4-[4-furan-3-yl-2,5-bis-(2-trifluoromethyl-phenoxymethyl)-phenyl]-1,2,3,6-tetrahydro-pyridine hydrochloride salt | 474330-29-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-[4-furan-3-yl-2,5-bis-(2-trifluoromethyl-phenoxymethyl)-phenyl]-1,2,3,6-tetrahydro-pyridine hydrochloride salt
• 英文别名: 4-[4-(Furan-3-yl)-2,5-bis[[2-(trifluoromethyl)phenoxy]methyl]phenyl]-1,2,3,6-tetrahydropyridine;hydrochloride
• CAS: 474330-29-5
• 化学式: C₃₁H₂₅F₆NO₃*ClH
• 分子量: 609.996
• InChiKey: CBATUCFXIKYFNH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.94
• 重原子数：
  42
• 可旋转键数：
  8
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  43.6
• 氢给体数：
  2
• 氢受体数：
  10

文献信息

• Inhibitors of bace
  申请人：——

  公开号：US20030095958A1

  公开（公告）日：2003-05-22

  The present invention relates to inhibitors of aspartic proteinases, particularly, BACE. The present invention also relates to compositions thereof and methods therewith for inhibiting BACE activity in a mammal, and for treating Alzheimer's Disease and other BACE-mediated diseases.

  本发明涉及天冬氨酸蛋白酶抑制剂，特别是BACE。本发明还涉及其组合物和方法，用于在哺乳动物中抑制BACE活性，并用于治疗阿尔茨海默病和其他BACE介导的疾病。
• INHIBITORS OF BACE
  申请人：VERTEX PHARMACEUTICALS INCORPORATED

  公开号：EP1389194A2

  公开（公告）日：2004-02-18
• COMPOUNDS AND USES THEREOF FOR DECREASING ACTIVITY OF HORMONE-SENSITIVE LIPASE
  申请人：NOVO NORDISK A/S

  公开号：EP1458374A2

  公开（公告）日：2004-09-22
• [EN] INHIBITORS OF BACE<br/>[FR] INHIBITEURS DE BACE
  申请人：VERTEX PHARMA

  公开号：WO2002088101A2

  公开（公告）日：2002-11-07

  The present invention relates to inhibitors of aspartic proteinases, particularly, BACE. The present invention also relates to compositions thereof and methods therewith for inhibiting BACE activity in a mammal, and for treating Alzheimer's Disease and other BACE-mediated diseases.
• [EN] COMPOUNDS AND USES THEREOF FOR DECREASING ACTIVITY OF HORMONE-SENSITIVE LIPASE<br/>[FR] COMPOSES RALENTISSANT L'ACTIVITE DE LA LIPASE HORMONO-SENSIBLE
  申请人：NOVO NORDISK AS

  公开号：WO2003051841A2

  公开（公告）日：2003-06-26

  Carbamates and related compounds of formula R1 R2NCO-Y or R1 R2NCS-Y wherein R1 and R2 are hydrogen, alkyl, aryl, heteroaryl or may together form a piperidine, piperazine, morpholine or other heterocyclic ring, are inhibitors of hormone sensitive lipase and are useful for the treatment of any disorder where it is desirable to modulate the plasma level of free fatty acids, glycerol, LDL-cholesterol, HDL-cholesterol, insulin and/or glucose; and or modulate intracellular triacylglycerol and cholesterol stores, intracellular level of fatty acids, fatty acid esters such as diacylglycerols, phosphatidic acids, long chain acyl-CoA's as well as citrate or malonyl-CoA; and or increase insulin sensitivity ; and or modulate insulin secretion from pancreatic beta cells. More particularly said disorders are selected from the group consisting of insulin resistance, diabetes type 1, diabetes type 2, metabolic syndrome X, impaired glucose tolerance, hyperclycemia, dislipidemia, obesity, abnormalities of lipoprotein metabolism and any combinations. thereof.