3-(2-chloro-nicotinoylamino)-benzoic acid | 57842-02-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-(2-chloro-nicotinoylamino)-benzoic acid
• 英文别名: 3-[(2-Chloropyridine-3-carbonyl)amino]benzoic acid
• CAS: 57842-02-1
• 化学式: C₁₃H₉ClN₂O₃
• mdl: MFCD13197343
• 分子量: 276.679
• InChiKey: VRSUUTAGWAGAPW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  19
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  79.3
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• NOVEL TRICYCLIC DERIVATIVE OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF, PREPARATION METHOD THEREOF, AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME
  申请人：Kim Myung-Hwa

  公开号：US20110218193A1

  公开（公告）日：2011-09-08

  The present invention relates to a novel tricyclic derivative with efficient inhibitory activity against poly(ADP-ribose)polymerases (PARP) or pharmaceutically acceptable salts thereof, a preparation method thereof, and a pharmaceutical composition containing the same. The tricyclic derivative of the invention is useful for the prevention or treatment of diseases caused by excess PARP activity, especially neuropathic pain, neurodegenerative diseases, cardiovascular diseases, diabetic nephropathy, inflammatory diseases, osteoporosis, and cancer, by inhibiting the activity of poly(ADP-ribose)polymerases.

  本发明涉及一种新型三环衍生物，具有高效的抑制聚(ADP-核糖)聚合酶（PARP）或其药用可接受盐的活性，以及其制备方法和含有该衍生物的药物组合物。本发明的三环衍生物通过抑制聚(ADP-核糖)聚合酶的活性，对于预防或治疗由过度PARP活性引起的疾病特别有效，包括神经病痛、神经退行性疾病、心血管疾病、糖尿病肾病、炎症性疾病、骨质疏松症和癌症。
• Novel Acylaminobenzamide Derivatives
  申请人：Mihara Jun

  公开号：US20110201603A1

  公开（公告）日：2011-08-18

  The present invention relates to novel Acylaminobenzamide derivatives represented by the following formula (I) and use thereof as pesticides: wherein V represents an aromatic ring group of V1 to V5 described in the detailed description, Q represents an aromatic ring group of Q1 to Q7 described in the detailed description, G 1 and G 2 represent O or S, R 1 represents hydrogen, alkyl, haloalkyl, alkoxy, haloalkoxy, phenyl or a heterocyclic group and R 2 and R 3 represent hydrogen, alkyl, haloalkyl, alkylcarbonyl, haloalkylcarbonyl, alkoxycarbonyl or haloalkoxycarbonyl.

  本发明涉及一种新型的Acylaminobenzamide衍生物，其化学式如下（I），以及其作为杀虫剂的用途：其中V代表详细描述中的V1至V5的芳香环基团，Q代表详细描述中的Q1至Q7的芳香环基团，G1和G2代表O或S，R1代表氢、烷基、卤代烷基、烷氧基、卤代烷氧基、苯基或杂环基，R2和R3代表氢、烷基、卤代烷基、烷基羰基、卤代烷基羰基、烷氧基羰基或卤代烷氧基羰基。
• METHOD FOR PRODUCING AMIDE DERIVATIVE
  申请人：Mitsui Chemicals Agro, Inc.

  公开号：EP2322502A1

  公开（公告）日：2011-05-18

  An amide derivative represented by Formula (3), which exhibits excellent efficacy in pest control effect, is produced by allowing a compound represented by the following Formula (1) and a compound represented by Formula (2) to react with each other. In Formula (1) to Formula (3), Y1 and Y2 each represent a halogen atom or a haloalkyl group; Rf represents a C3-C4 perfluoroalkyl group; and R1 and R2 each represent a hydrogen atom or an alkyl group; LG represents a leaving group; T represents a hydrogen atom or a fluorine atom; X1, X3, X4, and X5 each represent a hydrogen atom, a halogen atom, or the like; and A represents a nitrogen atom, a methine group, or the like.

  下式(1)所代表的化合物与式(2)所代表的化合物相互反应，可制得式(3)所代表的酰胺衍生物，该衍生物在害虫防治效果方面具有优异功效。在式(1)至式(3)中，Y1 和 Y2 分别代表卤素原子或卤代烷基；Rf 代表 C3-C4 全氟烷基；R1 和 R2 分别代表氢原子或烷基；LG 代表离去基团；T 代表氢原子或氟原子；X1、X3、X4 和 X5 分别代表氢原子、卤素原子或类似物；A 代表氮原子、甲基或类似物。
• ACYLAMINOBENZAMIDE DERIVATIVES
  申请人：Bayer CropScience AG

  公开号：EP2318358A2

  公开（公告）日：2011-05-11
• [EN] NOVEL ACYLAMINOBENZAMIDE DERIVATIVES<br/>[FR] NOUVEAUX DÉRIVÉS D'ACYLAMINOBENZAMIDE
  申请人：BAYER CROPSCIENCE AG

  公开号：WO2010015355A2

  公开（公告）日：2010-02-11

  The present invention relates to novel Acylaminobenzamide derivatives represented by the following formula (I) and use thereof as pesticides: wherein V represents an aromatic ring group of V1 to V5 described in the detailed description, Q represents an aromatic ring group of Q1 to Q7 described in the detailed description, G1 and G2 represent O or S, R1 represents hydrogen, alkyl, haloalkyl, alkoxy, haloalkoxy, phenyl or a heterocyclic group and R2 and R3 represent hydrogen, alkyl, haloalkyl, alkylcarbonyl, haloalkylcarbonyl, alkoxycarbonyl or haloalkoxycarbonyl.