2-iodo-3-phenyl-1-propanol | 86151-66-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-iodo-3-phenyl-1-propanol
• 英文别名: 2-Iodo-3-phenylpropan-1-ol
• CAS: 86151-66-8
• 化学式: C₉H₁₁IO
• 分子量: 262.09
• InChiKey: MWFRVPIJSDRRDT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  11
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  烯丙苯 、 水 以28%的产率得到
  参考文献：
  名称：

  SATO, TADASHI;TAMURA, KUNIO;NAGAYAOSHI, KAZUO, CHEM. LETT., 1983, N 5, 791-794

  摘要：

  DOI：

文献信息

• A CONVENIENT SYNTHETIC METHOD OF 1,3-DISUBSTITUTED ISOQUINOLINES USING SILVER TRIFLUOROMETHANESULFONATE AS A KEY REAGENT
  作者：Tadashi Sato、Kunio Tamura、Kazuo Nagayoshi

  DOI：10.1246/cl.1983.791

  日期：1983.5.5

  1,3-Disubstituted isoquinolines were prepared under mild conditions from allylbenzenes and nitriles using silver trifluoromethanesulfonate and iodine.

  1,3-二取代异喹啉是在温和条件下，使用三氟甲磺酸银和碘从烯丙基苯和腈制备的。
• Electrochemical Synthesis of Iodohydrins
  作者：Shinan Luan、Thomas Castanheiro、Thomas Poisson

  DOI：10.1002/adsc.202200470

  日期：2022.8.16

  Iodohydrins and corresponding ethers were synthesized by an electrochemical process using inexpensive and non-toxic ammonium iodide. This transformation was applied to a panel of alkenes, giving products without the need of external hazardous oxidants, reductants or metal catalyst. This protocol showed a general efficiency to synthesize valuable iodinated molecules with yields from 19% to 90%.

  使用廉价且无毒的碘化铵通过电化学方法合成碘醇和相应的醚。这种转变应用于一组烯烃，无需外部有害氧化剂、还原剂或金属催化剂即可得到产品。该协议显示了合成有价值的碘化分子的一般效率，产率从 19% 到 90%。
• m-Iodosylbenzoic acid, a tagged hypervalent iodine reagent for the iodo-functionalization of alkenes and alkynes
  作者：Mekhman S. Yusubov、Roza Ya. Yusubova、Andreas Kirschning、Joo Yeon Park、Ki-Whan Chi

  DOI：10.1016/j.tetlet.2007.12.120

  日期：2008.2

  An efficient and facile method for the iodo-functionalization of alkenes 5 and alkynes 6 by using recyclable ni-iodosylbenzoic acid (2) was developed. The final products can be easily isolated without any chromatographic purification by simple treatment of the crude mixture with an anionic exchange resin. Unreacted m-iodosylbenzoic acid and reduced m-iodobenzoic acid are effectively recovered from the resin by acidification with hydrochloric acid. (c) 2008 Elsevier Ltd. All rights reserved.
• Iodomethane Oxidation by Dimethyldioxirane:  A New Route to Hypoiodous Acid and Iodohydrines
  作者：Gregorio Asensio、Cecilia Andreu、Carmen Boix-Bernardini、Rossella Mello、María Elena González-Nuñez

  DOI：10.1021/ol9903281

  日期：1999.12.1

  [GRAPHICS]The oxidation of iodomethane with dimethyldioxirane allows the generation of stable neutral solutions of hypoiodous acid in the absence of any trapping agent for iodide anion. Hypoiodous acid is trapped in situ by addition to representative olefins to give iodohydrines in good yields. The stereochemical study of the products shows the anti-stereospecific nature of the iodohydroxylation reaction.