N-(2-ethoxyethyl)benzamide | 149733-22-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-(2-ethoxyethyl)benzamide
• 英文别名: N-Aethoxyaethylbenzamid
• CAS: 149733-22-2
• 化学式: C₁₁H₁₅NO₂
• 分子量: 193.246
• InChiKey: NTIPIFQPQPHVLZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  14
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  38.3
• 氢给体数：
  1
• 氢受体数：
  2

安全信息

• 危险性防范说明：
  P264,P280,P302+P352,P337+P313,P305+P351+P338,P362+P364,P332+P313
• 危险性描述：
  H315,H319

反应信息

• 作为产物：
  描述：

  S,S-diphenyl-N-(2-ethoxyethyl)sulfilimine 、 alkaline earth salt of/the/ methylsulfuric acid 在 氧气 作用下， 生成 N-(2-ethoxyethyl)benzamide
  参考文献：
  名称：

  Reaction of chromium (Fischer) carbenes and sulfilimines

  摘要：

  The photochemical reactions of alkoxychromium (Fischer) carbenes and sulfilimines lead to imidates in fair to excellent yields. Aromatic, heteroaromatic, and alkylsulfilimines, the latter bearing functional groups such as cyano, sulfone, ether, ester, and dioxolane groups, gave the corresponding imidates in good to excellent yield. However, acyl- and sulfonyl-substituted sulfilimines did not react with chromium carbenes, except for sulfilimines bearing ethoxycarbonyl and phtalimidylamino groups. A variety of differently substituted chromium carbene complexes bearing alkyl, cycloalkyl, styryl, allyl, and alkynyl groups attached either at the carbene carbon or at the oxygen also gave imidates in good yields. For alpha,beta-unsaturated carbenes, the exclusive 1,2-addition of the sulfilimine nitrogen was observed at room temperature, in contrast to the behavior of other nitrogen nucleophiles which are reported to add in 1,4-fashion under these reaction conditions. In turn, optically active imidates of the type ArN=C(OR*)Me [R* = chiral substituent derived from (R)-(+)-1-phenyl-1-butanol, l-(-)-menthol, (1S)-endo-(-)-borneol, and (1R)-(-)-myrtenol] can be prepared efficiently by utilizing the corresponding chiral alkoxy group on the earbene moiety. The reactions above also occur in the dark but reaction times are considerably longer. N-Halosulfilimines reacted with alkoxychromium carbenes to yield N-acylsulfilimines instead of the expected N-haloimidates. Based upon a set of thermal and photochemical reactions between N-haloimidates and diphenyl sulfide in the absence of chromium complexes, the complex (CO)5CrNCMe is proposed to be responsible for this novel reaction of N-haloimidates and diphenyl sulfide.

  DOI：

  10.1021/jo00067a020

文献信息

• Pyrazole compounds and their use as antidiabetes agents
  申请人：Takagi Masaki

  公开号：US20070032529A1

  公开（公告）日：2007-02-08

  The present invention provides a pyrazole compound that has liver glycogen phosphorylase inhibitory activity and is useful as a therapeutic or prophylactic agent for diabetes, the pyrazole compound represented by the following general formula (I): wherein Ring Q represents an aryl or heteroaromatic group, R 1 represents a hydrogen atom, a halogen atom, a C 1-6 alkyl group or a C 1-6 alkoxy group, R 2 represents a halogen atom, a C 1-6 alkyl group, a C 1-6 alkoxy group or an azido group, R 3 represents a halogen atom, a hydroxyl group, a C 1-6 alkyl group, a halo C 1-6 alkyl group, a C 1-6 alkoxy group, an azido group, an amino group, an acylamino group or a C 1-6 alkylsulfonylamino group, R 4 and R 5 are identical with or different from each other and represent a hydrogen atom, a substituted or unsubstituted C 1-6 alkyl group, a C 3-8 cycloalkyl group, a substituted or unsubstituted saturated heterocyclic group, a substituted or unsubstituted aryl group, a C 7-14 aralkyl group, a heteroaromatic group, or the like, or a pharmacologically acceptable salt thereof.

  本发明提供了一种具有肝糖原磷酸化酶抑制活性的吡唑化合物，用作糖尿病的治疗或预防剂，所述吡唑化合物由以下通用式（I）表示：其中环Q代表芳基或杂芳基，R1代表氢原子、卤原子、C1-6烷基或C1-6烷氧基，R2代表卤原子、C1-6烷基、C1-6烷氧基或偶氮基，R3代表卤原子、羟基、C1-6烷基、卤代C1-6烷基、C1-6烷氧基、偶氮基、氨基、酰胺基或C1-6烷基磺酰胺基，R4和R5彼此相同或不同，代表氢原子、取代或未取代的C1-6烷基、取代或未取代的C3-8环烷基、取代或未取代的饱和杂环基、取代或未取代的芳基、C7-14芳基烷基、杂芳基等，或其药理学上可接受的盐。
• COLORED CURABLE COMPOSITIONS, COLOR FILTERS AND PROCESS FOR PRODUCTION THEREOF
  申请人：FUJIFILM Corporation

  公开号：EP1780598A1

  公开（公告）日：2007-05-02

  The present invention provides a compound represented by the following Formula (C1), or a colored curable composition containing a tetraazaporphyrin colorant having at least one group represented by the following Formula (I), and a color filter using the composition and a manufacturing method thereof: wherein Rc1: a halogen atom, aliphatic group, aryl group, heterocyclic group, cyano group, carboxyl group, carbamoyl group, aliphatic oxycarbonyl group, aryloxycarbonyl group, acyl group, hydroxyl group, aliphatic oxy group, aryloxy group, etc.; Zc1: a non-metal atom group necessary for forming a 6-membered ring together with the carbon atom; M: two hydrogen atoms, a divalent metal atom, divalent metal oxide, divalent metal hydroxide, divalent metal chloride; cm= 0 to 2, cn= 0, 1 to 5; cr1, cr2, cr3, cr4= 0 to 1 (cr1 + cr2 + cr3 + cr4 ≥ 1); L1: an alkylene group; A1 and A2: -O-, -C(=O)-, -OC(=O)-, -C(=O)O-, -N(R2)C(=O)-, -C(=O)N(R2)-, -N(R2)C(=O)-, -OC(=O)N(R2)-, N(R2)C(=O)N(R3)-, -N(R2)SO2-, -SO2N(R2)-, or -SO2-; L2: an alkylene group, aralkylene group, or arylene group; n: an integer from 1 to 3; m: an integer from 0 to 3; R1: a hydrogen atom, alkyl group, aryl group or heterocyclic group; and R2 and R3: a hydrogen atom, alkyl group, aryl group or heterocyclic group.

  本发明提供了由下式（C1）表示的化合物，或含有至少一个基团由下式（I）表示的四氮杂卟啉着色剂的可着色固化组合物，以及使用该组合物的彩色滤光片及其制造方法： 其中 Rc1：卤素原子、脂肪族基团、芳基、杂环基团、氰基、羧基、氨基甲酰基、脂肪族氧基羰基、芳氧基羰基、酰基、羟基、脂肪族氧基、芳氧基等。M：两个氢原子、二价金属原子、二价金属氧化物、二价金属氢氧化物、二价金属氯化物；cm= 0 至 2，cn= 0、1 至 5；cr1、cr2、cr3、cr4= 0 至 1（cr1 + cr2 + cr3 + cr4 ≥ 1）；L1：亚烷基；A1 和 A2：-O-，-C(=O)-，-OC(=O)-，-C(=O)O-，-N(R2)C(=O)-，-C(=O)N(R2)-，-N(R2)C(=O)-，-OC(=O)N(R2)-，N(R2)C(=O)N(R3)-，-N(R2)SO2-，-SO2N(R2)-，或-SO2-； L2：亚烷基、芳烷基或芳基； n：R1：氢原子、烷基、芳基或杂环基团；R2 和 R3：氢原子、烷基、芳基或杂环基团。
• PYRAZOLE COMPOUND AND THERAPEUTIC AGENT FOR DIABETES COMPRISING THE SAME
  申请人：Japan Tobacco, Inc.

  公开号：EP1884513A1

  公开（公告）日：2008-02-06

  The present invention provides a pyrazole compound that has liver glycogen phosphorylase inhibitory activity and is useful as a therapeutic or prophylactic agent for diabetes, the pyrazole compound represented by the following general formula (I): wherein Ring Q represents an aryl or heteroaromatic group, R1 represents a hydrogen atom, a halogen atom, a C1-6 alkyl group or a C1-6 alkoxy group, R2 represents a halogen atom, a C1-6 alkyl group, a C1-6 alkoxy group or an azido group, R3 represents a halogen atom, a hydroxyl group, a C1-6 alkyl group, a halo C1-6 alkyl group, a C1-6 alkoxy group, an azido group, an amino group, an acylamino group or a C1-6 alkylsulfonylamino group, R4 and R5 are identical with or different from each other and represent a hydrogen atom, a substituted or unsubstituted C1-6 alkyl group, a C3-8 cycloalkyl group, a substituted or unsubstituted saturated heterocyclic group, a substituted or unsubstituted aryl group, a C7-14 aralkyl group, a heteroaromatic group, or the like, or a pharmacologically acceptable salt thereof.

  本发明提供了一种具有肝糖原磷酸化酶抑制活性并可用作糖尿病治疗或预防剂的吡唑化合物，该吡唑化合物由以下通式(I)表示： 其中环 Q 代表芳基或杂芳基，R1 代表氢原子、卤素原子、C1-6 烷基或 C1-6 烷氧基，R2 代表卤素原子、C1-6 烷基、C1-6 烷氧基或叠氮基，R3 代表卤素原子、羟基、C1-6 烷基、卤代 C1-6 烷基、C1-6 烷氧基、叠氮基、氨基、酰氨基或酰胺基、R4 和 R5 彼此相同或不同，代表氢原子、取代或未取代的 C1-6 烷基、C3-8 环烷基、取代或未取代的饱和杂环基、取代或未取代的芳基、C7-14 芳基、杂芳基或类似基团，或其药理学上可接受的盐。
• Optical material having a colored optically anisotropic layer
  申请人：Fujifilm Corporation

  公开号：EP2113807A2

  公开（公告）日：2009-11-04

  An optical material including a colored optically anisotropic layer, the colored optically anisotropic layer having at least one maximum absorption wavelength with a nonpolarized light transmittance of 30 percent or lower in a wavelength range of 430 to 700 nm, wherein the absorbance Amax at the polarization of maximum absorbance and the absorbance Amin at the polarization of minimum absorbance of the colored optically anisotropic layer satisfy the following relation at the maximum absorption wavelength: 1.0 ≤ Amax/Amin ≤ 1.4,and the in-plane retardation of the colored optically anisotropic layer is greater than or equal to 10 nm and less than 1,000 nm, which can be employed as a material for forming a color filter having optical compensation capability.

  一种光学材料，包括有色光学各向异性层，该有色光学各向异性层在430至700纳米的波长范围内具有至少一个最大吸收波长，其非偏振光透射率为30%或更低，其中有色光学各向异性层在最大吸收波长处的偏振吸光度Amax和在最小吸光度处的偏振吸光度Amin满足以下关系式：1.0 ≤ Amax/Amin ≤ 1.4，且有色各向异性光学层的面内延迟大于或等于 10 nm 且小于 1 000 nm，可用作形成具有光学补偿能力的彩色滤光片的材料。
• Colored curable composition, color filter and manufacturing method thereof
  申请人：Fujifilm Corporation

  公开号：EP2629149A2

  公开（公告）日：2013-08-21

  The present invention provides a colored curable composition comprising at least one compound represented by the following Formula (III) and a color filter using the composition and a manufacturing method thereof: wherein, in formula (III), L1 represents an alkylene group; A1 and A2 each independently represent -O-, -C(=O)-, -OC(=O)-, -C(=O)O-, -C(=O)N(R2)-, -N(R2)C(=O)-, -OC(=O)N(R2)-, -N(R2)C(=O)N(R3)-, -N(R2)SO2-, -SO2N(R2)-, or -SO2-; L2 represents an alkylene group, an aralkylene group, or an arylene group; n denotes an integer from 1 to 3; m denotes an integer from 0 to 3; when n is 2 or greater, L1s may be the same or different and A1s may be the same or different; when m is 2 or greater, L2s may be the same or different and A2s may be the same or different; R1 represents a hydrogen atom, an alkyl group, an aryl group or a heterocyclic group; R2 and R3 each independently represent a hydrogen atom, an alkyl group, an aryl group, or a heterocyclic group; and M represents a metal-containing substance.

  本发明提供了一种包含至少一种由下式（III）代表的化合物的彩色可固化组合物，以及使用该组合物的彩色滤光片及其制造方法： 其中，在式(III)中，L1代表亚烷基；A1和A2各自独立地代表-O-、-C(＝O)-、-OC(＝O)-、-C(＝O)O-、-C(＝O)N(R2)-、-N(R2)C(＝O)-、-OC(＝O)N(R2)-、-N(R2)C(＝O)N(R3)-、-N(R2)SO2-、-SO2N(R2)-或-SO2-；L2 代表亚烷基、芳烷基或芳基； n 表示 1 至 3 的整数； m 表示 0 至 3 的整数；当 n 为 2 或更大时，L1s 可以相同或不同，A1s 可以相同或不同；当 m 为 2 或更大时，L2s 可以相同或不同，A2s 可以相同或不同；R1 代表氢原子、烷基、芳基或杂环基团；R2 和 R3 各自独立地代表氢原子、烷基、芳基或杂环基团；以及 M 代表含金属物质。