3,5-Dichloro-2-(1-chloroethyl)pyridine | 2048237-96-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 3,5-Dichloro-2-(1-chloroethyl)pyridine
• 英文别名: 3,5-dichloro-2-(1-chloroethyl)pyridine
• CAS: 2048237-96-1
• 化学式: C₇H₆Cl₃N
• 分子量: 210.5
• InChiKey: GPAJIHVBMRTFCJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  12.9
• 氢给体数：
  0
• 氢受体数：
  1

文献信息

• SUBSTITUTED BENZAMIDES AND METHODS OF USE THEREOF
  申请人：GENENTECH, INC.

  公开号：US20160340309A1

  公开（公告）日：2016-11-24

  The invention provides compounds having activity as sodium channel (e.g., NaV1.7) inhibitors that are useful for treating sodium channel-mediated diseases or conditions, such as pain, as well as other diseases and conditions associated with the mediation of sodium channels, and compositions containing such compounds and methods for using such compounds and compositions.

  这项发明提供了具有钠通道（例如NaV1.7）抑制剂活性的化合物，这些化合物对治疗由钠通道介导的疾病或症状（如疼痛）以及与钠通道介导相关的其他疾病和症状有用，以及含有这些化合物的组合物和使用这些化合物和组合物的方法。
• Substituted benzamides and methods of use thereof
  申请人：GENENTECH, INC.

  公开号：US10179767B2

  公开（公告）日：2019-01-15

  The invention provides compounds having activity as sodium channel (e.g., NaV1.7) inhibitors that are useful for treating sodium channel-mediated diseases or conditions, such as pain, as well as other diseases and conditions associated with the mediation of sodium channels, and compositions containing such compounds and methods for using such compounds and compositions.

  本发明提供了具有钠通道（如 NaV1.7）抑制剂活性的化合物，这些化合物可用于治疗钠通道介导的疾病或病症，如疼痛，以及与钠通道介导相关的其他疾病和病症，还提供了含有此类化合物的组合物以及使用此类化合物和组合物的方法。
• [EN] SUBSTITUTED BENZAMIDES AND METHODS OF USE THEREOF<br/>[FR] BENZAMIDES SUBSTITUÉS ET LEURS MÉTHODES D'UTILISATION
  申请人：GENENTECH INC

  公开号：WO2016191312A1

  公开（公告）日：2016-12-01

  The invention provides compounds having activity as sodium channel (e.g., NaV1.7) inhibitors that are useful for treating sodium channel-mediated diseases or conditions, such as pain, as well as other diseases and conditions associated with the mediation of sodium channels, and compositions containing such compounds and methods for using such compounds and compositions.