2,4-dihydroxybenzene sulphonylchloride | 134479-01-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2,4-dihydroxybenzene sulphonylchloride
• 英文别名: 2,4-Dihydroxybenzene-1-sulfonyl chloride；2,4-dihydroxybenzenesulfonyl chloride
• CAS: 134479-01-9
• 化学式: C₆H₅ClO₄S
• mdl: MFCD19200280
• 分子量: 208.622
• InChiKey: KUAHBCIONJMJKI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  83
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2,4-dihydroxybenzene sulphonylchloride 、 p,p'-bis(2-amino-1,3,4-thiadiazol-5-yl-methylamino)diphenyl sulphone 在 吡啶 作用下， 以56%的产率得到N-[5-[[4-[4-[[5-[(2,4-dihydroxyphenyl)sulfonylamino]-1,3,4-thiadiazol-2-yl]methylamino]phenyl]sulfonylanilino]methyl]-1,3,4-thiadiazol-2-yl]-2,4-dihydroxybenzenesulfonamide
  参考文献：
  名称：

  Vikani; Parekh, Journal of the Indian Chemical Society, 1990, vol. 67, # 10, p. 859 - 861

  摘要：

  DOI：

文献信息

• [EN] NOVEL SUBSTITUTED PIPERIDONES AS HSP INDUCERS<br/>[FR] NOUVELLES PIPÉRIDONES SUBSTITUÉES EN TANT QU'INDUCTEURS DE HSP
  申请人：TORRENT PHARMACEUTICALS LTD

  公开号：WO2009004650A1

  公开（公告）日：2009-01-08

  The present invention relates to novel compounds of formula (I) or (II), their pharmaceutically acceptable salts and their hydrates, solvates, stereoisomers, conformers, tautomers, polymorphs and prodrugs and also pharmaceutically acceptable compositions containing them Wherein R1, R2, R3, R4, R5, R6 and R7 are as defined in the specification. The compounds of the present invention are HSP inducers and by virtue of this effect, useful for the treatment of various diseases accompanying pathological stress. The present invention also relates to a process for the preparation of the said novel compounds. The invention also relates to the use of the above-mentioned compounds for the preparation of medicament for use as pharmaceuticals.

  本发明涉及式(I)或(II)的新化合物，它们的药学上可接受的盐及其水合物、溶剂合物、立体异构体、构象异构体、互变异构体、多晶型和前药，以及含有它们的药学上可接受的组合物，其中R1、R2、R3、R4、R5、R6和R7如规范中所定义。本发明的化合物是HSP诱导剂，由于这种作用，对于治疗伴随病理性压力的各种疾病是有用的。本发明还涉及一种制备上述新化合物的方法。该发明还涉及上述化合物的用途，用于制备用作药物的药物。
• Novel Substituted Piperidones as HSP Inducers
  申请人：Kumar Prabhat

  公开号：US20100190824A1

  公开（公告）日：2010-07-29

  The present invention relates to novel compounds of formula (I) or (II), their pharmaceutically acceptable salts and their hydrates, solvates, stereoisomers, conformers, tautomers, polymorphs and prodrugs and also pharmaceutically acceptable compositions containing them Wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 and R 7 are as defined in the specification. The compounds of the present invention are HSP inducers and by virtue of this effect, useful for the treatment of various diseases accompanying pathological stress. The present invention also relates to a process for the preparation of the said novel compounds. The invention also relates to the use of the above-mentioned compounds for the preparation of medicament for use as pharmaceuticals.

  本发明涉及公式(I)或(II)的新型化合物，它们的药学上可接受的盐、水合物、溶剂物、立体异构体、构象异构体、互变异构体、多晶型和前药，以及包含它们的药学上可接受的组合物，其中R1、R2、R3、R4、R5、R6和R7如规范中所定义。本发明的化合物是HSP诱导剂，由于这种效应，对于治疗伴随病理应激的各种疾病有用。本发明还涉及制备所述新型化合物的方法。本发明还涉及上述化合物用于制备用作药物的制剂的用途。
• Synthesis and SAR study of N-(4-hydroxy-3-(2-hydroxynaphthalene-1-yl)phenyl)-arylsulfonamides: Heat shock protein 90 (Hsp90) inhibitors with submicromolar activity in an in vitro assay
  作者：Thota Ganesh、Pahk Thepchatri、Lian Li、Yuhong Du、Haian Fu、James P. Snyder、Aiming Sun

  DOI：10.1016/j.bmcl.2008.08.022

  日期：2008.9

  Heat shock protein 90 is emerging as an important target in cancer chemotherapy. In a program directed toward identifying novel chemical probes for Hsp90, we found N-(4-hydroxy-3-(2-hydroxynaphthalene-1-yl)phenyl)benzene sulfonamide as an Hsp90 inhibitor with very weak activity. In this report, we present a new and general method for the synthesis of a variety of analogs around this scaffold, and discuss their structure-activity relationships. (C) 2008 Elsevier Ltd. All rights reserved.
• VIKANI, H. J.;PAREKH, HANSA, J. INDIAN CHEM. SOC., 67,(1990) N0, C. 859-861
  作者：VIKANI, H. J.、PAREKH, HANSA

  DOI：——

  日期：——
• NOVEL SUBSTITUTED PIPERIDONES AS HSP INDUCERS
  申请人：Torrent Pharmaceuticals Ltd

  公开号：EP2178835A1

  公开（公告）日：2010-04-28