(2E)-2-[(2-nitrophenyl)methylidene]heptanal | 1433691-23-6

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 肉桂醛
• 英文名称: (2E)-2-[(2-nitrophenyl)methylidene]heptanal
• CAS: 1433691-23-6
• 化学式: C₁₄H₁₇NO₃
• 分子量: 247.294
• InChiKey: NNGPXYFVJUMLOY-ZRDIBKRKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  18
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  62.9
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  庚醛 、 邻硝基苯甲醛 在 四氢吡咯 作用下， 以 neat (no solvent) 为溶剂， 反应 0.25h， 以95%的产率得到(2E)-2-[(2-nitrophenyl)methylidene]heptanal
  参考文献：
  名称：

  Microwave-assisted organocatalytic cross-aldol condensation of aldehydes

  摘要：

  本研究介绍了一种在无溶剂微波辐照条件下进行醛类物质的交醛缩合的环境友好型有机催化方法。以吡咯烷为催化剂，开发了一种高效、可持续的原子经济方法，用于多种醛的交醛缩合，并取得了优异的结果。其中合成了茉莉醛、α-己基肉桂醛和仙客来醛这三种工业需求量很大的化合物。

  DOI：

  10.1039/c3ra00114h

文献信息

• COMPOUNDS, COMPOSITIONS AND METHODS OF USE FOR NICOTINE CESSATION AND CHEMOPREVENTION
  申请人：PACIFIC UNIVERSITY

  公开号：US20200129449A1

  公开（公告）日：2020-04-30

  Compounds, compositions, and methods of use of such compounds and compositions are provided for reducing human dependency to nicotine. In one example, a method of treating an individual with an addiction to nicotine comprises administering to the individual a compound that is a structural analog of trans-cinnamaldehyde. Based on the administration, a rate at which nicotine is metabolized may be reduced, which in turn may reduce a desire for the individual to consume nicotine-containing products.
• CINNAMALDEHYDE DERIVATIVE COMPOUNDS AND METHODS OF USE FOR CINNAMALDEHYDE DERIVATIVE COMPOUNDS NICOTINE CESSATION
  申请人：Pacific University.

  公开号：US20220142946A1

  公开（公告）日：2022-05-12

  Compounds, compositions, and methods of use of such compounds and compositions are provided for reducing human dependency to nicotine. In one example, a method of treating an individual with an addiction to nicotine comprises administering to the individual a compound that is a structural analog of trans-cinnamaldehyde. Based on the administration, a rate at which nicotine is metabolized may be reduced, which in turn may reduce a desire for the individual to consume nicotine-containing products.