ethyl 2-((1r,4r)-4-(4-(2-((3,4-dichlorophenyl)carbamoyl)imidazo[1,2-a]pyridin-6-yl)phenyl)cyclohexyl)acetate | 1449781-03-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: ethyl 2-((1r,4r)-4-(4-(2-((3,4-dichlorophenyl)carbamoyl)imidazo[1,2-a]pyridin-6-yl)phenyl)cyclohexyl)acetate
• CAS: 1449781-03-6
• 化学式: C₃₀H₂₉Cl₂N₃O₃
• 分子量: 550.485
• InChiKey: ZEFOBEWRPXBDMW-MXVIHJGJSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.79
• 重原子数：
  38.0
• 可旋转键数：
  7.0
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  72.7
• 氢给体数：
  1.0
• 氢受体数：
  5.0

文献信息

• [EN] COMPOUNDS AS INHIBITORS OF DIACYLGLYCEROL O-ACYLTRANSFERASE TYPE 1 ENZYME<br/>[FR] COMPOSÉS COMME INHIBITEURS DE L'ENZYME DIACYLGLYCÉROL O-ACYLTRANSFÉRASE DE TYPE 1
  申请人：KAINOS MEDICINE INC

  公开号：WO2013119040A1

  公开（公告）日：2013-08-15

  The invention provides a novel compound having activity against diacylglycerol O-acyltransferase type 1 (DGAT1); a pharmaceutical composition for preventing or treating a disease, disorder or condition modulated by inhibition of DGAT1 comprising said compound; a method for preventing or treating a disease, disorder or condition modulated by inhibition of DGAT1 in an individual comprising administering said compound to the individual in need thereof; and a use of said compound for the manufacture of a medicament for preventing or treating a disease, disorder or condition modulated by DGAT1 inhibition.

  本发明提供了一种对二酰甘油O-酰基转移酶1（DGAT1）具有活性的新化合物；一种用于预防或治疗通过抑制DGAT1调节的疾病，障碍或病症的制剂，包括该化合物；一种预防或治疗个体中通过抑制DGAT1调节的疾病，障碍或病症的方法，包括向需要该化合物的个体施用该化合物；以及用于制造预防或治疗通过DGAT1抑制调节的疾病，障碍或病症的药物的该化合物的用途。
• POLYMER INTERLAYERS COMPRISING UV ABSORBERS
  申请人：SOLUTIA INC.

  公开号：US20150158276A1

  公开（公告）日：2015-06-11

  A UV stable polymer composition comprising a poly(vinyl acetal) resin, a plasticizer and at least one UV absorber, wherein the ultraviolet absorber comprises structure (1)
• CHLOROPRENE RUBBER COMPOSITION AND ADHESIVE COMPOSITION USING SAID CHLOROPRENE RUBBER COMPOSITION
  申请人：DENKI KAGAKU KOGYO KABUSHIKI KAISHA

  公开号：US20160017130A1

  公开（公告）日：2016-01-21

  An object of the invention is to provide a chloroprene polymer composition resistant to discoloration under heat or light. Provided is a chloroprene rubber composition, prepared by carrying out emulsion polymerization in the presence of 0.5 to 7.0 parts by mass of a rosin acid salt as emulsifier and terminating the emulsion polymerization by addition of a polymerization inhibitor and a phosphorus- or phenol-based compound as antioxidant. It is possible according to the invention to obtain a chloroprene polymer composition superior in discoloration resistance under heat or light. The chloroprene polymer composition according to the present invention can be used favorably for adhesion of cloths, leathers, foamed sheets, papers, woods, shoe parts, and others.
• US9328228B2
  申请人：——

  公开号：US9328228B2

  公开（公告）日：2016-05-03