(Z)-N-[1-[(cyclopropylamino)carbonyl]-2-phenylethenyl]benzamide | 1352221-01-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (Z)-N-[1-[(cyclopropylamino)carbonyl]-2-phenylethenyl]benzamide
• 英文别名: N-[(Z)-1-(cyclopropylcarbamoyl)-2-phenylvinyl]benzamide；N-[(Z)-3-(cyclopropylamino)-3-oxo-1-phenylprop-1-en-2-yl]benzamide
• CAS: 1352221-01-2
• 化学式: C₁₉H₁₈N₂O₂
• 分子量: 306.364
• InChiKey: XQYZRPGANAHXKM-LGMDPLHJSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  23
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.16
• 拓扑面积：
  58.2
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  环丙胺 、 (4Z)-4-benzylidene-2-phenyl-1,3-oxazol-5(4H)-one 以 乙二醇 为溶剂， 反应 0.08h， 以80%的产率得到(Z)-N-[1-[(cyclopropylamino)carbonyl]-2-phenylethenyl]benzamide
  参考文献：
  名称：

  微波辐射下多取代苯甲酰胺衍生物的合成

  摘要：

  微波辅助合成N -[（Z）-1-（取代的氨基甲酰基）-2-芳基乙烯基]苯甲酰胺衍生物的简便方法是通过4-芳基亚甲基-2-苯基恶唑-5（4 H）-1与不同的胺反应来完成的（例如甲胺，环丙胺，对甲苯胺，苯胺）在乙二醇中。该方案扩大了合成N-苯甲酰胺衍生物的反应范围。

  DOI：

  10.1002/cjoc.201180326

文献信息

• New oxazolinone compounds useful as intermediates for the preparation of insecticidal and acaracidal cinnamide compounds
  申请人：AMERICAN CYANAMID COMPANY

  公开号：EP0274546A1

  公开（公告）日：1988-07-20

  The present invention relates to novel cinna­mamide compounds and oxazolinone compounds and processes for the preparation thereof. The compounds of the invention are useful for controlling insects and acarina and the oxazolinone also are useful intermediates in the prepa­ration of the cinnamamide insecticides and acaricides.

  本发明涉及新型肉桂酰胺化合物和噁唑烷酮化合物以及其制备方法。该发明的化合物对控制昆虫和螨虫具有用途，而噁唑烷酮也是肉桂酰胺类杀虫剂和螨虫剂的制备中间体。
• Methods and compositions containing pesticides and stilbene compounds for enhanced pesticidal activity
  申请人：AMERICAN CYANAMID COMPANY

  公开号：EP0568731A1

  公开（公告）日：1993-11-10

  The present invention describes a composition for enhanced pesticidal activity comprising a pesticide or a mixture of pesticides and a potentiating amount of a stilbene compound. This invention further describes a method for enhancing pesticide toxicity against an insect, an acarina, a mollusk or a nematode which employs the sequential or concurrent application of a pesticide and a stilbene compound.

  本发明描述了一种增强杀虫活性的组合物，该组合物包含一种杀虫剂或杀虫剂混合物和一种增效量的二苯乙烯化合物。本发明进一步描述了一种增强杀虫剂对昆虫、金针虫、软体动物或线虫毒性的方法，该方法采用了连续或同时施用杀虫剂和石蒜烯化合物的方法。
• α-amino acrylate microbicide, and preparation method therefor and uses thereof
  申请人：NANKAI UNIVERSITY

  公开号：US11166460B2

  公开（公告）日：2021-11-09

  The present invention relates to a microbicidal α-amino acrylic derivative and its preparation method and applications. Based on the principle of pesticide molecular design, the structural reform of the agricultural anti-plant virus activity is carried on lead compounds having the medical anti-coronavirus activity, and a series of α-amino acrylic derivatives are designed and synthesized, and in particular, α-amino acrylic derivatives containing piperidine rings are synthesized, and the systematic biological activity screening is carried by using known compounds as positive control compounds, which provide many effective anti-virus leading molecules for the preparation of pesticides, and has positive significance to reduce the pesticide application dosage and protect the environment and ecology.

  本发明涉及一种杀微生物的α-氨基丙烯酸衍生物及其制备方法和应用。根据农药分子设计原理，对具有医用抗柯洛病毒活性的先导化合物进行农业抗植物病毒活性的结构改造，设计合成了一系列α-氨基丙烯酸衍生物，特别是合成了含有哌啶环的α-氨基丙烯酸衍生物、并以已知化合物为阳性对照化合物进行了系统的生物活性筛选，为农药制备提供了多种有效的抗病毒先导分子，对减少农药用量、保护环境和生态具有积极意义。
• a-Amino Acrylate microbicide, and preparation method therefor and uses thereof
  申请人：NANKAI UNIVERSITY

  公开号：US20200236935A1

  公开（公告）日：2020-07-30

  The present invention relates to a microbicidal α-amino acrylic derivative and its preparation method and applications. Based on the principle of pesticide molecular design, the structural reform of the agricultural anti-plant virus activity is carried on lead compounds having the medical anti-coronavirus activity, and a series of α-amino acrylic derivatives are designed and synthesized, and in particular, α-amino acrylic derivatives containing piperidine rings are synthesized, and the systematic biological activity screening is carried by using known compounds as positive control compounds, which provide many effective anti-virus leading molecules for the preparation of pesticides, and has positive significance to reduce the pesticide application dosage and protect the environment and ecology.
• US4659857A
  申请人：——

  公开号：US4659857A

  公开（公告）日：1987-04-21