5-(4-methoxybenzyloxy)-2-((naphthalen-1-yloxy)methyl)-4H-pyran-4-one | 1443302-17-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 5-(4-methoxybenzyloxy)-2-((naphthalen-1-yloxy)methyl)-4H-pyran-4-one
• CAS: 1443302-17-7
• 化学式: C₂₄H₂₀O₅
• 分子量: 388.42
• InChiKey: RVHLGLOEEZQWFG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.96
• 重原子数：
  29.0
• 可旋转键数：
  7.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  57.9
• 氢给体数：
  0.0
• 氢受体数：
  5.0

反应信息

• 作为反应物：
  描述：

  5-(4-methoxybenzyloxy)-2-((naphthalen-1-yloxy)methyl)-4H-pyran-4-one 在 三氟乙酸 作用下， 以 二氯甲烷 为溶剂， 反应 0.5h， 以51%的产率得到5-hydroxy-2-((naphthalen-1-yloxy)methyl)-4H-pyran-4-one
  参考文献：
  名称：

  Synthesis of kojic acid derivatives as secondary binding site probes of d-amino acid oxidase

  摘要：

  A series of kojic acid (5-hydroxy-2-hydroxymethyl-4H-pyran-4-one) derivatives were synthesized and tested for their ability to inhibit D-amino acid oxidase (DAAO). Various substituents were incorporated into kojic acid at its 2-hydroxymethyl group. These analogs serve as useful molecular probes to explore the secondary binding site, which can be exploited in designing more potent DAAO inhibitors. (c) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2013.04.062
• 作为产物：
  描述：

  5-(4-甲氧基苄氧基)-2-(羟基甲基)-4H-吡喃-4-酮 在 2,6-二甲基吡啶 、 四溴化碳 、 sodium hydride 、 三苯基膦 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 反应 48.5h， 生成 5-(4-methoxybenzyloxy)-2-((naphthalen-1-yloxy)methyl)-4H-pyran-4-one
  参考文献：
  名称：

  Synthesis of kojic acid derivatives as secondary binding site probes of d-amino acid oxidase

  摘要：

  A series of kojic acid (5-hydroxy-2-hydroxymethyl-4H-pyran-4-one) derivatives were synthesized and tested for their ability to inhibit D-amino acid oxidase (DAAO). Various substituents were incorporated into kojic acid at its 2-hydroxymethyl group. These analogs serve as useful molecular probes to explore the secondary binding site, which can be exploited in designing more potent DAAO inhibitors. (c) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2013.04.062