(3R,9S,10R,13R,14R,17R)-4,4-Difluoro-17-((R)-5-methoxymethoxy-1,5-dimethyl-hexyl)-10,13-dimethyl-2,3,4,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol | 222535-33-3

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: (3R,9S,10R,13R,14R,17R)-4,4-Difluoro-17-((R)-5-methoxymethoxy-1,5-dimethyl-hexyl)-10,13-dimethyl-2,3,4,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol
• CAS: 222535-33-3
• 化学式: C₂₉H₄₆F₂O₃
• 分子量: 480.679
• InChiKey: RFFXUBVNRBYAOJ-LEPIVYPNSA-N

反应信息

• 作为反应物：
  描述：

  (3R,9S,10R,13R,14R,17R)-4,4-Difluoro-17-((R)-5-methoxymethoxy-1,5-dimethyl-hexyl)-10,13-dimethyl-2,3,4,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol 在 platinum(IV) oxide 氢气 作用下， 生成 (3R,9R,10R,13R,14R,17R)-4,4-Difluoro-17-((R)-5-methoxymethoxy-1,5-dimethyl-hexyl)-10,13-dimethyl-2,3,4,5,6,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-ol
  参考文献：
  名称：

  4,4-Difluoro-1α,25-dihydroxyvitamin D3: Analog to probe A-ring conformation in vitamin D-receptor complex

  摘要：

  4,4-Difluoro-1 alpha,25-dihydroxyvitamin D-3 was synthesized from ergosterol and analysis of its F-19 NMR showed it to be a useful probe to analyze the receptor-bound A-ring conformation of vitamin D. (C) 1999 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(99)00030-1
• 作为产物：
  描述：

  (9S,10R,13R,14R,17R)-17-((R)-5-Methoxymethoxy-1,5-dimethyl-hexyl)-10,13-dimethyl-1,2,6,9,10,11,12,13,14,15,16,17-dodecahydro-cyclopenta[a]phenanthren-3-one 在 sodium tetrahydroborate 、 potassium tert-butylate 、 N-氟代双苯磺酰胺 作用下， 生成 (3R,9S,10R,13R,14R,17R)-4,4-Difluoro-17-((R)-5-methoxymethoxy-1,5-dimethyl-hexyl)-10,13-dimethyl-2,3,4,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol 、 (3S,9S,10R,13R,14R,17R)-4,4-Difluoro-17-((R)-5-methoxymethoxy-1,5-dimethyl-hexyl)-10,13-dimethyl-2,3,4,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol
  参考文献：
  名称：

  4,4-Difluoro-1α,25-dihydroxyvitamin D3: Analog to probe A-ring conformation in vitamin D-receptor complex

  摘要：

  4,4-Difluoro-1 alpha,25-dihydroxyvitamin D-3 was synthesized from ergosterol and analysis of its F-19 NMR showed it to be a useful probe to analyze the receptor-bound A-ring conformation of vitamin D. (C) 1999 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(99)00030-1