Diphenhydramine maleate | 114402-66-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Diphenhydramine maleate
• 英文别名: 2-benzhydryloxy-N,N-dimethylethanamine;(Z)-but-2-enedioic acid
• CAS: 114402-66-3
• 化学式: C21H25NO5
• 分子量: 371.4
• InChiKey: HTOPDYMCGZYYAS-BTJKTKAUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.07
• 重原子数：
  27
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  87.1
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• Hot melt method for preparing diphenhydramine tannate
  申请人：Jame Fine Chemicals, Inc.

  公开号：US20040198667A1

  公开（公告）日：2004-10-07

  The invention pertains to a method for preparing diphenhydramine tannate by reacting diphenhydramine free base at a temperature of about 75 to about 150° C. with tannic acid neat or as an aqueous slurry containing up to about 20 wt. % water. The diphenhydramine free base may be obtained by reacting a commercially available diphenhydranine salt such as diphenhydramine maleate with a base such as aqueous sodium hydroxide. The resultant diphenhydramine tannate has extended release properties and is useful in pharmaceutical compositions as an antihistamine for human beings.

  本发明涉及一种制备苯海拉明丹纳酸盐的方法，包括在约75至150℃的温度下，将苯海拉明自由碱与单质的丹宁酸或含有多达约20重量％水的水浆状丹宁酸反应。苯海拉明自由碱可通过将商业上可获得的苯海拉明盐（如苯海拉明马来酸盐）与碱（如水合氢氧化钠）反应而得到。所得的苯海拉明丹纳酸盐具有延长释放性能，并可用作人类抗组胺药物的制剂。
• COATED PARTICLE AND METHOD FOR PRODUCING COATED PARTICLE
  申请人：Kobe Gakuin Educational Foundation

  公开号：EP2570120A1

  公开（公告）日：2013-03-20

  The present invention relates to a coating particle containing a nuclear particle covered with a coating layer, and in the coating particle, the coating layer is a layer containing hydroxyalkyl cellulose and a binder.

  本发明涉及一种涂层颗粒，它含有被涂层层覆盖的核颗粒，在涂层颗粒中，涂层层是含有羟烷基纤维素和粘合剂的层。
• HYDROXYALKYL CELLULOSE
  申请人：Nippon Soda Co., Ltd.

  公开号：EP2647648A1

  公开（公告）日：2013-10-09

  The present invention provides a hydroxyalkyl cellulose having a viscosity of 1.10 mPa·s to 1.95 mPa·s in a 2%-concentration aqueous solution at 20°C, and a solid formulation containing the hydroxyalkyl cellulose.

  本发明提供了一种羟烷基纤维素，其在 20°C 浓度为 2% 的水溶液中的粘度为 1.10 mPa-s 至 1.95 mPa-s，还提供了一种含有羟烷基纤维素的固体制剂。
• Coated particle and method for producing coated particle
  申请人：Ichikawa Hideki

  公开号：US10888520B2

  公开（公告）日：2021-01-12

  The present invention relates to a coating particle containing a nuclear particle covered with a coating layer, and in the coating particle, the coating layer is a layer containing hydroxyalkyl cellulose and a binder.

  本发明涉及一种涂层颗粒，它含有被涂层层覆盖的核颗粒，在涂层颗粒中，涂层层是含有羟烷基纤维素和粘合剂的层。
• Film-forming agent for drug delivery and preparation for percutaneous administration containing the same
  申请人：——

  公开号：US20030199644A1

  公开（公告）日：2003-10-23

  The present invention relates to a film-forming agent which forms a film on the skin, and also to a preparation for percutaneous administration containing the film-forming agent and active ingredient. The transdermal preparation including the film-forming agent of the present invention and active ingredient exhibits excellent elasticity and flexibility, shows superior adhesion power when formed on the skin, and forms non-sticky film.

  本发明涉及一种可在皮肤上成膜的成膜剂，还涉及一种含有该成膜剂和活性成分的经皮给药制剂。包含本发明成膜剂和活性成分的透皮制剂具有良好的弹性和柔韧性，在皮肤上成膜时显示出卓越的附着力，并形成不粘的薄膜。