4-(4,5-二甲氧基-2-硝基苯基)-1,4-二氢-2,6-二甲基吡啶-3,5-二羧酸二乙酯 | 21203-88-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 4-(4,5-二甲氧基-2-硝基苯基)-1,4-二氢-2,6-二甲基吡啶-3,5-二羧酸二乙酯
• 英文名称: 4-(4,5-dimethoxy-2-nitrophenyl)-2,6-dimethyl-3,5-dicarbethoxy-1,4-dihydropyridine
• 英文别名: 3,5-Diethoxycarbonyl-1,4-dihydro-2,6-dimethyl-4-(4,5-dimethoxy-2-nitro-phenyl)-pyridin；4-(4,5-dimethoxy-2-nitro-phenyl)-2,6-dimethyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid diethyl ester；4-(4,5-Dimethoxy-2-nitro-phenyl)-2,6-dimethyl-1,4-dihydro-pyridin-3,5-dicarbonsaeure-diaethylester；diethyl 4-(4,5-dimethoxy-2-nitrophenyl)-1,4-dihydro-2,6-dimethylpyridine-3,5-dicarboxylate；diethyl 4-(4,5-dimethoxy-2-nitrophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate
• CAS: 21203-88-3
• 化学式: C₂₁H₂₆N₂O₈
• 分子量: 434.446
• InChiKey: DEVHMZKJIJMPBI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  31
• 可旋转键数：
  9
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  129
• 氢给体数：
  1
• 氢受体数：
  9

反应信息

• 作为产物：
  描述：

  乙酰乙酸乙酯 、 6-硝基藜芦醛 在 乙醇 、 氨 作用下， 生成 4-(4,5-二甲氧基-2-硝基苯基)-1,4-二氢-2,6-二甲基吡啶-3,5-二羧酸二乙酯
  参考文献：
  名称：

  Hinkel et al., Journal of the Chemical Society, 1935, p. 816

  摘要：

  DOI：

文献信息

• Medical bathing device
  申请人：BSN Medical GmbH

  公开号：US10813831B2

  公开（公告）日：2020-10-27

  The present invention relates to a medical bathing equipment for the manufacture and use of a bathing solution containing an active substance and in particular a bathing solution containing NO. The invention also relates to a bathing equipment based on a multi-stage method for generating NO and the bathing equipment in its use for the treatment of diseases, in particular of diabetically caused circulatory disorders and wounds of the lower extremities.

  本发明涉及一种医用沐浴设备，用于制造和使用含有活性物质的沐浴液，特别是含有 NO 的沐浴液。本发明还涉及一种基于多级生成 NO 方法的沐浴设备，以及该沐浴设备在治疗疾病，特别是糖尿病引起的循环障碍和下肢伤口方面的用途。
• Photoactivatable coating composition
  申请人：——

  公开号：US20020032248A1

  公开（公告）日：2002-03-14

  Photoactivatable coating composition comprising at least one photoinitiator and a base-catalysed polymerisable or curable organic material comprising at least one polyisocyanate and at least one compound containing isocyanate reactive groups, wherein the isocyanate reactive groups comprise at least one thiol group and the photoinitiator is a photolatent base. Preference is given to a coating composition wherein the photolatent base is selected from the group of N-substituted 4-(ortho-nitrophenyl) dihydropyridine, a quaternary organo-boron photoinitiator, and an &agr;-amino acetophenone. The composition additionally may comprise an organic acid, a metal complex and/or a metal salt as a cocatalyst and/or a sensitiser selected from the group of thioxanthones, oxazines, rhodamines, and preferably from the group of benzo-phenone and derivatives thereof.

  可光活化涂料组合物，包括至少一种光引发剂和一种由至少一种多异氰酸酯和至少一种含有异氰酸酯活性基团的化合物组成的碱催化可聚合或可固化有机材料，其中异氰酸酯活性基团包括至少一个硫醇基团，光引发剂为光惰性碱。 优先考虑的是一种涂料组合物，其中的光合碱选自 N-取代的 4-（邻硝基苯基）二氢吡啶、季铵有机硼光引发剂和氨基苯乙酮。此外，该组合物还可包括一种有机酸、一种金属络合物和/或一种金属盐，作为催化 剂和/或增感剂，它们选自硫杂蒽酮类、噁嗪类、罗丹明类，最好选自苯甲酮及其衍生物类。
• A Novel 4-(4,5-dimethoxy-2-nitrophenyl)-2,6-dimethyl-3,5-dicarbethoxy-1,4-dihydropyridine (C₂₁H₂₆N₂O₈): Microwave-Irradiated Hantzsch Ester Synthesis, Characterization and Molecular Crystal
  作者：Minaxi S. Maru、Manish K. Shah

  DOI：10.1080/15421406.2015.1010907

  日期：2015.12.12

  The novel 4-(4,5-dimethoxy-2-nitrophenyl)-2,6-dimethyl-3,5-dicarbethoxy-1,4-dihydropyridine was synthesized through multicomponent one pot Hantzsch ester synthesis using 4,5-dimethoxy-2-nitrobenzaldehyde, ethyl 3-oxobutanoate, and ammonium carbonate under microwave irradiation and subsequently characterized by several spectroscopic techniques, i.e., ESI mass, IR, H-1, and C-13 NMR along with single crystal X-ray diffraction method. The single crystal of 4-(4,5-dimethoxy-2-nitrophenyl)-2,6-dimethyl-3,5-dicarbethoxy-1,4-dihydropyridine (C21H26N2O8) was developed in 0.35 x 0.30 x 0.25 mm dimension in methanol. The crystal structure parades only intermolecular hydrogen bonding of the N(2)-H(2A)center dot center dot center dot O(2) type and the boat conformation of the dihydropyridine ring.
• PHOTOACTIVATABLE COATING COMPOSITION
  申请人：Akzo Nobel Coatings International B.V.

  公开号：EP1285012B1

  公开（公告）日：2007-01-10
• COATING COMPOSITION BASED ON THIOL-NCO CURING
  申请人：Akzo Nobel Coatings International BV

  公开号：EP1789464B1

  公开（公告）日：2008-11-05