17-hydroxy-21,24-dinor-17βH-chol-4-en-20-yn-3-one | 122798-65-6

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: 17-hydroxy-21,24-dinor-17βH-chol-4-en-20-yn-3-one
• 英文别名: 17-Hydroxy-21,24-dinor-17βH-chol-4-en-20-in-3-on；17α-propynyltestosterone；17α-Propinyl-androsten-(4)-ol-(17β)-on-(3)；17α-Propinyl-testosteron；21-Methyl-ethisteron；(8R,9S,10R,13S,14S,17S)-17-hydroxy-10,13-dimethyl-17-prop-1-ynyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-3-one
• CAS: 122798-65-6
• 化学式: C₂₂H₃₀O₂
• 分子量: 326.479
• InChiKey: QPECSSJUOHOWIC-GUCLMQHLSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  24
• 可旋转键数：
  1
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.77
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  17-hydroxy-21,24-dinor-17βH-chol-4-en-20-yn-3-one 在 吡啶 、 对甲苯磺酸 作用下， 以 1,4-二氧六环 为溶剂， 生成 3-Ethoxy-17β-propionyloxy-17α-propin-1-yl-testadien-3,5
  参考文献：
  名称：

  修饰的类固醇激素-XXXIII：甾体6-甲酰基-3-烷氧基-3、5-二烯及其一些转化

  摘要：

  甾族3-烷氧基-3，5-二烯与Vilsmeier试剂之间的反应导致相应的6-甲酰基衍生物的高产率。这些中间体被还原成3-烷氧基-6-羟甲基-3，5-二烯，其经酸脱水成6-亚甲基-4-en-3-one。

  DOI：

  10.1016/s0040-4020(01)98622-3
• 作为产物：
  描述：

  17α-Propin-(1')-yl-androsten-(5)-diol-(3β,17β) 在 环己酮 、 aluminum isopropoxide 、 甲苯 作用下， 生成 17-hydroxy-21,24-dinor-17βH-chol-4-en-20-yn-3-one
  参考文献：
  名称：

  Barton et al., Journal of the Chemical Society, 1959, p. 1957,1959

  摘要：

  DOI：

文献信息

• Esters of hyaluronic acid and their salts.
  申请人：FIDIA S.p.A.

  公开号：EP0216453A2

  公开（公告）日：1987-04-01

  The invention concerns the esters of hyaluronic acid in which all or only a portion of the carboxylic groups of the acid are esterified, and the salts of the partial esters with metals or with pharmacologically acceptable organic bases. The compounds possess interesting and precious bio- plastic and pharmaceutical properties and may be used in innumerable fields, including cosmetics, surgery and medicine. The invention also includes pharmaceutical preparations containing, as an active ingredient, one or more hyaluronic acid esters, or a salt thereof as described above, as well as medicaments containing: 1) a pharmacologically active substance or an association of pharmacologically active substances and 2) a carrying vehicle containing a total or partial ester of hyaluronic acid. The invention includes also various uses of the hyaluronic esters or of the above mentioned medicaments, such as in medicine, surgery or cosmetics. The invention also relates to a new procedure for the preparation of polysaccharide esters containing carboxylic groups, such as in particular the above mentioned hayluronic acid esters.

  本发明涉及全部或仅部分羧基被酯化的透明质酸酯，以及部分酯与金属或药理学上可接受的有机碱的盐。 这些化合物具有有趣而珍贵的生物塑料和药物特性，可用于无数领域，包括化妆品、外科手术和医药。本发明还包括含有一种或多种透明质酸酯或其上述盐类作为活性成分的药物制剂，以及含有以下成分的药品： 1) 一种药理活性物质或药理活性物质的组合，以及 2) 含有全部或部分透明质酸酯的载体。 本发明还包括透明质酸酯或上述药剂的各种用途，如医药、外科手术或化妆品。 本发明还涉及一种制备含有羧基的多糖酯的新工艺，特别是上述海藻糖酸酯。
• Crosslinked carboxy polysaccharides
  申请人：FIDIA S.p.A.

  公开号：EP0341745A1

  公开（公告）日：1989-11-15

  Inter and/or intramolecular cross-linked esters of acid polysaccharides are disclosed in which a part or all of the carboxy groups are esterified with hydroxyl groups of the same molecule and/or of different molecules of the acid polysaccharide. These inner cross-linked esters of polysaccharide acids are useful in the field of biodegradable plastic materials, to manufacture sanitary and surgical articles, in the cosmetic and pharmaceutical fields, in the food industry and in many other industrial fields.

  本发明公开了酸性多糖的分子间和/或分子内交联酯，其中部分或全部羧基与酸性多糖同一分子和/或不同分子的羟基酯化。这些内交联多糖酸酯可用于生物可降解塑料材料领域、卫生和外科用品制造领域、化妆品和医药领域、食品工业和许多其他工业领域。
• Gellan esters
  申请人：FIDIA S.p.A.

  公开号：EP0518710A1

  公开（公告）日：1992-12-16

  In the total and partial esters of gellan, the esterifying alcohol component is derived from aliphatic, araliphatic, cycloaliphatic or heterocyclic alcohols ; and salts of said partial esters are obtained with inorganic or organic bases. A pharmaceutical preparation contains, as an active ingredient, an effective amount of a gellan ester or one of its salts as defined, or one of its salts together with a pharmaceutically acceptable excipient. The total or partial ester of gellan or a salt thereof is used in ophthalmology, dermatology, otolaryngology, dentistry, angiology, obstetrics or neurology.

  在结冷胶总酯和部分酯中，酯化醇成分来自脂肪族、脂肪族、环脂肪族或杂环醇；所述部分酯的盐可通过无机或有机碱获得。 药物制剂含有有效量的结冷酯或其盐类，或其盐类与药学上可接受的赋形剂一起作为活性成分。 结冷胶总酯或部分酯或其盐可用于眼科、皮肤科、耳鼻喉科、牙科、血管科、产科或神经科。
• Compositions comprising partial esters of alginic acid
  申请人：FIDIA S.p.A.

  公开号：EP0609968A2

  公开（公告）日：1994-08-10

  The invention relates to compositions comprising partial esters of alginic acid as well as their use in the surgery, sanitary and cosmetic fields.

  本发明涉及由部分海藻酸酯组成的组合物及其在外科、卫生和美容领域的用途。
• Partial esters of acidic polysaccharides
  申请人：FIDIA S.p.A.

  公开号：EP0615979A2

  公开（公告）日：1994-09-21

  New polysaccharide esters are disclosed, and more precisely partial esters of acidic polysaccharides chosen from the group formed by carboxymethylcellulose, carboxymethyl starch and carboxymethylchitin. These new esters and some esters of the type already known are useful as medicaments, for the manufacture of pharmaceutical and cosmetic preparations, in the field of biodegradable plastic materials and, therefore, for the manufacture of medical, surgical and sanitary articles, as well as numerous other industrial sectors in the place of acidic polysaccharides now in common use.

  本发明公开了新的多糖酯，更确切地说，是从羧甲基纤维素、羧甲基淀粉和羧甲基几丁质组成的组中选出的酸性多糖的部分酯。这些新的酯类和一些已知的酯类可用作药物，用于制造医药和化妆品制剂，也可用于生物可降解塑料材料领域，因此可用于制造医疗、外科和卫生用品，还可用于许多其他工业部门，取代目前常用的酸性多糖。