Tert-butyl2-amino-4-hydroxybenzoate | 2287283-59-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Tert-butyl2-amino-4-hydroxybenzoate
• 英文别名: tert-butyl 2-amino-4-hydroxybenzoate
• CAS: 2287283-59-2
• 化学式: C₁₁H₁₅NO₃
• 分子量: 209.24
• InChiKey: UPWOYQHOMTVGOM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  72.6
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• HETEROARYL COMPOUNDS AND USES THEREOF
  申请人：Celgene Avilomics Research, Inc.

  公开号：EP2635285A1

  公开（公告）日：2013-09-11
• [EN] HETEROARYL COMPOUNDS AND USES THEREOF<br/>[FR] COMPOSÉS HÉTÉROARYLE ET LEURS UTILISATIONS
  申请人：AVILA THERAPEUTICS INC

  公开号：WO2012061303A1

  公开（公告）日：2012-05-10

  Heterocyclic pynmidine compounds that modulate mutant-selective epidermal growth factor receptor (EGFR) kinase activity are disclosed. Selectivity in modulation of various EGFR mutant activity has been disclosed. Pharmaceutical compositions comprising the pynmidine derivative, and methods of treatment for diseases associated with EGFR kinase activity including non-small cell lung cancer comprising administration of the pynmidine derivative are disclosed.