benzyl(ethyl)(hydroxymethyl)phosphine | 1121894-17-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: benzyl(ethyl)(hydroxymethyl)phosphine
• CAS: 1121894-17-4
• 化学式: C₁₀H₁₅OP
• 分子量: 182.202
• InChiKey: HSBAVAPNEPAEGK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.64
• 重原子数：
  12.0
• 可旋转键数：
  4.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  20.23
• 氢给体数：
  1.0
• 氢受体数：
  1.0

反应信息

• 作为产物：
  描述：

  聚合甲醛 、 Ethylbenzylphosphin 以 水 为溶剂， 反应 1.0h， 以42%的产率得到benzyl(ethyl)(hydroxymethyl)phosphine
  参考文献：
  名称：

  Investigations into the Oxidative Stability of Hydroxymethyl- and Bis(Hydroxymethyl)-Phosphines

  摘要：

  Polydentate ligands containing the bis(hydroxymethyl)phosphine unit have been reported to exhibit enhanced oxidative stability, which would make them attractive for use in Tc-99m-radiopharmaceutical imaging agents. Benzylethyl(hydroxymethyl)phosphine, benzylbis(hydroxymethyl)phosphine and benzyldiethylphosphine were prepared in order to investigate the origin of this oxidative stability. Little evidence was found to indicate that the hydroxymethylphosphines show an enhanced level of stability, but it was demonstrated that the reaction conditions employed in their preparation generated a number of closely related by-products, which are likely to limit the usefulness of the hydroxymethylphosphines in commercial radiopharmaceutical applications.

  DOI：

  10.1080/10426500701761417