5-[4-[1-(Benzyloxycarbonyl)piperidin-4-yloxy]phenyl methyl] thiazolidine-2,4-dione | 199103-09-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 5-[4-[1-(Benzyloxycarbonyl)piperidin-4-yloxy]phenyl methyl] thiazolidine-2,4-dione
• 英文别名: 5-[4-[1-(Benzyloxycarbonyl)piperidin-4-yloxy]phenyl methyl]thiazolidine-2,4-dione；benzyl 4-[4-[(2,4-dioxo-1,3-thiazolidin-5-yl)methyl]phenoxy]piperidine-1-carboxylate
• CAS: 199103-09-8
• 化学式: C₂₃H₂₄N₂O₅S
• 分子量: 440.52
• InChiKey: JJCJVYPESOZAHB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  31
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  110
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  5-[4-[1(benzyloxycarbonyl)piperidin-4-yloxy]phenyl methylene]thiazolidine-2,4-dione 在 magnesium 、 盐酸 作用下， 以 甲醇 、 水 为溶剂， 反应 1.0h， 以68%的产率得到5-[4-[1-(Benzyloxycarbonyl)piperidin-4-yloxy]phenyl methyl] thiazolidine-2,4-dione
  参考文献：
  名称：

  NOVEL ANTIDIABETIC COMPOUNDS HAVING HYPOLIPIDAEMIC, ANTIHYPERTENSIVE PROPERTIES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

  摘要：

  公开号：

  EP0981526B1

文献信息

• Antidiabetic compounds having hypolipidaemic, antihypertensive
  申请人：Reddy's Research Foundation

  公开号：US05889025A1

  公开（公告）日：1999-03-30

  Novel antidiabetic compounds, their tautomeric forms, their derivatives, their steroisomers, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates and pharmaceutical acceptable compositions containing them: Methods for preparing the antidiabetic compounds and their uses.

  小说抗糖尿病化合物，它们的互变异构体，它们的衍生物，它们的立体异构体，它们的多晶形态，它们的药物可接受盐，它们的药物可接受溶剂和含有它们的药物可接受组合物：制备抗糖尿病化合物的方法及其用途。
• [EN] NOVEL ANTIDIABETIC COMPOUNDS HAVING HYPOLIPIDAEMIC, ANTIHYPERTENSIVE PROPERTIES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM<br/>[FR] NOUVEAUX COMPOSES ANTI-DIABETIQUES AVEC PROPRIETES HYPOLIPIDEMIANTES ET ANTI-HYPERTENSIVES, PROCEDE POUR LES PREPARER ET COMPOSITIONS PHARMACEUTIQUES CONTENANT CES COMPOSES
  申请人：DR. REDDY'S RESEARCH FOUNDATION

  公开号：WO1997041119A1

  公开（公告）日：1997-11-06

  (EN) New thiazolidin-2,4-dione derivatives of formula (1) in which A, W, Q, B, D, X, Y, Z, R', k and p are defined as in claim 1; their tautomeric forms, their derivatives, their steroisomers, their polymorphs, their pharmaceutical acceptable salts, their pharmaceutically acceptable solvates and pharmaceutically acceptable compositions containing them. Methods for their preparation and their use as antidiabetic compounds are claimed.(FR) Nouveaux dérivés thiazolidin-2,4-dione définis par la formule (I): dans laquelle A,W,Q,B,D,X,Y,Z,R', k et p possèdent les notations indiquées dans la revendication 1, leurs formes tautomériques, leurs dérivés, leurs stéro-isomères, leurs formes polymorphes, les sels et les solvates acceptables sur le plan pharmaceutique de ces composés, et les compositions acceptables sur le plan pharmaceutique les contenant. Procédés de préparation de ces composés et leur utilisation en tant qu'anti-diabétiques.