{2-[(7-hydroxy-benzofuran-2-carbonyl)-amino]phenyl}-carbamic acid tert-butyl ester | 738596-43-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: {2-[(7-hydroxy-benzofuran-2-carbonyl)-amino]phenyl}-carbamic acid tert-butyl ester
• 英文别名: tert-butyl N-[2-[(7-hydroxy-1-benzofuran-2-carbonyl)amino]phenyl]carbamate
• CAS: 738596-43-5
• 化学式: C₂₀H₂₀N₂O₅
• 分子量: 368.389
• InChiKey: LUNMFXDZCDMDRY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  27
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  101
• 氢给体数：
  3
• 氢受体数：
  5

文献信息

• N-monoacylated o-phenylenediamines
  申请人：——

  公开号：US20040157841A1

  公开（公告）日：2004-08-12

  Mono-acylated o-phenylendiamines derivatives of formula I 1 wherein X and R are as described herein, have been found useful for the treatment of diseases mediated by the inhibition of histone deacetylase, such as cancer.

  其中X和R如本文所述，具有以下结构的I1式单酰化的邻苯二胺衍生物，已被发现对通过抑制组蛋白去乙酰化酶介导的疾病，如癌症的治疗有用。
• N-MONOACYLATED O-PHENYLENEDIAMINES AS ANTI-CANCER AGENTS
  申请人：F. HOFFMANN-LA ROCHE AG

  公开号：EP1594857A2

  公开（公告）日：2005-11-16
• US7208491B2
  申请人：——

  公开号：US7208491B2

  公开（公告）日：2007-04-24
• [EN] NOVEL N-MONOACYLATED O-PHENYLENEDIAMINES, THEIR CONDENSED HETEROCYCLIC DERIVATIVES AND THEIR USE AS PHARMACEUTICAL AGENTS<br/>[FR] NOUVELLES O-PHENYLENEDIAMINES N-MONOACYLEES ET LEURS DERIVES HETEROCYCLIQUES CONDENSES, ET UTILISATION DE CEUX-CI COMME AGENTS PHARMACEUTIQUES
  申请人：HOFFMANN LA ROCHE

  公开号：WO2004069133A2

  公开（公告）日：2004-08-19

  Objects of the present invention are new mono-acylated o-phenylendiamines derivatives of formula (I), wherein X represents N, S or O; R represents CH3-(O-CH2CH2)n- or C1-C6-alkyl, which alkyl group is monosubstituted with -CO2H, -OH, R1R2N-, pyridin-2-yl, pyrrolidin-1-yl, piperidino or morpholino; R1, R2 independently from each other denote C1-C6 alkyl; n is 1, 2, 3 or 4; and pharmaceutically acceptable salts thereof. The present invention also encompasses pharmaceutically acceptable salts or prodrugs of the compounds of formula I as well as the use of these compounds to produce medicaments.