adamantyl hydrogen(4-iodophenyl)phosphinate | 1619925-56-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: adamantyl hydrogen(4-iodophenyl)phosphinate
• 英文别名: 1-[(4-Iodophenyl)-oxidophosphaniumyl]oxyadamantane
• CAS: 1619925-56-2
• 化学式: C₁₆H₂₀IO₂P
• 分子量: 402.212
• InChiKey: BFFDCMHPGSMUGJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  20
• 可旋转键数：
  3
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  32.3
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• H-Adamantylphosphinates as Universal Precursors of P-Stereogenic Compounds
  作者：David Gatineau、Duc Hanh Nguyen、Damien Hérault、Nicolas Vanthuyne、Julien Leclaire、Laurent Giordano、Gérard Buono

  DOI：10.1021/acs.joc.5b00548

  日期：2015.4.17

  A new family of H-adamantylphosphinates as universal precursors of P-stereogenic ligands was obtained in one step from commercial chlorophosphines. Both enantiomers of these air- and moisture-stable intermediates can easily be separated by semipreparative chiral HPLC on a gram scale and individually undergo stereoselective transformations to afford each enantiomer of a set of P-stereogenic compounds such as secondary phosphine oxides and boron-protected monophosphines.