2-imino-3-naphthalen-2-yl-5-[(3-nitrophenyl)methylidene]-1,3-thiazolidin-4-one | 1392572-97-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 2-imino-3-naphthalen-2-yl-5-[(3-nitrophenyl)methylidene]-1,3-thiazolidin-4-one
• CAS: 1392572-97-2
• 化学式: C₂₀H₁₃N₃O₃S
• 分子量: 375.408
• InChiKey: QOAYAFAEIYWRPC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  27.0
• 可旋转键数：
  3.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  87.3
• 氢给体数：
  1.0
• 氢受体数：
  5.0

反应信息

• 作为产物：
  描述：

  2-萘胺 在 sodium acetate 、 溶剂黄146 作用下， 以 丙酮 、 苯 为溶剂， 反应 8.0h， 生成 2-imino-3-naphthalen-2-yl-5-[(3-nitrophenyl)methylidene]-1,3-thiazolidin-4-one
  参考文献：
  名称：

  Synthesis of Novel 2-Iminothiazolidin-4-ones

  摘要：

  Thiazolidin-4-ones are known to exhibit diverse biological activities such as antimicrobial, anticancer, antidiarrheal, anticonvulsant, antidiabetic, antihistaminic, and antifungal activities. In the present investigation, a series of 2-haloacetamides was prepared by reacting chloroacetyl chloride with amines in dry benzene under reflux conditions. The formed 2-haloacetamides reacted with potassium thiocyanate in refluxing dry acetone to afford new 2-iminothiazolidin-4-ones. The 5-arylidene-2-imino-3 (napthalen-2yl)-thiazolidin-4-ones were prepared by condensing 2-iminothiazolidin-4-ones with substituted benzaldehydes. All the products were characterized by infrared, mass, and H-1 and C-13 NMR techniques.

  DOI：

  10.1080/00397911.2011.582217