3-fluoro-N-(5-(4-methyl-1-(thiazol-2-yl)-1,2,5,6-tetrahydropyridin-3-yl)pyrazin-2-yl)isonicotinamide | 1028699-07-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-fluoro-N-(5-(4-methyl-1-(thiazol-2-yl)-1,2,5,6-tetrahydropyridin-3-yl)pyrazin-2-yl)isonicotinamide
• 英文别名: 3-fluoro-N-[5-[4-methyl-1-(1,3-thiazol-2-yl)-3,6-dihydro-2H-pyridin-5-yl]pyrazin-2-yl]pyridine-4-carboxamide
• CAS: 1028699-07-1
• 化学式: C₁₉H₁₇FN₆OS
• 分子量: 396.448
• InChiKey: VVMMVDDGCODCIL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  28
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  112
• 氢给体数：
  1
• 氢受体数：
  8

文献信息

• COMPOUNDS FOR INFLAMMATION AND IMMUNE-RELATED USES
  申请人：Bohnert Gary

  公开号：US20100125080A1

  公开（公告）日：2010-05-20

  The invention relates to certain compounds, or pharmaceutically acceptable salts, solvates, clathrates, or prodrugs thereof, that are useful as immunosuppressive agents and for treating and preventing inflammatory conditions, allergic disorders, and immune disorders.

  本发明涉及某些化合物，或其药学上可接受的盐、溶剂合物、包合物或前药，它们可用作免疫抑制剂，并用于治疗和预防炎症状况、过敏性疾病和免疫性疾病。
• SUBSTITUTED PYRAZINAMIDE COMPOUNDS FOR INFLAMMATION AND IMMUNE-RELATED USES
  申请人：Synta Pharmaceuticals Corp.

  公开号：US20130303542A1

  公开（公告）日：2013-11-14

  The invention relates to certain compounds, or pharmaceutically acceptable salts, solvates, clathrates, or prodrugs thereof, that are useful as immunosuppressive agents and for treating and preventing inflammatory conditions, allergic disorders, and immune disorders.

  本发明涉及某些化合物，或其药学上可接受的盐，溶剂合物，笼合物或前药，其作为免疫抑制剂和治疗和预防炎症状况，过敏性疾病和免疫疾病有用。
• CYCLOHEXENYL-ARYL COMPOUNDS FOR INFLAMMATION AND IMMUNE-RELATED USES
  申请人：Synta Pharmaceuticals Corp.

  公开号：EP2086326B1

  公开（公告）日：2014-01-08
• [EN] CYCLOHEXENYL-ARYL COMPOUNDS FOR INFLAMMATION AND IMMUNE-RELATED USES<br/>[FR] COMPOSÉS CYCLOHEXÉNYL-ARYLE UTILISÉS DANS LE CADRE D'UNE INFLAMMATION OU DE TROUBLES IMMUNITAIRES
  申请人：SYNTA PHARMACEUTICALS CORP

  公开号：WO2008063504A2

  公开（公告）日：2008-05-29

  [EN] The invention relates to compounds of structural formula (I): or a pharmaceutically acceptable salt, solvate, clathrate, or prodrug thereof, wherein A, L, Y, W₁, W₂, Z, X, X₂, and n are defined herein. These compounds are useful as immunosuppressive agents and for treating and preventing inflammatory conditions, allergic disorders, and immune disorders.
  [FR] La présente invention concerne des composés de formule structurale (I), dans laquelle A, L, Y, W₁, W₂, Z, X, X₂ et n sont tels que définis dans cette invention, ou un sel, solvate, clathrate ou promédicament de ceux-ci, acceptables d'un point de vue pharmaceutique. Ces composés sont utilisés comme immunosuppresseurs et pour traiter et prévenir des états inflammatoires, des troubles allergiques et des troubles immunitaires.