4-Amino-1-benzoyl-5-fluoropyrimidin-2-one | 467249-27-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-Amino-1-benzoyl-5-fluoropyrimidin-2-one
• CAS: 467249-27-0
• 化学式: C₁₁H₈FN₃O₂
• 分子量: 233.202
• InChiKey: VWWQBNXNFAJOST-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  17
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  75.8
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• N1-acyl-5-fluoropyrimidinone derivatives
  申请人：Boebel Timothy A.

  公开号：US20110034490A1

  公开（公告）日：2011-02-10

  This present disclosure is related to the field of N1-acyl-5-fluoropyrimidinones and their derivatives and to the use of these compounds as fungicides.

  本公开涉及N1-酰基-5-氟嘧啶酮及其衍生物领域，以及将这些化合物用作杀真菌剂的用途。
• [EN] DIOXOLANE ANALOGUES OF URIDINE FOR THE TREATMENT OF CANCER<br/>[FR] ANALOGUES DIOXOLANE D'URIDINE POUR LE TRAITEMENT DU CANCER
  申请人：MEDIVIR AB

  公开号：WO2016030335A1

  公开（公告）日：2016-03-03

  The invention provides compounds of formula (I), wherein: R1 is OR11, or NR5R5'; R2 is H or F; R5 is H, C1-C6alkyl, OH, C(=O)R6, O(C=O)R6 or O(C=O)OR6; R5´ is H or C1-C6alkyl; R6 is C1-C6alkyl or C3-C7cycloalkyl; R13 is H, phenyl, pyridyl, benzyl, indolyl or naphthyl wherein the phenyl, pyridyl, benzyl, indolyl and naphthyl is optionally substituted with 1, 2 or 3 R22; and the other variables are as defined in the claims, which are of use in the treatment of cancer, and related aspects.

  这项发明提供了式(I)的化合物，其中：R1为OR11或NR5R5'；R2为H或F；R5为H、C1-C6烷基、OH、C(=O)R6、O(C=O)R6或O(C=O)OR6；R5´为H或C1-C6烷基；R6为C1-C6烷基或C3-C7环烷基；R13为H、苯基、吡啶基、苄基、吲哚基或萘基，其中苯基、吡啶基、苄基、吲哚基和萘基可选择地被1、2或3个R22取代；其他变量如索权中所定义，用于癌症治疗及相关方面。
• [EN] A PROCESS FOR CHIRAL RESOLUTION OF 2-SUBSTITUTED 4-SUBSTITUTED 1,3-OXATHIOLANES<br/>[FR] PROCÉDÉ POUR LA RÉSOLUTION CHIRALE DE 1,3-OXATHIOLANES SUBSTITUÉS EN 2, SUBSTITUÉS EN 4
  申请人：AVEXA LTD

  公开号：WO2009039582A1

  公开（公告）日：2009-04-02

  The present invention relates to a novel process for the chiral resolution of 2-substituted 4-substituted 1,3-oxathiolanes and derivatives thereof. The present invention also relates to novel 2-substituted 4-substituted 1,3-oxathiolanes derivatives.

  本发明涉及一种新颖的用于手性分离2-取代的4-取代的1,3-噁硫环己烷及其衍生物的方法。本发明还涉及新颖的2-取代的4-取代的1,3-噁硫环己烷衍生物。
• Method for synthesizing cyclic bisdinucleoside
  申请人：Hayakawa Yoshihiro

  公开号：US20060167241A1

  公开（公告）日：2006-07-27

  A compound represented by Formula [2]: wherein R 2 and R 3 each independently represent a hydrogen atom, a halogen atom, a methoxy group, a 2-methoxyethoxy group or a hydroxyl group; and B 2 and B 3 each independently represent a nucleic acid base, or a salt thereof can be synthesized from a compound represented by Formula [1]: wherein R 1 represents a hydrogen atom, a halogen atom, a methoxy group, a 2-methoxyethoxy group, or a hydroxyl group substituted with a hydroxyl protecting group; and B 1 represents a nucleic acid base which may be protected.

  化合物的化学式为[2]，其中R2和R3各自独立地表示氢原子、卤素原子、甲氧基、2-甲氧基乙氧基或羟基；B2和B3各自独立地表示核酸碱基或其盐。该化合物可以从化学式[1]表示的化合物合成，其中R1表示氢原子、卤素原子、甲氧基、2-甲氧基乙氧基或羟基，且带有羟基保护基；B1表示可能被保护的核酸碱基。
• PROCESS FOR CHIRAL RESOLUTION OF 2-SUBSTITUTED 4-SUBSTITUTED 1,3-OXATHIOLANES
  申请人：Epa Widanagamage Ruwansiri

  公开号：US20100305321A1

  公开（公告）日：2010-12-02

  The present invention relates to a novel process for the chiral resolution of 2-substituted 4-substituted 1,3-oxathiolanes and derivatives thereof. The present invention also relates to novel 2-substituted 4-substituted 1,3-oxathiolanes derivatives.

  本发明涉及一种新型的对2-取代的4-取代的1,3-氧噻烷及其衍生物进行手性分离的方法。本发明还涉及新型的2-取代的4-取代的1,3-氧噻烷衍生物。