Trifluoro-methanesulfonic acid 8-benzyloxy-naphthalen-2-yl ester | 350584-54-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: Trifluoro-methanesulfonic acid 8-benzyloxy-naphthalen-2-yl ester
• 英文别名: (8-Phenylmethoxynaphthalen-2-yl) trifluoromethanesulfonate；(8-phenylmethoxynaphthalen-2-yl) trifluoromethanesulfonate
• CAS: 350584-54-2
• 化学式: C₁₈H₁₃F₃O₄S
• 分子量: 382.36
• InChiKey: VAUSRNQRRAOJOP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.4
• 重原子数：
  26
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  61
• 氢给体数：
  0
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  Trifluoro-methanesulfonic acid 8-benzyloxy-naphthalen-2-yl ester 在 palladium on activated charcoal 、 三乙胺 bis-triphenylphosphine-palladium(II) chloride 、 copper(l) iodide 、 氢气 、 四丁基碘化铵 作用下， 以 甲醇 、 N,N-二甲基甲酰胺 为溶剂， 生成
  参考文献：
  名称：

  Convergent synthesis of potent peptide inhibitors of the Grb2-SH2 domain by palladium catalyzed coupling of a terminal alkyne

  摘要：

  A new strategy was developed to prepare in a very efficient and convergent manner C-terminal modified tripeptides with high affinities for the Grb2-SH2 domain. Using Pd(PPh3)(2)Cl-2 as catalyst, selected naphthyl iodides and triflates were coupled to Ac-Pmp(t-Bu)(2)-Ac(6)c-Asn-NH(prop-2-ynyl). The resulting alkyne derivatives were hydrogenated and deprotected to afford potent Grb2-SH2 inhibitors. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(01)00173-1
• 作为产物：
  描述：

  1,7-二羟基萘 在 吡啶 、 caesium carbonate 作用下， 以 1,4-二氧六环 为溶剂， 生成 Trifluoro-methanesulfonic acid 8-benzyloxy-naphthalen-2-yl ester
  参考文献：
  名称：

  Convergent synthesis of potent peptide inhibitors of the Grb2-SH2 domain by palladium catalyzed coupling of a terminal alkyne

  摘要：

  A new strategy was developed to prepare in a very efficient and convergent manner C-terminal modified tripeptides with high affinities for the Grb2-SH2 domain. Using Pd(PPh3)(2)Cl-2 as catalyst, selected naphthyl iodides and triflates were coupled to Ac-Pmp(t-Bu)(2)-Ac(6)c-Asn-NH(prop-2-ynyl). The resulting alkyne derivatives were hydrogenated and deprotected to afford potent Grb2-SH2 inhibitors. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(01)00173-1

文献信息

• Convergent synthesis of potent peptide inhibitors of the Grb2-SH2 domain by palladium catalyzed coupling of a terminal alkyne
  作者：Joseph Schoepfer、Brigitte Gay、Nicole End、Evelyne Muller、Gisela Scheffel、Giorgio Caravatti、Pascal Furet

  DOI：10.1016/s0960-894x(01)00173-1

  日期：2001.5

  A new strategy was developed to prepare in a very efficient and convergent manner C-terminal modified tripeptides with high affinities for the Grb2-SH2 domain. Using Pd(PPh3)(2)Cl-2 as catalyst, selected naphthyl iodides and triflates were coupled to Ac-Pmp(t-Bu)(2)-Ac(6)c-Asn-NH(prop-2-ynyl). The resulting alkyne derivatives were hydrogenated and deprotected to afford potent Grb2-SH2 inhibitors. (C) 2001 Elsevier Science Ltd. All rights reserved.