3-amino-1-(3-(benzylsulfonyl)phenyl)propan-1-ol | 1215075-95-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-amino-1-(3-(benzylsulfonyl)phenyl)propan-1-ol
• 英文别名: 3-Amino-1-(3-benzylsulfonylphenyl)propan-1-ol
• CAS: 1215075-95-8
• 化学式: C₁₆H₁₉NO₃S
• 分子量: 305.398
• InChiKey: OYFDVEJNLOUDFP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  21
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  88.8
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• SULPHUR-LINKED COMPOUNDS FOR TREATING OPHTHALMIC DISEASES AND DISORDERS
  申请人：Scott Ian L.

  公开号：US20100093865A1

  公开（公告）日：2010-04-15

  Provided are sulphur-linked compounds, pharmaceutical compositions thereof, and methods of treating ophthalmic diseases and disorders, such as age-related macular degeneration and Stargardt's Disease, using said compounds and compositions.

  提供的是硫连接化合物、其药物组合物以及使用所述化合物和组合物治疗眼科疾病和障碍的方法，例如年龄相关的黄斑变性和斯达加特病。
• Sealing gasket for closure and process for production of closure using the same
  申请人：TOYO SEIKAN KAISHA LIMITED

  公开号：EP1199324A1

  公开（公告）日：2002-04-24

  A sealing gasket for closure, made of a polyurethane elastomer obtained by reacting the following (A) and (B): (A) a polyisocyanate component having an isocyanate group content of 5 to 38% by weight and average 2 to 3 functional groups, obtained by modifying an aliphatic isocyanate and/or an alicyclic isocyanate, and (B) a polyol component having a hydroxyl value of 20 to 350 mgKOH/g and average 2 to 3 functional groups; and a process for producing a closure using such a sealing gasket. The closure sealing gasket made of a polyurethane elastomer, obtained by the present invention, when used for a closure (e.g. a metal closure of food container), resists yellowing by ultraviolet light, has a strength at least equal to those of sealing gaskets produced from an aromatic isocyanate and, moreover, excellent rubber properties, is low in dissolution in liquid foods contained in the food container, and promises sufficient sealability. The process for producing a closure according to the present invention is high in productivity and can use the production facilities for other materials such as polyvinyl chloride resin and the like.

  一种用于封闭的密封垫片，由聚氨酯弹性体制成，聚氨酯弹性体是由以下(A)和(B)反应而成： (A) 通过改性脂肪族异氰酸酯和/或脂环族异氰酸酯而获得的多异氰酸酯组 分，其异氰酸酯基含量为 5 至 38%（重量百分比），平均具有 2 至 3 个官能团，以及 (B) 具有 20 至 350 mgKOH/g 的羟值和平均 2 至 3 个官能团的多元醇组分；以及使用这种密封垫片生产封口的工艺。 本发明获得的由聚氨酯弹性体制成的封口密封垫片在用于封口（例如食品容器的金属封口）时，可防止紫外线照射变黄，其强度至少等于由芳香族异氰酸酯制成的密封垫片的强度，而且具有优异的橡胶性能，在食品容器所含液体食品中的溶解度低，并保证足够的密封性。 根据本发明生产密封垫的工艺生产率高，可以使用其他材料（如聚氯乙烯树脂等）的生产设备。
• SEALING MATERIAL FOR CAP AND PROCESS FOR PRODUCING CAP USING THE SAME
  申请人：TOYO SEIKAN KAISHA, LTD.

  公开号：EP1726605A1

  公开（公告）日：2006-11-29

  A sealing gasket for closure, made of a polyurethane elastomer obtained by reacting the following (A), (B) and (C) : (A) a polyisocyanate component having an isocyanate group content of 5 to 38% by weight and average 2 to 3 functional groups, obtained by modifying an aliphatic isocyanate and/or an alicyclic isocyanate, (B) a polyol component having a hydroxyl value of 20 to 350 mgKOH/g and average 2 to 3 functional groups, and (C) a glycerin fatty acid ester having hydroxyl group(s) ; and a process for producing a closure using such a sealing gasket. The closure sealing gasket made of a polyurethane elastomer, obtained by the present invention, when used for a closure (e.g. a metal closure of a food container having good sealing properties), is little eluted, is less in swelling with an alcoholic beverage and less in the absorption of the odor of the alcoholic beverage into the closure sealing gasket, and is tough, and causes no yellowing.

  一种封闭用密封垫片，由以下(A)、(B)和(C)反应得到的聚氨酯弹性体制成： (A) 通过改性脂肪族异氰酸酯和/或脂环族异氰酸酯而获得的多异氰酸酯组 分，其异氰酸酯基含量为 5%至 38%（重量百分比），平均具有 2 至 3 个官能团、 (B) 羟值为 20 至 350 mgKOH/g、平均具有 2 至 3 个官能团的多元醇组分，和 (C) 具有羟基的甘油脂肪酸酯； 以及一种使用这种密封垫片生产闭合件的工艺。 本发明获得的由聚氨酯弹性体制成的封口密封垫片在用于封口（例如具有良好密封性能的食品容器的金属封口）时，几乎不会被洗脱，较少与酒精饮料发生膨胀，较少将酒精饮料的气味吸收到封口密封垫片中，并且具有韧性，不会导致变黄。
• SULFUR-LINKED COMPOUNDS FOR TREATING OPTHALMIC DISEASES AND DISORDERS
  申请人：Acucela, Inc.

  公开号：EP2344451A2

  公开（公告）日：2011-07-20
• US6872796B2
  申请人：——

  公开号：US6872796B2

  公开（公告）日：2005-03-29