1-N,1-N,4-N-triphenyl-4-N-[4-[4-[4-(4-phenyl-N-[4-(N-phenylanilino)phenyl]anilino)phenyl]phenyl]phenyl]benzene-1,4-diamine | 1032984-83-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-N,1-N,4-N-triphenyl-4-N-[4-[4-[4-(4-phenyl-N-[4-(N-phenylanilino)phenyl]anilino)phenyl]phenyl]phenyl]benzene-1,4-diamine
• CAS: 1032984-83-0
• 化学式: C₇₂H₅₄N₄
• 分子量: 975.248
• InChiKey: OACZPWVYKGIRFV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  19.8
• 重原子数：
  76
• 可旋转键数：
  15
• 环数：
  12.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  13
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  1-N,1-N,4-N-triphenyl-4-N-[4-[4-[4-(4-phenyl-N-[4-(N-phenylanilino)phenyl]anilino)phenyl]phenyl]phenyl]benzene-1,4-diamine 、 3-[hydroxy-(3-phenylbutyl)phosphinoyl]propionic acid 在 N,N-二异丙基乙胺 、 Methanaminium,N-[(dimethylamino)(3H-1,2,3-triazolo[4,5-b]pyridin-3-yloxy)methylene]-N-methyl-, hexafluorophosphate(1-) 、 三氟乙酸 作用下， 以 N-甲基吡咯烷酮 、 二氯甲烷 、 水 为溶剂， 反应 3.0h， 生成 2(S)-[2(S)-{3-[hydroxy-(3-phenylbutyl)phosphinoyl]propionyl}amino-3-methylbutyrylamino]hexanoic acid
  参考文献：
  名称：

  Selective inhibitors of neurotensin degrading enzymes

  摘要：

  本发明的实施例涉及选择性神经肽降解酶抑制剂化合物，含有这些化合物的药物组合物，制备这些化合物的方法，用于合成这些化合物的新型中间体的制备方法，以及制备含有这些化合物的组合物的方法。该发明还涉及利用这些化合物和组合物来调节血压或胃排空，或用于治疗帕金森病、焦虑、抑郁或精神病的用途。这些化合物的化学式如下（1），其中符号的含义如规范中所述。

  公开号：

  US20080146524A1

文献信息

• AROMATIC AMINE DERIVATIVE AND ORGANIC ELECTROLUMINESCENCE DEVICE USING THE SAME
  申请人：YABUNOUCHI Nobuhiro

  公开号：US20080145707A1

  公开（公告）日：2008-06-19

  The present invention provides a novel aromatic amine derivative enabling to obtain an organic electroluminescence device which is driven under a low voltage, exhibits small increase in the driving voltage after continuous driving for a long time and has a long life. The amine derivative is represented by the following general formula (1). In the formula, R 1 to R 7 each represent, for example, hydrogen atom or a substituted or unsubstituted aryl group having 5 to 50 nuclear carbon atoms; a represents an integer of 1 or greater; b, c, g and h each represent an integer of 1 to 5, and d, e and f each represent an integer of 1 to 4; and Ar 1 and Ar 2 represent a group represented by following general formulae (2) and (3), respectively, and the groups represented by Ar 1 and Ar 2 are not same with each other. R 8 to R 11 each represent, for example, hydrogen atom; and i and m each represent an integer of 1 to 5, j and k each represent an integer of 1 to 4, n and p each represent an integer of 0 or greater, and n≠p.

  本发明提供了一种新的芳香胺衍生物，使得可以获得一种在低电压下驱动的有机电致发光器件，其在连续驱动长时间后驱动电压的增加很小，并且具有长寿命。该胺衍生物由以下通式（1）表示。在该式中，R1至R7分别表示氢原子或具有5到50个核碳原子的取代或未取代芳基基团；a表示大于或等于1的整数；b、c、g和h分别表示1到5的整数，d、e和f分别表示1到4的整数；Ar1和Ar2分别表示由以下通式（2）和（3）表示的基团，且由Ar1和Ar2表示的基团不相同。R8至R11分别表示氢原子；i和m分别表示1到5的整数，j和k分别表示1到4的整数，n和p分别表示大于或等于0的整数，且n≠p。
• Aza-Residue Modulation of Cyclic <scp>d</scp>,<scp>l</scp>-α-Peptide Nanotube Assembly with Enhanced Anti-Amyloidogenic Activity
  作者：Maram Habashi、Pradeep S. Chauhan、Suresh Vutla、Sudipta Senapati、Mykhailo Diachkov、Ali EL-Husseini、Brigitte Guérin、William D. Lubell、Shai Rahimipour

  DOI：10.1021/acs.jmedchem.2c02049

  日期：2023.2.23

  Transient soluble oligomers of amyloid-β (Aβ) are considered among the most toxic species in Alzheimer’s disease (AD). Soluble Aβ oligomers accumulate early prior to insoluble plaque formation and cognitive impairment. The cyclic d,l-α-peptide CP-2 (1) self-assembles into nanotubes and demonstrates promising anti-amyloidogenic activity likely by a mechanism involving engagement of soluble oligomers. Systematic

  淀粉样蛋白-β (Aβ) 的瞬时可溶性低聚物被认为是阿尔茨海默病 (AD) 中毒性最强的物种之一。可溶性 Aβ 寡聚体在不溶性斑块形成和认知障碍之前早期积累。环状d , l -α-肽 CP-2 ( 1 ) 自组装成纳米管并显示出有前途的抗淀粉样蛋白生成活性，这可能是通过涉及可溶性低聚物参与的机制实现的。肽1中残基的系统置换与氮杂氨基酸对应物进行了探索氢键对减轻 Aβ 聚集和毒性的倾向的影响。某些氮杂肽表现出提高的参与、改变二级结构和抑制 Aβ 聚集的能力。此外，某些氮杂肽可分解预先形成的 Aβ 原纤维并保护细胞免受 Aβ 介导的毒性。用氮杂正亮氨酸和氮杂高丝氨酸分别取代肽1中的l -正亮氨酸3和d -丝氨酸6残基，提供无毒的 [azaNle 3 ]- 1 ( 4 ) 和 [azaHse 6 ]- 1 ( 7), 通过降低 Aβ 寡聚体水平显着减轻转基因秀丽隐杆线虫AD 模型的症状。
• ORGANIC ELECTROLUMINESCENCE DEVICE
  申请人：Jinde Yukitoshi

  公开号：US20100301312A1

  公开（公告）日：2010-12-02

  An organic electroluminescence device including: an anode ( 10 ), a cathode ( 70 ), an emitting layer ( 40 ) including an organic compound, which is between the anode ( 10 ) and the cathode ( 70 ), two or more layers arranged in a hole injection and transport region which is between the anode ( 10 ) and the emitting layer ( 40 ), and one or more layers arranged in an electron injection and transport region which is between the emitting layer ( 40 ) and the cathode ( 70 ), wherein a layer in the hole injection and transport region, which is in contact with the emitting layer ( 40 ), includes an aromatic amine derivative having a carbazole skeleton, one of the layers other than the layer in contact with the emitting layer ( 40 ) in the hole injection and transport region includes one or more materials selected from the group consisting of thiophene derivatives, tricyclic or more cyclic fused aromatic derivatives, amine derivatives excluding the compound represented by the following formula (A), conductive polymers, CF x , CuPc, transition metal oxides, fullerenes and acceptor materials, and a layer in the electron injection and transport region includes a benzimidazole derivative.
• US9174938B2
  申请人：——

  公开号：US9174938B2

  公开（公告）日：2015-11-03