1-acetyl-2,5-dimethyl-pyrrolidine | 228099-02-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: 1-acetyl-2,5-dimethyl-pyrrolidine
• 英文别名: 1-(2,5-Dimethylpyrrolidin-1-yl)ethanone
• CAS: 228099-02-3
• 化学式: C₈H₁₅NO
• 分子量: 141.213
• InChiKey: MMWXQPVKFGTXCE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  10
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  20.3
• 氢给体数：
  0
• 氢受体数：
  1

文献信息

• [EN] SUBSTITUTED CYCLOPROPYL COMPOUNDS USEFUL AS GPR119 AGONISTS<br/>[FR] COMPOSÉS DE CYCLOPROPYLE SUBSTITUÉS UTILES À TITRE D'AGONISTES DE GPR119
  申请人：MERCK SHARP & DOHME

  公开号：WO2013074388A1

  公开（公告）日：2013-05-23

  Substituted cyclopropyl compounds of the formula (I): and pharmaceutically acceptable salts thereof are disclosed as useful for treating or preventing type 2 diabetes and similar conditions. The compounds are useful as agonists of the G-protein coupled receptor GPR-119. Pharmaceutical compositions and methods of treatment are also included

  公开了公式（I）的环丙基化合物及其药学上可接受的盐，用于治疗或预防2型糖尿病和类似疾病。这些化合物可作为G蛋白偶联受体GPR-119的激动剂。还包括药物组合物和治疗方法。
• 2-HETEROARYL-SUBSTITUTED INDOLE DERIVATIVE
  申请人：Takahashi Keiji

  公开号：US20090118304A1

  公开（公告）日：2009-05-07

  Disclosed is a compound represented by the formula (I) below, which has a glucokinase-activating effect and is thus useful for treatment of diabetes or obesity, or a pharmaceutically acceptable salt thereof. In the formula, R 1 represents an aryl or the like; R 11 represents an aryl or the like; R 2 represents a formyl or the like, R 3 represents a C 1-6 alkyl or the like; R 3 represents a hydrogen atom or the like; Z 1 represents —O— or the like; Z 2 represents —O— or the like; Y 1 -Y 4 respectively represent a carbon atom or a nitrogen atom; ring A represents a heteroaryl group; X represents a carbon atom or the like; m represents an integer of 0-2; and q represents an integer of 0-2.

  本发明涉及一种化合物，其公式如下（I），具有激活葡萄糖激酶的作用，因此可用于治疗糖尿病或肥胖症，或其药学上可接受的盐。在公式中，R1代表芳基或类似物; R11代表芳基或类似物; R2代表甲酰基或类似物，R3代表C1-6烷基或类似物; R3代表氢原子或类似物; Z1代表—O—或类似物; Z2代表—O—或类似物; Y1-Y4分别代表碳原子或氮原子; 环A代表杂环芳基; X代表碳原子或类似物; m代表0-2的整数; q代表0-2的整数。
• AMINOALKYLPYRIMIDINE DERIVATIVES AS HISTAMINE H4 RECEPTOR ANTAGONISTS
  申请人：Carceller Gonzalez Elena

  公开号：US20130018031A1

  公开（公告）日：2013-01-17

  Aminoalkylpyrimidine derivatives of formula I, wherein the meaning of the different substituents are those indicated in the description. These compounds are useful as histamine H 4 receptor antagonists.

  公式I的氨基烷基嘧啶衍生物，其中不同取代基的含义如描述中所示。这些化合物可用作组胺H4受体拮抗剂。
• SUBSTITUTED CYCLOPROPYL COMPOUNDS USEFUL AS GPR119 AGONISTS
  申请人：Merck Sharp & Dohme Corp.

  公开号：US20140329798A1

  公开（公告）日：2014-11-06

  Substituted cyclopropyl compounds of the formula (I): and pharmaceutically acceptable salts thereof are disclosed as useful for treating or preventing type 2 diabetes and similar conditions. The compounds are useful as agonists of the G-protein coupled receptor GPR-119. Pharmaceutical compositions and methods of treatment are also included

  本发明公开了式（I）的取代环丙基化合物及其药学上可接受的盐，用于治疗或预防2型糖尿病和类似疾病。该化合物是G蛋白偶联受体GPR-119的激动剂，因此在药物组合物和治疗方法中也有用途。
• Catalyst and process for hydrogenating olefinically unsaturated compound
  申请人：JSR Corporation

  公开号：EP0974602B1

  公开（公告）日：2004-01-02