difluoromethylcyclopentadecane | 1126749-02-7

• 分子结构分类: 有机化合物 - 有机卤素化合物 - 有机氟化物
• 英文名称: difluoromethylcyclopentadecane
• 英文别名: Difluoromethylcyclopentadecane
• CAS: 1126749-02-7
• 化学式: C₁₆H₃₀F₂
• 分子量: 260.411
• InChiKey: UNCRKCXGQHEPPV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.3
• 重原子数：
  18
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  2-cyclopentadecyl-1,3-dithiane 在 三氟化溴 作用下， 以 一氟三氯甲烷 为溶剂， 以75%的产率得到difluoromethylcyclopentadecane
  参考文献：
  名称：

  Replacing the carbonyl's oxygen with the difluoromethyl group

  摘要：

  Aldehydes or ketones were reacted with 2-(trimethylsilyl)-1,3-dithiane (1) and the products reduced to the corresponding dithianes using tetrafluoroboric acid and sodium borohydride. These sulfur containing Compounds were reacted with bromine trifluoride under mild conditions (1-2 min, 0 C) with a net result of replacing the carbonyls' oxygen with the desired difluoromethyl moiety. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2008.12.042

文献信息

• Replacing the carbonyl's oxygen with the difluoromethyl group
  作者：Or Cohen、Youlia Hagooly、Shlomo Rozen

  DOI：10.1016/j.tet.2008.12.042

  日期：2009.2

  Aldehydes or ketones were reacted with 2-(trimethylsilyl)-1,3-dithiane (1) and the products reduced to the corresponding dithianes using tetrafluoroboric acid and sodium borohydride. These sulfur containing Compounds were reacted with bromine trifluoride under mild conditions (1-2 min, 0 C) with a net result of replacing the carbonyls' oxygen with the desired difluoromethyl moiety. (C) 2008 Elsevier Ltd. All rights reserved.