Phthalsaeure-mono-(3-methyl-pent-3-yl)-ester | 97441-38-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Phthalsaeure-mono-(3-methyl-pent-3-yl)-ester
• 英文别名: 2-(3-Methylpentan-3-yloxycarbonyl)benzoic acid
• CAS: 97441-38-8
• 化学式: C₁₄H₁₈O₄
• 分子量: 250.295
• InChiKey: UHVXQFSBQFICEC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  18
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  63.6
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• TAXOL DRUG COMPOSITION AND PHARMACEUTIC PREPARATION, PREPARATION METHOD THEREFOR AND USE THEREOF
  申请人：Sinotherapeutics Inc.

  公开号：EP3412286A1

  公开（公告）日：2018-12-12

  The present invention relates to a paclitaxel pharmaceutic composition and a pharmaceutic preparation, a preparation process therefor and use thereof. The paclitaxel composition comprises paclitaxel as an active ingredient and hydroxypropyl methyl cellulose derivative as a carrier material. The paclitaxel preparation is in the form of an oral solid preparation. The paclitaxel composition and pharmaceutic preparation thereof can be used for the preparation of a drug for preventing and treating malignancies and relevant diseases in mammals.

  本发明涉及一种紫杉醇药物组合物和药物制剂、其制备工艺及其用途。紫杉醇组合物包括作为活性成分的紫杉醇和作为载体材料的羟丙基甲基纤维素衍生物。紫杉醇制剂为口服固体制剂。该紫杉醇组合物及其药物制剂可用于制备预防和治疗哺乳动物恶性肿瘤及相关疾病的药物。
• Paclitaxel pharmaceutical composition and pharmaceutical preparation thereof, preparation process and use thereof
  申请人：Sinotherapeutics Inc.

  公开号：US10940135B2

  公开（公告）日：2021-03-09

  A paclitaxel pharmaceutic composition and a pharmaceutic preparation, a preparation process therefor and use thereof are provided. The paclitaxel composition contains paclitaxel as an active ingredient and hydroxypropyl methyl cellulose derivative as a carrier material. The paclitaxel preparation is in the form of an oral solid preparation. The paclitaxel composition and pharmaceutic preparation thereof can be used for the preparation of a drug for preventing and treating malignancies and relevant diseases in mammals.

  本发明提供了一种紫杉醇药物组合物和一种药物制剂、其制备工艺及其用途。该紫杉醇组合物含有作为活性成分的紫杉醇和作为载体材料的羟丙基甲基纤维素衍生物。紫杉醇制剂为口服固体制剂。该紫杉醇组合物及其药物制剂可用于制备预防和治疗哺乳动物恶性肿瘤及相关疾病的药物。
• PACLITAXEL PHARMACEUTICAL COMPOSITION AND PHARMACEUTICAL PREPARATION THEREOF, PREPARATION PROCESS AND USE THEREOF
  申请人：Sinotherapeutics Inc.

  公开号：US20190038592A1

  公开（公告）日：2019-02-07

  A paclitaxel pharmaceutic composition and a pharmaceutic preparation, a preparation process therefor and use thereof are provided. The paclitaxel composition contains paclitaxel as an active ingredient and hydroxypropyl methyl cellulose derivative as a carrier material. The paclitaxel preparation is in the form of an oral solid preparation. The paclitaxel composition and pharmaceutic preparation thereof can be used for the preparation of a drug for preventing and treating malignancies and relevant diseases in mammals.