bis(salicylaldehyde) S-methylisothiosemicarbazone | 59004-63-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: bis(salicylaldehyde) S-methylisothiosemicarbazone
• CAS: 59004-63-6
• 化学式: C₁₆H₁₅N₃O₂S
• 分子量: 313.38
• InChiKey: RBICWWDPWJHOOV-UHFFFAOYSA-N

物化性质

• 熔点：
  160-161 °C
• 沸点：
  510.3±60.0 °C(Predicted)
• 密度：
  1.34 g/cm3

反应信息

• 作为反应物：
  描述：

  [tris(triphenylphosphine) ruthenium(III) trichloride] 、 bis(salicylaldehyde) S-methylisothiosemicarbazone 以 苯 为溶剂， 反应 6.0h， 以61%的产率得到
  参考文献：
  名称：

  Ruthenium(III) S-methylisothiosemicarbazone Schiff base complexes bearing PPh3/AsPh3 coligand: Synthesis, structure and biological investigations, including antioxidant, DNA and protein interaction, and in vitro anticancer activities

  摘要：

  New Ru(III) isothiosemicarbazone complexes [RuCl(EPh3)L(1-4)] (E=P or As) were obtained from the reactions between [RuCl3(EPh3)3] and bis(salicylaldehyde)-S-methylisothiosemicarbazone (H2L(1-3))/bis(2-hydroxy-naphthaldehyde)-S-methylisothiosemicarbazone (H2L(4)) ligands. The new complexes were characterized by using elemental analyses and various spectral (UV-Vis, IR, (1)H NMR, FAB-Mass and EPR) methods. The redox properties of the complexes were studied by using cyclic voltammetric method. The new complexes were subjected to various biological investigations such as antioxidant assays involving DPPH radical, hydroxyl radical, nitric oxide radical and hydrogen peroxide, DNA/protein interaction studies and in vitro cytotoxic studies against human breast cancer cell line (MCF-7). New complexes showed excellent free radicals scavenging ability and could bind with DNA via intercalation. Protein binding studies using fluorescence spectroscopy showed that the new complexes could bind strongly with bovine serum albumin (BSA). Photo cleavage experiments using DNA of E-coli bacterium exhibited the DNA cleavage ability of the complexes. Further, the in vitro anticancer activity studies on the new complexes against MCF-7 cell line exhibited the ability of Ru(III) isothiosemicarbazone complexes to suppress the development of malignant neoplastic disease cells.

  DOI：

  10.1016/j.jphotobiol.2014.04.019
• 作为产物：
  描述：

  水杨醛 、 S-甲基异硫氨基脲盐酸盐 以 乙醇 为溶剂， 生成 bis(salicylaldehyde) S-methylisothiosemicarbazone
  参考文献：
  名称：

  Ruthenium(III) S-methylisothiosemicarbazone Schiff base complexes bearing PPh3/AsPh3 coligand: Synthesis, structure and biological investigations, including antioxidant, DNA and protein interaction, and in vitro anticancer activities

  摘要：

  New Ru(III) isothiosemicarbazone complexes [RuCl(EPh3)L(1-4)] (E=P or As) were obtained from the reactions between [RuCl3(EPh3)3] and bis(salicylaldehyde)-S-methylisothiosemicarbazone (H2L(1-3))/bis(2-hydroxy-naphthaldehyde)-S-methylisothiosemicarbazone (H2L(4)) ligands. The new complexes were characterized by using elemental analyses and various spectral (UV-Vis, IR, (1)H NMR, FAB-Mass and EPR) methods. The redox properties of the complexes were studied by using cyclic voltammetric method. The new complexes were subjected to various biological investigations such as antioxidant assays involving DPPH radical, hydroxyl radical, nitric oxide radical and hydrogen peroxide, DNA/protein interaction studies and in vitro cytotoxic studies against human breast cancer cell line (MCF-7). New complexes showed excellent free radicals scavenging ability and could bind with DNA via intercalation. Protein binding studies using fluorescence spectroscopy showed that the new complexes could bind strongly with bovine serum albumin (BSA). Photo cleavage experiments using DNA of E-coli bacterium exhibited the DNA cleavage ability of the complexes. Further, the in vitro anticancer activity studies on the new complexes against MCF-7 cell line exhibited the ability of Ru(III) isothiosemicarbazone complexes to suppress the development of malignant neoplastic disease cells.

  DOI：

  10.1016/j.jphotobiol.2014.04.019