N-(4-bromo-2,6-dimethylphenyl)-N'-(2,4,6-trimethylphenyl)ethane-1,2-diamineoxamide | 868961-60-8

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: N-(4-bromo-2,6-dimethylphenyl)-N'-(2,4,6-trimethylphenyl)ethane-1,2-diamineoxamide
• 英文别名: N-(4-bromo-2,6-dimethylphenyl)-N’-mesitylethane-1,2-diamine
• CAS: 868961-60-8
• 化学式: C₁₉H₂₅BrN₂
• 分子量: 361.325
• InChiKey: WGFRHZBRNZKYKF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.52
• 重原子数：
  22.0
• 可旋转键数：
  5.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.37
• 拓扑面积：
  24.06
• 氢给体数：
  2.0
• 氢受体数：
  2.0

反应信息

• 作为反应物：
  描述：

  N-(4-bromo-2,6-dimethylphenyl)-N'-(2,4,6-trimethylphenyl)ethane-1,2-diamineoxamide 在 4-二甲氨基吡啶 、 lithium aluminium tetrahydride 作用下， 以 四氢呋喃 、 N-甲基吡咯烷酮 、 二氯甲烷 为溶剂， 生成
  参考文献：
  名称：

  Biotinylated Metathesis Catalysts: Synthesis and Performance in Ring Closing Metathesis

  摘要：

  Nine biotinylated Grubbs-Hoveyda and Grubbs-type metathesis catalysts were synthesized and evaluated in ring closing metathesis reactions of N-tosyl diallylamine and 5-hydroxy-2-vinylphenyl acrylate. Their catalytic activity in organic- and aqueous solvents was compared with the second generation Grubbs-Hoveyda catalyst. The position of the biotin-moiety on the N-heterocyclic carbene was found to critically influence the catalytic activity of the corresponding ruthenium-based catalysts.

  DOI：

  10.1007/s10562-013-1179-z
• 作为产物：
  描述：

  4-溴-2,6-二甲基苯胺 在 三乙胺 作用下， 以 N-甲基吡咯烷酮 、 二氯甲烷 为溶剂， 生成 N-(4-bromo-2,6-dimethylphenyl)-N'-(2,4,6-trimethylphenyl)ethane-1,2-diamineoxamide
  参考文献：
  名称：

  Carbonic anhydrase II as host protein for the creation of a biocompatible artificial metathesase

  摘要：

  我们报告了一种高效的人工转位酶，它在蛋白质支架人类碳酸酐酶II中结合了芳基磺酰胺锚定基。

  DOI：

  10.1039/c5ob00428d

文献信息

• A Fluorescent Molecular Probe for the Detection of Hydrogen Based on Oxidative Addition Reactions with Crabtree‐Type Hydrogenation Catalysts
  作者：Pavlo Kos、Herbert Plenio

  DOI：10.1002/anie.201506918

  日期：2015.11.2

  A Crabtree‐type IrI complex tagged with a fluorescent dye (bodipy) was synthesized. The oxidative addition of H2 converts the weakly fluorescent IrI complex (Φ=0.038) into a highly fluorescent IrIII species (Φ=0.51). This fluorogenic reaction can be utilized for the detection of H2 and to probe the oxidative addition step in the catalytic hydrogenation of olefins.

  合成了带有荧光染料（bodipy）标记的Crabtree型Ir I复合物。H 2的氧化加成将弱荧光的Ir I配合物（Φ = 0.038）转换为强荧光的Ir III物种（Φ = 0.51）。该发荧光反应可用于检测H 2并探测烯烃催化加氢中的氧化加成步骤。
• Development of Building Blocks for the Synthesis of N-Heterocyclic Carbene Ligands
  作者：Guopin Xu、Scott R. Gilbertson

  DOI：10.1021/ol0516521

  日期：2005.10.1

  The synthesis of a series of NHC building blocks that can then be incorporated into more complicated structures by palladium catalysis is reported. This approach is used for the synthesis of three amino acids containing NHC side chains. The ability to use the amino acids in solid-phase peptide synthesis to make NHC-containing peptides is also demonstrated. Additionally, the NHC side chain can be deprotected and coordinated to a catalytically active transition metal. Finally, it is illustrated that the building blocks participate in Suzuki coupling to provide access to substituted NHC ligands.