(3,3-dimethyl-butyl)-hydrazine | 887591-69-7

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: (3,3-dimethyl-butyl)-hydrazine
• 英文别名: tertbutylethylazine；(3,3-Dimethylbutyl)hydrazine；3,3-dimethylbutylhydrazine
• CAS: 887591-69-7
• 化学式: C₆H₁₆N₂
• 分子量: 116.206
• InChiKey: DRWOEUQOFFPLQC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  8
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  38
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (3,3-dimethyl-butyl)-hydrazine 、 4-(4-chloro-6-(thiophen-2-yl)-1,3,5-triazin-2-yl)morpholine 在 potassium carbonate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 16.0h， 以68%的产率得到4-morpholino-6-(thiophen-2-yl)-N-(3,3,3-trifluoropropyl)-1,3,5-triazin-2-amine
  参考文献：
  名称：

  新型杂芳基取代的吗啉标记的三嗪的合成及其细胞毒性活性的评价

  摘要：

  背景：在本研究中，新合成的三嗪衍生物3、4、5、6、8和10由容易获得的氰尿酰氯1经吗啉进行亲核取代，然后经Suzuki或Stille偶联反应，然后热取代氯原子而合成与各种取代的胺。 方法：筛选所有合成的化合物对HT-29，MDA-MB-231和HEK293细胞系的细胞毒活性。 结果与结论：化合物6a（HT50的IC50（µM）：0.32，MDA-MB-231为2.92）和化合物8c（IC50（µM）：HT-29为1.40，MDA-MB-231为1.60）。鉴定并与阿霉素和ZSTK474作参考标准进行比较。

  DOI：

  10.2174/1570180814666170605115335

文献信息

• PYRAZOLE COMPOUND
  申请人：Sasaki Izumi

  公开号：US20130116296A1

  公开（公告）日：2013-05-09

  The present invention relates to a novel serotonin reuptake inhibitor which also exhibits 5-HT 2C antagonistic action (antidepressive and anxiolytic effects), in particular, 5-HT 2C inverse agonistic action comprising Compound (1): or a pharmaceutically acceptable salt thereof wherein R 1 , R 2 , R 3 and R 4 are independently hydrogen or C 1-6 alkyl etc.; R 5 is C 4-7 alkyl or —(CR 8 R 9 ) r -E; R 6 , R 7 , R 8 and R 9 are independently hydrogen, fluorine or C 1-6 alkyl; A is C 6-10 aryl or heteroaryl etc.; r is 1, 2, 3 or 4; E is C 3-8 cycloalkyl or C 6-10 aryl etc.; L is oxygen, sulfur or —NR 10 —; n is 1, 2 or 3; R 10 is hydrogen or C 1-6 alkyl etc.; and X is hydrogen or halogen etc.

  本发明涉及一种新型的血清素再摄取抑制剂，同时还表现出5-HT2C拮抗作用（抗抑郁和抗焦虑效果），特别是包括化合物（1）的5-HT2C逆作动作：或其药学上可接受的盐，其中R1、R2、R3和R4独立地为氢或C1-6烷基等；R5为C4-7烷基或—(CR8R9)r-E；R6、R7、R8和R9独立地为氢、氟或C1-6烷基；A为C6-10芳基或杂环芳基等；r为1、2、3或4；E为C3-8环烷基或C6-10芳基等；L为氧、硫或—NR10—；n为1、2或3；R10为氢或C1-6烷基等；X为氢或卤素等。
• THERAPEUTIC AGENT FOR NON-MOTOR SYMPTOMS ASSOCIATED WITH PARKINSON'S DISEASE
  申请人：Sumitomo Dainippon Pharma Co., Ltd.

  公开号：EP3569233A1

  公开（公告）日：2019-11-20

  The purpose of the present invention is to provide: a therapeutic agent or a recurrence preventive agent for serotonergic system- or dopaminergic system-related diseases, in particular, mental dysfunction symptoms and other non-motor symptoms of Parkinson's disease; and a method for treating the aforesaid symptoms or preventing the recurrence of the same. A compound represented by formula (1) [wherein each symbol is as defined in the description] or a pharmaceutically acceptable salt thereof can exhibit an effect of treating serotonergic system- or dopaminergic system-related diseases, in particular, mental dysfunction symptoms and other non-motor symptoms of Parkinson's disease and/or an effect of preventing the recurrence of the same.

  本发明的目的是提供：一种治疗5-羟色胺能系统或多巴胺能系统相关疾病，特别是帕金森病的精神功能障碍症状和其他非运动症状的治疗剂或复发预防剂；以及一种治疗上述症状或预防上述症状复发的方法。由式(1)代表的化合物[其中各符号如描述中所定义]或其药学上可接受的盐可以显示出治疗血清素能系统或多巴胺能系统相关疾病的效果，特别是精神功能障碍症状和帕金森病的其他非运动症状，和/或防止其复发的效果。
• Pyrazole compound
  申请人：Sumitomo Dainippon Pharma Co., Ltd.

  公开号：US10183913B2

  公开（公告）日：2019-01-22

  The present invention relates to a novel serotonin reuptake inhibitor which also exhibits 5-HT2C antagonistic action (antidepressive and anxiolytic effects), in particular, 5-HT2C inverse agonistic action comprising Compound (1): or a pharmaceutically acceptable salt thereof wherein R1, R2, R3 and R4 are independently hydrogen or C1-6 alkyl etc.; R5 is C4-7 alkyl or —(CR8R9)r-E; R6, R7, R8 and R9 are independently hydrogen, fluorine or C1-6 alkyl; A is C6-10 aryl or heteroaryl etc.; r is 1, 2, 3 or 4; E is C3-8 cycloalkyl or C6-10 aryl etc.; L is oxygen, sulfur or —NR10—; n is 1, 2 or 3; R10 is hydrogen or C1-6 alkyl etc.; and X is hydrogen or halogen etc.

  本发明涉及一种新型血清素再摄取抑制剂，它还具有 5-HT2C 拮抗作用（抗抑郁和抗焦虑作用），特别是 5-HT2C 反激动作用，由化合物（1）组成： 或其药学上可接受的盐 其中 R1、R2、R3 和 R4 独立地为氢或 C1-6 烷基等；R5 为 C4-7 烷基或-(CR8R9)r-E；R6、R7、R8 和 R9 独立地为氢、氟或 C1-6 烷基；A 为 C6-10 芳基或杂芳基等。r为 1、2、3 或 4；E 为 C3-8 环烷基或 C6-10 芳基等；L 为氧、硫或-NR10-；n 为 1、2 或 3；R10 为氢或 C1-6 烷基等；X 为氢或卤素等。
• PHOSPHADIAZINE HCV POLYMERASE INHIBITORS III AND VI
  申请人：Dousson Cyril

  公开号：US20090060867A1

  公开（公告）日：2009-03-05

  Provided herein are phosphadiazine polymerase inhibitor, for example, of Formula III, pharmaceutical compositions comprising the compounds, and processes of preparation thereof. Also provided are methods of their use for the treatment of an HCV infection in a host in need thereof.
• AMINE-CONTAINING LIPIDOIDS AND USES THEREOF
  申请人：Massachusetts Institute of Technology

  公开号：US20160114042A1

  公开（公告）日：2016-04-28

  Provided herein are lipidoids that may be prepared from the conjugate addition of alkylamines to acrylates. In some embodiments, provided lipidoids are biodegradable and may be used in a variety of drug delivery systems. Given the amino moiety of the lipidoids, they are well-suited for the delivery of polynucleotides, in addition to other agents. Nanoparticles containing the inventive lipidoids and polynucleotides have been prepared and have been shown to be effective in delivering siRNA.