6-[5-(Azepan-1-ylamino)-4-cyano-3-trifluoromethyl-pyrazol-1-yl]-pyridine-3-sulfonic acid amide | 519008-16-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 6-[5-(Azepan-1-ylamino)-4-cyano-3-trifluoromethyl-pyrazol-1-yl]-pyridine-3-sulfonic acid amide
• 英文别名: 6-[5-(Azepan-1-ylamino)-4-cyano-3-(trifluoromethyl)pyrazol-1-yl]pyridine-3-sulfonamide
• CAS: 519008-16-3
• 化学式: C₁₆H₁₈F₃N₇O₂S
• 分子量: 429.426
• InChiKey: MFZROPXVEBNACB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  29
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  138
• 氢给体数：
  2
• 氢受体数：
  11

文献信息

• Hydrazinyl and nitrogen oxide pyrazoles
  申请人：Pfizer Inc.

  公开号：US20030134850A1

  公开（公告）日：2003-07-17

  The present invention relates to hydrazinyl and nitrogen oxide pyrazoles of the formula I: 1 wherein the ring of the formula (R 5 )-A-(SO m R 4 ), m, X, R 1 through R 5 are as defined in the specification, to pharmaceutical compositions containing them and to their medicinal use. The compounds of the invention are useful in the treatment or alleviation of inflammation and other inflammation associated disorders, such as arthritis, colon cancer and Alzheimer's disease in mammals, preferably humans, dogs, cats and livestock animals.

  本发明涉及式I的肼基和氮氧化物吡唑：1其中，式（R5）-A-（SOmR4），m，X，R1至R5的环如规范中所定义，以及包含它们的制药组合物和它们的医药用途。本发明的化合物在哺乳动物中，尤其是人类、狗、猫和家畜动物中，用于治疗或缓解炎症和其他与炎症相关的疾病，如关节炎、结肠癌和阿尔茨海默病。
• Method for producing tryptamine derivatives
  申请人：——

  公开号：US20030096379A1

  公开（公告）日：2003-05-22

  The invention relates to a coupled enzymatic process for producing tryptamine derivatives from indole compounds. In the first enzyme-catalyzed reaction, indole derivatives are converted to tryptophan derivative intermediates, then the tryptophan intermediates are decarboxylated in a second enzymatic reaction in the same reaction system. In this way, tryptamine derivative products are formed from indole derivatives in a single process. The invention is also directed to novel tryptophan and tryptamine derivatives, which can be prepared by the inventive method.

  本发明涉及一种从吲哚化合物中生产色胺衍生物的耦合酶促反应过程。在第一次酶催化反应中，吲哚衍生物被转化为色氨酸衍生物中间体，然后在同一反应体系中进行第二次酶催化反应，将色氨酸中间体脱羧。这样，通过单一过程从吲哚衍生物中形成色胺衍生物产品。该发明还涉及新型色氨酸和色胺衍生物，可以通过本发明方法制备。
• Pour point depressant treated fatty acid esters as biodegradable, combustion engine fuels
  申请人：THE LUBRIZOL CORPORATION

  公开号：EP0626442A1

  公开（公告）日：1994-11-30

  A composition is described that comprises (A) esters from the transesterification of at least one animal fat or vegetable oil triglyceride of the formula with an alcohol R⁴OH wherein R¹, R² and R³ are aliphatic groups containing from about 6 to about 24 carbon atoms and R⁴ is an aliphatic group containing from 1 to about 10 carbon atoms; and (B) a pour point depressant. In addition to components (A) and (B), the composition may also contain an additive (C) and/or (D) a normally liquid fuel.

  所述组合物包括 (A) 由至少一种动物脂肪或植物油甘油三酯与下列式子的醇 R⁴OH 进行酯交换反应生成的酯类 其中 R¹、R² 和 R³ 是含有约 6 至约 24 个碳原子的脂肪族基团，R⁴ 是含有 1 至约 10 个碳原子的脂肪族基团；以及 (B) 一种降凝剂。 除了成分 (A) 和 (B)，组合物还可包含添加剂 (C) 和/或 (D) 通常液体燃料。
• Compositions containing triglycerides and transesterified triglycerides
  申请人：THE LUBRIZOL CORPORATION

  公开号：EP0651044A2

  公开（公告）日：1995-05-03

  This invention relates to a composition containing the combination of: (A) at least one vegetable or synthetic triglyceride, (B) esters from the transesterification of at least one animal or vegetable oil triglyceride, (C) a pour point depressant, and (D) a performance additive. The composition may optionally contain    (E) other oils.

  本发明涉及一种含有以下成分组合的组合物： (A) 至少一种植物或合成甘油三酯、 (B) 至少一种动物油或植物油甘油三酯的酯类、 (C) 一种降凝剂，以及 (D) 一种高性能添加剂。 组合物可选择含有 (E) 其他油类。
• Esters derived from vegetable oils used as additives for fuels
  申请人：THE LUBRIZOL CORPORATION

  公开号：EP0860494A1

  公开（公告）日：1998-08-26

  A fuel composition is disclosed which comprises (A) at least one low sulfur diesel fuel; and (B) esters from the transesterification of at least one vegetable oil triglyceride of the formula wherein R1, R2 and R3 are aliphatic hydrocarbyl groups having at least 60 percent monounsaturated character and containing from about 6 to about 24 carbon atoms with an alcohol R4OH wherein R4 is an aliphatic group containing from 1 to about 24 carbon atoms.

  公开了一种燃料组合物，它包括 (A) 至少一种低硫柴油；和 (B) 由至少一种植物油甘油三酯酯化而成的酯，其式如下 其中 R1、R2 和 R3 是脂肪族烃基，具有至少 60%的单不饱和性质，并含有约 6 至约 24 个碳原子；R4 是醇 R4OH，其中 R4 是脂肪族基团，含有 1 至约 24 个碳原子。