propynoic acid [cyclohexylcarbamoyl-(4-pyrrolidin-1-yl-phenyl)methyl]-(3-trifluoromethylphenyl)amide | 1201220-12-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: propynoic acid [cyclohexylcarbamoyl-(4-pyrrolidin-1-yl-phenyl)methyl]-(3-trifluoromethylphenyl)amide
• 英文别名: Ph(3-CF3)-DL-N(propioloyl)Phg(pyrrolidino)-NHcHex；N-[2-(cyclohexylamino)-2-oxo-1-(4-pyrrolidin-1-ylphenyl)ethyl]-N-[3-(trifluoromethyl)phenyl]prop-2-ynamide
• CAS: 1201220-12-3
• 化学式: C₂₈H₃₀F₃N₃O₂
• 分子量: 497.56
• InChiKey: TVWQRROCIHIYDI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.1
• 重原子数：
  36
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  52.6
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• [EN] COMPOUNDS WHICH CAN BE USED FOR THE TREATMENT OF CANCERS<br/>[FR] COMPOSÉS POUVANT ÊTRE UTILISÉS POUR LE TRAITEMENT DE CANCERS
  申请人：CYTOMICS SYSTEMS

  公开号：WO2009150248A1

  公开（公告）日：2009-12-17

  The present invention relates to a compound of general formula (I) : and also to the pharmaceutically acceptable salts thereof, to the isomers or isomer mixtures thereof in all proportions, in particular to an enantiomer mixture, and especially to a racemic mixture. The present invention also relates to the use of these compounds as a medicament, and in particular for the treatment of cancer, and also to the compositions containing them.

  本发明涉及一般式（I）的化合物，以及其药学上可接受的盐，所有比例的异构体或异构体混合物，特别是对映异构体混合物，尤其是消旋混合物。本发明还涉及将这些化合物用作药物，特别是用于癌症治疗，以及含有它们的组合物。
• Compounds which can be used for the Treatment of Cancers
  申请人：Carniato Denis

  公开号：US20110104162A1

  公开（公告）日：2011-05-05

  The present invention relates to a compound of general formula (I): and also to the pharmaceutically acceptable salts thereof, to the isomers or isomer mixtures thereof in all proportions, in particular to an enantiomer mixture, and especially to a racemic mixture. The present invention also relates to the use of these compounds as a medicament, and in particular for the treatment of cancer, and also to the compositions containing them.

  本发明涉及一般式(I)的化合物，以及其药学上可以接受的盐，所有比例的异构体或异构体混合物，特别是对映异构体混合物，尤其是外消旋混合物。本发明还涉及这些化合物作为药物的用途，特别是用于癌症治疗，以及含有它们的组合物。
• US8519188B2
  申请人：——

  公开号：US8519188B2

  公开（公告）日：2013-08-27