7-Bromo-2-chloro-3-thiophen-2-ylpyrido[2,3-b]pyrazine | 1000974-30-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶吡嗪类
• 英文名称: 7-Bromo-2-chloro-3-thiophen-2-ylpyrido[2,3-b]pyrazine
• 英文别名: 7-bromo-2-chloro-3-thiophen-2-ylpyrido[2,3-b]pyrazine
• CAS: 1000974-30-0
• 化学式: C₁₁H₅BrClN₃S
• 分子量: 326.604
• InChiKey: IJYRIYOKHDVVKL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  17
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  66.9
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  7-Bromo-2-chloro-3-thiophen-2-ylpyrido[2,3-b]pyrazine 、 1-甲基-1H-吡唑-4-硼酸 在 palladium bis[bis(diphenylphosphino)ferrocene] dichloride potassium carbonate 作用下， 以 1,4-二氧六环 、 水 为溶剂， 生成 C₁₅H₁₀BrN₅S
  参考文献：
  名称：

  Synthesis of unsymmetrical and regio-defined 2,3,6-quinoxaline and 2,3,7-pyridopyrazine derivatives

  摘要：

  Differential reactivity of the amine functionality in a number of common 1,2-diamine starting materials is exploited to undertake an expedient synthesis of unsymmetrical 2,3,6-trisubstituted quinoxaline and unsymmetrical 2,3,7-trisubstituted pyridopyrazine derivatives. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2007.10.117
• 作为产物：
  描述：

  7-bromo-3-thiophen-2-yl-1H-pyrido[2,3-b]pyrazin-2-one 在 三氯氧磷 作用下， 以30%的产率得到7-Bromo-2-chloro-3-thiophen-2-ylpyrido[2,3-b]pyrazine
  参考文献：
  名称：

  Synthesis of unsymmetrical and regio-defined 2,3,6-quinoxaline and 2,3,7-pyridopyrazine derivatives

  摘要：

  Differential reactivity of the amine functionality in a number of common 1,2-diamine starting materials is exploited to undertake an expedient synthesis of unsymmetrical 2,3,6-trisubstituted quinoxaline and unsymmetrical 2,3,7-trisubstituted pyridopyrazine derivatives. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2007.10.117

文献信息

• Synthesis of unsymmetrical and regio-defined 2,3,6-quinoxaline and 2,3,7-pyridopyrazine derivatives
  作者：Dan Sherman、Joel Kawakami、Hai-Ying He、Farah Dhun、Raphael Rios、Hu Liu、Weitao Pan、Yong-Jiang Xu、Sang-phyo Hong、Melissa Arbour、Marc Labelle、Matthew A.J. Duncton

  DOI：10.1016/j.tetlet.2007.10.117

  日期：2007.12

  Differential reactivity of the amine functionality in a number of common 1,2-diamine starting materials is exploited to undertake an expedient synthesis of unsymmetrical 2,3,6-trisubstituted quinoxaline and unsymmetrical 2,3,7-trisubstituted pyridopyrazine derivatives. (c) 2007 Elsevier Ltd. All rights reserved.