4-(2-methylpropyl)imidazolidin-2-one | 1267215-69-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑烷类
• 英文名称: 4-(2-methylpropyl)imidazolidin-2-one
• CAS: 1267215-69-9
• 化学式: C₇H₁₄N₂O
• 分子量: 142.201
• InChiKey: SHOWLEQMECNERS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  10
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  41.1
• 氢给体数：
  2
• 氢受体数：
  1

文献信息

• [EN] 2-OXO-1-IMIDAZOLIDINYL IMIDAZOTHIADIAZOLE DERIVATIVES<br/>[FR] DÉRIVÉS DE 2-OXO-1-IMIDAZOLIDINYL IMIDAZOTHIADIAZOLE
  申请人：UCB PHARMA SA

  公开号：WO2012143117A1

  公开（公告）日：2012-10-26

  The present invention relates to 2-oxo-1-imidazolidinyl imidazothiadiazole derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals.

  这项发明涉及2-氧代-1-咪唑啉基咪唑噻二唑衍生物，其制备方法，含有它们的药物组合物以及它们作为药物的用途。
• 2-Oxo-1-Imidazolidinyl Imidazothiadiazole Derivatives
  申请人：Provins Laurent

  公开号：US20140148489A1

  公开（公告）日：2014-05-29

  The present invention relates to 2-oxo-1-imidazolidinyl imidazothiadiazole derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals.

  本发明涉及2-氧代-1-咪唑烷基咪唑硫二唑衍生物，其制备方法，含有它们的药物组合物以及它们作为药物的用途。
• SUBSTITUTED 4-PHENOXYPHENOL ANALOGS AS MODULATORS OF PROLIFERATING CELL NUCLEAR ANTIGEN ACTIVITY
  申请人：Fujii Naoaki

  公开号：US20140288077A1

  公开（公告）日：2014-09-25

  In one aspect, the invention relates to substituted 4-phenoxyphenol analogs, derivatives thereof, and related compounds, which are useful as inhibitors of proliferating cell nuclear antigen (PCNA); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating hyperproliferative disorders associated with PCNA using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

  本发明涉及替代的4-苯氧基苯酚类似物、其衍生物和相关化合物，它们可用作增殖细胞核抗原（PCNA）的抑制剂；制备这些化合物的合成方法；包含这些化合物的制药组合物；以及使用这些化合物和组合物治疗与PCNA相关的高增殖性疾病的方法。本摘要旨在作为搜索特定领域的扫描工具，不限制本发明。
• NAPHTHYRIDINE DERIVATIVES AS POTASSIUM CHANNEL MODULATORS
  申请人：VERNIER JEAN-MICHEL

  公开号：US20090170885A1

  公开（公告）日：2009-07-02

  This invention provided compounds of formula I where W and Z are, independently, CH or N, and where other substituents are defined herein. Such compounds are potassium channel modulators. The invention also provides a composition comprising a pharmaceutically acceptable carrier or excipient and at least one of the following: a pharmaceutically effective amount of a compound of formula I; a pharmaceutically acceptable salt of a compound of formula I; a pharmaceutically acceptable ester of a compound of formula I. The invention also provides a method of preventing or treating a disease or disorder which is affected by activities of potassium channels, comprising administering to a patient in need thereof a therapeutically effective amount of a compound of formula I or a salt or ester or solvate thereof.

  该发明提供了化合物I的公式，其中W和Z独立地为CH或N，其他取代基在此定义。这些化合物是钾通道调节剂。该发明还提供了一种组合物，包括药学上可接受的载体或赋形剂，以及以下至少一种：化合物I的药学有效量；化合物I的药学上可接受的盐；化合物I的药学上可接受的酯。该发明还提供了一种预防或治疗受钾通道活性影响的疾病或疾病的方法，包括向需要治疗的患者施用化合物I或其盐或酯或溶剂的治疗有效量。
• 2-OXO-1-IMIDAZOLIDINYL IMIDAZOTHIADIAZOLE DERIVATIVES
  申请人：UCB Biopharma SPRL

  公开号：EP2699581B1

  公开（公告）日：2015-11-25