2-chloro-3-fluoro-N-(2-(2-methylpyrimidin-5-yl)-2-(pyridin-4-yl)ethyl)benzamide | 1600495-82-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-chloro-3-fluoro-N-(2-(2-methylpyrimidin-5-yl)-2-(pyridin-4-yl)ethyl)benzamide
• 英文别名: 2-chloro-3-fluoro-N-[2-(2-methylpyrimidin-5-yl)-2-pyridin-4-ylethyl]benzamide
• CAS: 1600495-82-6
• 化学式: C₁₉H₁₆ClFN₄O
• 分子量: 370.814
• InChiKey: HZECEGAQKXABBD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  26
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.16
• 拓扑面积：
  67.8
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  2-氯-3-氟苯甲酸 、 2-(2-Methylpyrimidin-5-yl)-2-(pyridin-4-yl)ethanamine 生成 2-chloro-3-fluoro-N-(2-(2-methylpyrimidin-5-yl)-2-(pyridin-4-yl)ethyl)benzamide
  参考文献：
  名称：

  Benzamides

  摘要：

  本发明涉及含苯酰胺化合物，其抑制P2X7受体。

  公开号：

  US09102591B2

文献信息

• [EN] AZAINDOLINES<br/>[FR] AZAINDOLINES
  申请人：HOFFMANN LA ROCHE

  公开号：WO2014056867A1

  公开（公告）日：2014-04-17

  Disclosed are compounds of Formula (I) or pharmaceutically acceptable salts thereof, wherein W, Y, Z, R1, R2, R3 and R4 are as described in this application, and methods of using the compounds in the treatment of cancer.

  揭示了式（I）的化合物或其药用盐，其中W、Y、Z、R1、R2、R3和R4如本申请所述，并且使用这些化合物治疗癌症的方法。
• Benzamides-containing compounds and their use in the treatment of epilepsy
  申请人：MINDIMMUNE THERAPEUTICS, INC.

  公开号：US10238654B2

  公开（公告）日：2019-03-26

  The present invention is directed to benzamide-containing compounds of formula I or pharmaceutically acceptable salts thereof which inhibit the P2X7 receptor, and their use in the treatment of epilepsy.

  本发明涉及式 I 的含苯甲酰胺化合物 或其药学上可接受的盐，它们能抑制 P2X7 受体，并可用于治疗癫痫。
• BENZAMIDES
  申请人：H. Lundbeck A/S

  公开号：EP2906546A1

  公开（公告）日：2015-08-19
• Benzamides-Containing Compounds and Their Use in the Treatment of Epilepsy
  申请人：H. Lundbeck A/S

  公开号：US20170202836A1

  公开（公告）日：2017-07-20

  The present invention is directed to benzamide-containing compounds of formula I or pharmaceutically acceptable salts thereof which inhibit the P2X 7 receptor, and their use in the treatment of epilepsy.
• BENZAMIDES-CONTAINING COMPOUNDS AND THEIR USE IN THE TREATMENT OF DEPRESSION
  申请人：MINDIMMUNE THERAPEUTICS, INC.

  公开号：US20200054630A1

  公开（公告）日：2020-02-20

  The present invention is directed to benzamide-containing compounds of formula I or pharmaceutically acceptable salts thereof which inhibit the P2X 7 receptor, and their use in the treatment of depression.