Carbamic acid, (3-chloro-5-(1-((6-(2-(5-ethyl-4-methyl-2-thiazolyl)ethyl)-4-(4-morpholinyl)-2-pyridinyl)amino)ethyl)phenyl)-, 1-methylethyl ester | 329716-61-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Carbamic acid, (3-chloro-5-(1-((6-(2-(5-ethyl-4-methyl-2-thiazolyl)ethyl)-4-(4-morpholinyl)-2-pyridinyl)amino)ethyl)phenyl)-, 1-methylethyl ester
• 英文别名: propan-2-yl N-[3-chloro-5-[1-[[6-[2-(5-ethyl-4-methyl-1,3-thiazol-2-yl)ethyl]-4-morpholin-4-ylpyridin-2-yl]amino]ethyl]phenyl]carbamate
• CAS: 329716-61-2
• 化学式: C₂₉H₃₈ClN₅O₃S
• 分子量: 572.2
• InChiKey: AZGZXUZMWKHDDH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.4
• 重原子数：
  39
• 可旋转键数：
  11
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.48
• 拓扑面积：
  117
• 氢给体数：
  2
• 氢受体数：
  8

文献信息

• [EN] HETEROARYLTHIOMETHYL PYRIDINE DERIVATIVE<br/>[FR] DÉRIVÉ D'HÉTÉROARYLTHIOMÉTHYL PYRIDINE
  申请人：BANYU PHARMA CO LTD

  公开号：WO2010126163A1

  公开（公告）日：2010-11-04

  The present invention relates to a compound represented by a formula (I): wherein X is a group represented by or the like; Y is a group represented by or the like; and Ar1 is a group represented by or a pharmaceutically acceptable salt thereof.

  本发明涉及一种由以下公式（I）表示的化合物：其中X是由表示的基团或类似的基团；Y是由表示的基团或类似的基团；Ar1是由表示的基团或其药用可接受盐。
• NOVEL AZOLE DERIVATIVES
  申请人：BANYU PHARMACEUTICAL CO., LTD.

  公开号：EP1566384A1

  公开（公告）日：2005-08-24

  The present invention relates to a compound of the formula (I): wherein Az is a group comprising a monocyclic azole or a bicyclic aromatic ring of the same or different fused azoles; T, U, V and W are independently methine or nitrogen, said methine being optionally substituted by a substituent, and at least two of T, U, V and W are said methine groups; and X is nitrogen or methine. The compounds of the present invention are useful as agents for the treatment of various kinds of diseases related to NPY, for example, cardiovascular disorders, nervous system disorders, genitative diseases, metabolic diseases, genital or reproductive disorders, gastro-intestinal disorders, respiratory disorders, inflammatory diseases or glaucoma, and the like.

  本发明涉及一种式（I）化合物： 其中，Az 是由单环唑或相同或不同的融合唑的双环芳环组成的基团；T、U、V 和 W 独立地是甲烷或氮，所述甲烷可任选地被取代基取代，且 T、U、V 和 W 中至少有两个是所述甲烷基团；以及 X 是氮或甲烷。 本发明的化合物可用作治疗与 NPY 有关的各种疾病的药物，例如心血管疾病、神经系统疾病、遗传性疾病、代谢性疾病、生殖器或生殖系统疾病、胃肠道疾病、呼吸系统疾病、炎症性疾病或青光眼等。
• NOVEL BENZIMIDAZOLE DERIVATIVES
  申请人：BANYU PHARMACEUTICAL CO., LTD.

  公开号：EP1517908A2

  公开（公告）日：2005-03-30
• HETEROARYLTHIOMETHYL PYRIDINE DERIVATIVE
  申请人：MSD K.K.

  公开号：EP2424860A1

  公开（公告）日：2012-03-07
• [EN] NOVEL BENZIMIDAZOLE DERIVATIVES<br/>[FR] NOUVEAUX DÉRIVÉS DE BENZIMIDAZOLE
  申请人：BANYU PHARMA CO LTD

  公开号：WO2004002986A2

  公开（公告）日：2004-01-08

  A compound of the formula (I): (wherein A, B, C and D are independently nitrogen or optionally! I substituted methine; E is nitrogen, methine or hydroxyl, substituted methine; n is 0 or 1; T, U, V and W are independently!, nitrogen or optionally substituted methine; X is -N(SOZR4)-, N (COR5) - or -CO- ; Y is -C (R6) (R7) - , -O- or -N (RS) - provided that the compound (I) when E is nitrogen, n is 0, X is -CO-, and Y is -0 is excluded). is useful as an agent for the treatment of various diseases related to NPY neuropeptide Y.