1-(7-methyl-2,3,5,6,7,11c-hexahydro-1H-pyrido[3',2':4,5]pyrrolo[2,3-g]indolizin-9-yl)-4-(6-(trifluoromethyl)pyridin-3-yl)pyridin-2(1H)-one hydrochloride | 1260239-78-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 1-(7-methyl-2,3,5,6,7,11c-hexahydro-1H-pyrido[3',2':4,5]pyrrolo[2,3-g]indolizin-9-yl)-4-(6-(trifluoromethyl)pyridin-3-yl)pyridin-2(1H)-one hydrochloride
• 英文别名: 1-(10-Methyl-6,10,12-triazatetracyclo[7.7.0.02,6.011,16]hexadeca-1(9),11(16),12,14-tetraen-13-yl)-4-[6-(trifluoromethyl)pyridin-3-yl]pyridin-2-one;hydrochloride
• CAS: 1260239-78-8
• 化学式: C₂₅H₂₂F₃N₅O*ClH
• 分子量: 501.939
• InChiKey: SXPHRXBZZLBFML-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.92
• 重原子数：
  35
• 可旋转键数：
  2
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  54.3
• 氢给体数：
  1
• 氢受体数：
  7

文献信息

• AZINONE-SUBSTITUTED AZAPOLYCYCLE MCH-1 ANTAGONISTS, METHODS OF MAKING, AND USE THEREOF
  申请人：GUZZO Peter R.

  公开号：US20110003738A1

  公开（公告）日：2011-01-06

  Novel MCH-1 receptor antagonists are disclosed. These compounds are used in the treatment of various disorders, including obesity, anxiety, depression, non-alcoholic fatty liver disease, and psychiatric disorders. Methods of making these compounds are also described in the present invention.

  揭示了新型MCH-1受体拮抗剂。这些化合物用于治疗各种疾病，包括肥胖、焦虑、抑郁、非酒精性脂肪肝病和精神疾病。本发明还描述了制备这些化合物的方法。
• Pesticidal arylpyrrolidines
  申请人：Görgens Ulrich

  公开号：US20100216792A1

  公开（公告）日：2010-08-26

  The invention is directed to arylpyrrolidines compounds which exhibit excellent insecticidal efficacy and which may be used as in the agrochemical field or in the field of veterinary medicine. The compounds are represented by formula (I): wherein the respective substituents are defined in the specification.

  该发明涉及具有优异杀虫功效的芳基吡咯烷化合物，可以用于农药领域或兽医药领域。该化合物由式(I)表示：其中各自的取代基在说明书中定义。
• Pesticidal Arylpyrrolidines
  申请人：Bayer Intellectual Property GmbH

  公开号：US20130310408A1

  公开（公告）日：2013-11-21

  The invention is directed to arylpyrrolidines compounds which exhibit excellent insecticidal efficacy and which may be used as in the agrochemical field or in the vield of veterinary medicine. The compounds are represented by formula (I): wherein the respective substituents are defined in the specification.

  这项发明涉及一种芳基吡咯烷化合物，具有出色的杀虫功效，可用于农药领域或兽医药物领域。该化合物由式（I）表示：其中各个取代基在说明书中有定义。
• Pressure-sensitive adhesive tape or sheet
  申请人：Nitto Denko Corporation

  公开号：EP2452990A1

  公开（公告）日：2012-05-16

  The present invention relates to a pressure-sensitive adhesive tape or sheet comprising: a viscoelastic layer containing bubbles and/or fine particles; and a pressure-sensitive adhesive layer formed on at least one side of the viscoelastic layer and formed from a pressure-sensitive adhesive composition comprising a monomer mixture comprising the following (a1), (a2) and (a3) or partially polymerized product thereof, and thermal-expandable fine particles: (a1) alkyl (meth)acrylate monomer having 4 to 12 carbon atoms in its alkyl moiety and having a glass transition temperature when formed into a homopolymer of lower than 0°C; (a2) monomer having at least one nitrogen atom and one ethylenically unsaturated bond in its molecule; and (a3) monomer having one ethylenically unsaturated bond in its molecule and having a glass transition temperature when formed into a homopolymer of 0°C or higher (excluding (a2) above).

  本发明涉及一种压敏胶带或胶片，其包括：含有气泡和/或细小颗粒的粘弹性层；以及至少在粘弹性层一侧形成的压敏胶层，该层由压敏胶组合物形成，该组合物包括由下列单体混合物组成的(a1)、(a2)和(a3)或其部分聚合产物，以及可热膨胀的细小颗粒： (a1) (甲基)丙烯酸烷基单体，其烷基中含有 4 至 12 个碳原子，形成均聚物时的玻 璃转变温度低于 0°C； (a2) 分子中至少有一个氮原子和一个乙烯不饱和键的单体；以及 (a3) 分子中含有一个乙烯不饱和键，且形成均聚物时玻璃化转变温度为 0℃或以上的单体（不包括上述(a2)）。
• PESTICIDAL ARYLPYRROLIDINES
  申请人：Bayer Intellectual Property GmbH

  公开号：EP3095780A1

  公开（公告）日：2016-11-23

  The invention is directed to arylpyrrolidines compounds which exhibit excellent insecticidal efficacy and which may be used as in the agrochemical field or in the vield of veterinary medicine. The compounds are represented by formula (I): wherein the respective substituents are defined in the specification.

  本发明涉及芳基吡咯烷类化合物，这些化合物具有优异的杀虫效果，可用于农用化学品领域或兽医领域。这些化合物由式 (I) 表示： 其中各取代基在说明书中定义。