2-(neopentylthio)phenol | 1128193-73-6

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醚类
• 英文名称: 2-(neopentylthio)phenol
• 英文别名: 2-(2,2-dimethylpropylsulfanyl)phenol
• CAS: 1128193-73-6
• 化学式: C₁₁H₁₆OS
• 分子量: 196.313
• InChiKey: HMKIYWSOUGWGLC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  45.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  2-羟基苯硫酚 、 新戊基碘 、 生成 2-(neopentylthio)phenol
  参考文献：
  名称：

  Insecticidal carbamates exhibiting species-selective inhibition of acetylcholinesterase (AChE)

  摘要：

  本发明包括昆虫杀虫剂卡巴酯，例如用于控制蚊子等昆虫的杀虫剂，可用于可能接触或接触人类的应用中。本发明的杀虫剂包括苯基N-甲基卡巴酯和包含它们的组合物，这些组合物表现出对乙酰胆碱酯酶（AChE）的物种选择性抑制，并且最好对蚊子有毒但对人类无害。特别感兴趣的是公式（I）和公式（II）的化合物：公式（I）和公式（II）的化合物特别适用于杀虫剂处理的网和室内残留喷雾，用于蚊子控制。

  公开号：

  US08618162B2

文献信息

• [EN] INHIBITORS OF ALPHA-AMINO-BETA-CARBOXYMUCONIC ACID SEMIALDEHYDE DECARBOXYLASE<br/>[FR] INHIBITEURS DE LA SEMIALDÉHYDE DÉCARBOXYLASE DE L'ACIDE ALPHA-AMINO-BÊTA-CARBOXYMUCONIQUE
  申请人：TES PHARMA S R L

  公开号：WO2018069532A1

  公开（公告）日：2018-04-19

  The present disclosure discloses compounds capable of modulating the activity of α- amino-β-carboxymuconic acid semialdehyde decarboxylase (ACMSD), which are useful for the prevention and/or the treatment of diseases and disorders associated with defects in NAD+ biosynthesis, e.g., metabolic disorders, neurodegenerative diseases, chronic inflammatory diseases, kidney diseases, and diseases associated with ageing. The present application also discloses pharmaceutical compositions comprising said compounds and the use of such compounds as a medicament.

  本公开揭示了能够调节α-氨基-β-羧基琥珀酸半醛脱羧酶（ACMSD）活性的化合物，这些化合物对于预防和/或治疗与NAD+生物合成缺陷相关的疾病和疾病非常有用，例如代谢紊乱、神经退行性疾病、慢性炎症性疾病、肾脏疾病以及与衰老相关的疾病。本申请还揭示了包含所述化合物的药物组合物以及将这些化合物用作药物的用途。
• INSECTICIDAL CARBAMATES EXHIBITING SPECIES-SELECTIVE INHIBITION OF ACETYLCHOLINESTERASE (AChE)
  申请人：Carlier Paul

  公开号：US20090068242A1

  公开（公告）日：2009-03-12

  The present invention includes insecticidal carbamates that are useful, for example, for the control of insects, such as mosquitoes, which can be used in applications where exposure to and/or contact with humans is likely. The insecticides of the present invention include phenyl N-methyl carbamates and compositions comprising them that exhibit species-selective inhibition of acetylcholinesterase (AChE) and are preferably toxic to mosquitoes but not humans. Of particular interest are compounds of Formula (I) and Formula (II): Compounds of Formula (I) and Formula (II) are especially suitable for insecticide treated nets and indoor residual spraying for mosquito control.

  本发明包括杀虫卡巴胺，例如，用于控制昆虫，如蚊子，可用于在可能接触到人类的应用中。本发明的杀虫剂包括苯基N-甲基卡巴胺和包含它们的组合物，这些组合物表现出对乙酰胆碱酯酶（AChE）的物种选择性抑制，并且最好对蚊子有毒而对人类无毒。特别感兴趣的是Formula（I）和Formula（II）的化合物：Formula（I）和Formula（II）的化合物特别适用于杀虫剂处理的蚊帐和室内残留喷雾用于蚊子控制。
• INHIBITORS OF ALPHA-AMINO-BETA-CARBOXYMUCONIC ACID SEMIALDEHYDE DECARBOXYLASE
  申请人：TES Pharma S.r.I.

  公开号：US20180134667A1

  公开（公告）日：2018-05-17

  The present disclosure discloses compounds capable of modulating the activity of α-amino-β-carboxymuconic acid semialdehyde decarboxylase (ACMSD), which are useful for the prevention and/or the treatment of diseases and disorders associated with defects in NAD + biosynthesis, e.g., metabolic disorders, neurodegenerative diseases, chronic inflammatory diseases, kidney diseases, and diseases associated with ageing. The present application also discloses pharmaceutical compositions comprising said compounds and the use of such compounds as a medicament.
• US8129428B2
  申请人：——

  公开号：US8129428B2

  公开（公告）日：2012-03-06
• US8618162B2
  申请人：——

  公开号：US8618162B2

  公开（公告）日：2013-12-31