(+/-)-7-benzyloxy-6-methoxy-1-(3,4-dimethoxybenzyl)-1,2,3,4-tetrahydroisoquinoline | 59444-68-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异喹啉及其衍生物
• 英文名称: (+/-)-7-benzyloxy-6-methoxy-1-(3,4-dimethoxybenzyl)-1,2,3,4-tetrahydroisoquinoline
• 英文别名: O-Benzyl-N-Norcodamin；1-(3',4'-Dimethoxybenzyl)-6-methoxy-7-benzyloxy-1,2,3,4-tetrahydroisoquinoline；7-benzyloxy-1-(3,4-dimethoxy-benzyl)-6-methoxy-1,2,3,4-tetrahydro-isoquinoline；7-benzyloxy-6-methoxy-1-veratryl-1,2,3,4-tetrahydro-isoquinoline；7-Benzyloxy-6-methoxy-1-veratryl-1,2,3,4-tetrahydro-isochinolin；1-(3,4-Dimethoxy-benzyl)-7-benzyloxy-6-methoxy-1,2,3,4-tetrahydroisoquinoline；1-[(3,4-dimethoxyphenyl)methyl]-6-methoxy-7-phenylmethoxy-1,2,3,4-tetrahydroisoquinoline
• CAS: 59444-68-7
• 化学式: C₂₆H₂₉NO₄
• 分子量: 419.521
• InChiKey: RZUZZVWHTNDQOV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  31
• 可旋转键数：
  8
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  49
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  (+/-)-7-benzyloxy-6-methoxy-1-(3,4-dimethoxybenzyl)-1,2,3,4-tetrahydroisoquinoline 在 盐酸 作用下， 以 水 为溶剂， 反应 4.0h， 生成 govanine
  参考文献：
  名称：

  Bhakuni, D. S.; Kumar, Praveen, Journal of the Indian Chemical Society, 1988, vol. 65, p. 417 - 421

  摘要：

  DOI：
• 作为产物：
  描述：

  7-benzyloxy-6-methoxy-1-veratryl-3,4-dihydro-isoquinoline; hydrochloride 在 sodium tetrahydroborate 作用下， 以 甲醇 为溶剂， 反应 1.0h， 以91.4%的产率得到(+/-)-7-benzyloxy-6-methoxy-1-(3,4-dimethoxybenzyl)-1,2,3,4-tetrahydroisoquinoline
  参考文献：
  名称：

  Hara, Hiroshi; Hosaka, Machiko; Hoshino, Osamu, Journal of the Chemical Society. Perkin transactions I, 1980, p. 1169 - 1175

  摘要：

  DOI：

文献信息

• 1,2,3,4-tetrahydroisoquinoline derivatives
  申请人：——

  公开号：US20030176415A1

  公开（公告）日：2003-09-18

  The invention relates to novel 1,2,3,4-tetrahydroisochinoline derivatives of formula (I) and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing one or more of those compounds and especially their use as orexin receptor antagonists.

  本发明涉及新型1,2,3,4-四氢异喹啉衍生物的公式（I），以及它们作为药物组分在制备药物组合物中的使用。本发明还涉及相关方面，包括制备该化合物的过程，含有其中一种或多种化合物的药物组合物，特别是它们作为促进睡眠的药物组分。
• 1,2,3,4-tetrahydroisoquinolines derivatives
  申请人：——

  公开号：US20040242564A1

  公开（公告）日：2004-12-02

  The invention relates to novel 1,2,3,4-tetrahydroisoquinoline derivatives and related compounds and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing one or more of those compounds and especially their use as neurohormonal antagonists.

  本发明涉及新型1,2,3,4-四氢异喹啉衍生物及相关化合物，以及它们作为制备药物组成部分的活性成分的用途。本发明还涉及相关方面，包括制备化合物的过程，含有其中一种或多种化合物的药物组成物，特别是它们作为神经荷尔蒙拮抗剂的用途。
• 1 2 3 4 Tetrahydroisoquinolines derivatives as urotensin II receptor antagonists
  申请人：——

  公开号：US20040110744A1

  公开（公告）日：2004-06-10

  The invention relates to novel 1,2,3,4-tetrahydroisoquinoline derivatives of formula (I) and related compounds and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing one or more of those compounds and especially their use as neurohormonal antagonists especially urotensin II antagonists.

  本发明涉及一种新型1,2,3,4-四氢异喹啉衍生物的公式(I)及其相关化合物，以及它们作为制备药物组成部分的活性成分的用途。本发明还涉及相关方面，包括制备化合物的过程，含有其中一种或多种化合物的药物组合物，尤其是它们作为神经激素拮抗剂，特别是尿激肽II拮抗剂的用途。
• Formation and Reaction of o-Quinol Acetates of N-Acyl- and N-Methanesulfonyl-1,2,3,4-tetrahydro-6-methoxyisoquinolin-7-ols
  作者：Osamu Hoshino、Masaji Suzuki、Hiromichi Ogasawara

  DOI：10.3987/com-99-s84

  日期：——

  Oxidation of N-formyl-, N-acetyl-, N-ethoxycarbonyl-, and N-methanesulfonyl-1,2,3,4-tetrahydro-6-methoxyisoquinolin-7-ols (1b-e) with lead tetraacetate in dichloromethane (CH2Cl2) produced quantitatively corresponding o-quinol acetates (2b-e), treatment of which with trifluoroacetic acid in CH2Cl2 at 0 degrees C for a few minutes afforded corresponding N-acyl- and N-methanesulfonyl-wilsonirines (4b-e) and N-acyl- and N-methanesulfonylnorsebiferines (5b-e). When the reaction was carried out at room temperature, o-quinol acetates (2d,e) of N-ethoxycarbonyl and N-methanesulfonyl congeners (Id,e) gave 1-[2(ethoxycarbonylamino)ethyl]- and 1-[2-(methanesulfonylamino)ethyl]-4-hydroxy-3,6,7-trimethoxyphenanthrenes (8d,e).
• Arumugam et al., Chemische Berichte, 1958, vol. 91, p. 40,44
  作者：Arumugam et al.

  DOI：——

  日期：——