0

反应信息

• 作为反应物：
  描述：

  (+/-)-2-methoxy-1-(2'-nitrophenyl)naphthalene 在 10% palladium on activated carbon 、 一水合肼 作用下， 以 乙醇 为溶剂， 反应 12.0h， 以84%的产率得到1-(2-aminophenyl)-2-methoxynaphthalene
  参考文献：
  名称：

  双功能有机催化剂，用于活化二氧化碳和环氧以产生环状碳酸酯：甜菜碱作为一种新型催化基团

  摘要：

  已经开发了具有甜菜碱铵骨架的双功能有机催化剂，作为用于活化二氧化碳和环氧化物以生产环状碳酸酯的新的催化基序。

  DOI：

  10.1021/ol102539x
• 作为产物：
  描述：

  1-碘-2-甲氧基萘 、 1-溴-2-硝基苯 在 铜 作用下， 生成 (+/-)-2-methoxy-1-(2'-nitrophenyl)naphthalene
  参考文献：
  名称：

  荧光素的合成。第十二部分。荧蒽衍生物的光谱检查

  摘要：

  DOI：

  10.1039/jr9540000227

文献信息

• Studies towards the N-acylative kinetic resolution of NOBIN
  作者：Stellios Arseniyadis、Mohan Mahesh、Paul McDaid、Thomas Hampel、Stephen G. Davey、Alan C. Spivey

  DOI：10.1135/cccc2011034

  日期：——

  An investigation into the N-acylation of atropisomeric anilines 8 and 2, which are related to NOBIN (1), catalysed by small molecule chiral pyridine-based nucleophilic catalysts is described. The first organocatalytic kinetic resolution (KR) of an atropisomeric aniline is described.

  描述了对与NOBIN相关的具有异构体结构的苯胺8和2的N-酰化的研究，该过程由小分子手性吡啶基亲核催化剂催化。描述了第一个有机催化动力学分辨（KR）的异构体苯胺。
• Bis(2-alkylpyrrolidin-1-yl)methylidenes as Chiral Acyclic Diaminocarbene Ligands
  作者：David R. Snead、Sebastien Inagaki、Khalil A. Abboud、Sukwon Hong

  DOI：10.1021/om901112n

  日期：2010.4.12

  2-Alkylpyrrolidines were used as building blocks for acyclic diaminocarbenes (ADCs). First, ureas were made from the corresponding amines, and then the urns were converted to chloro-amidiniums. The chloroamidiniums served as direct precursors to ADCs, and palladium complexes were made utilizing oxidative addition, whereas lithium halogen exchange was performed to generate rhodium complexes. The carbene ligands were characterized through use of NMR, mass spectrometry, and X-ray analysis, and from X-ray structures, steric parameters were calculated as % V-Bur values. The ability of these ligands to direct stereochemistry and enhance activity was explored in the Suzuki cross-coupling reaction and the 1,2 addition of arylboronic acids to aldehydes.