(2R,3R)-2-anilinooxy-3-[tert-butyl(dimethyl)silyl]oxyoctadecan-1-ol | 1360074-42-5

• 分子结构分类: 有机化合物 - 苯类化合物 - N-苯基羟胺
• 英文名称: (2R,3R)-2-anilinooxy-3-[tert-butyl(dimethyl)silyl]oxyoctadecan-1-ol
• CAS: 1360074-42-5
• 化学式: C₃₀H₅₇NO₃Si
• 分子量: 507.873
• InChiKey: XOCMTTBYENCOBP-FQLXRVMXSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  9.26
• 重原子数：
  35
• 可旋转键数：
  22
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  50.7
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  在 sodium tetrahydroborate 作用下， 以 乙醇 、 乙腈 为溶剂， 反应 0.5h， 生成 (2R,3R)-2-anilinooxy-3-[tert-butyl(dimethyl)silyl]oxyoctadecan-1-ol
  参考文献：
  名称：

  Synthesis of chiral 1,2,3-triols via organocatalyzed α-hydroxylation of protected β-hydroxyaldehydes

  摘要：

  Protected 1,2,3-triols were prepared by organocatalytic alpha-hydroxylation of beta-hydroxyaldehydes followed by in situ reduction. All diastereoisomers were obtained with correct yields and good to excellent de. The absolute configurations of the new asymmetric centers were confirmed by derivatization into the corresponding epoxide. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2011.12.078

文献信息

• Synthesis of chiral 1,2,3-triols via organocatalyzed α-hydroxylation of protected β-hydroxyaldehydes
  作者：Olivier Colin、Philippe Hermange、Christine Thomassigny、Christine Greck

  DOI：10.1016/j.tetlet.2011.12.078

  日期：2012.2

  Protected 1,2,3-triols were prepared by organocatalytic alpha-hydroxylation of beta-hydroxyaldehydes followed by in situ reduction. All diastereoisomers were obtained with correct yields and good to excellent de. The absolute configurations of the new asymmetric centers were confirmed by derivatization into the corresponding epoxide. (C) 2012 Elsevier Ltd. All rights reserved.