methyl 2-ethoxy-4-hydroxybenzoate | 741699-00-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: methyl 2-ethoxy-4-hydroxybenzoate
• CAS: 741699-00-3
• 化学式: C₁₀H₁₂O₄
• 分子量: 196.203
• InChiKey: FCLORMUOKKFZIL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  55.8
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• AMINO ALCOHOL DERIVATIVE, MEDICINAL COMPOSITION CONTAINING THE SAME, AND USE OF THESE
  申请人：Kissei Pharmaceutical Co., Ltd.

  公开号：EP1679304A1

  公开（公告）日：2006-07-12

  The present invention provides compounds represented by general formula (I): a prodrug thereof, or pharmaceutical acceptable salts thereof, wherein R1 is hydrogen or lower alkyl; each of R2 and R3 is independently hydrogen or lower alkyl; each of R4, R5 and R6 is independently hydrogen, halogen, lower alkyl or lower alkoxy; R7 is hydrogen or lower alkyl; R8 is hydrogen, halogen, lower alkyl, lower alkoxy, etc; R9 is -COR10, -A1-COR10, -O-A2-COR10, etc; Ar is optionally substituted phenyl or heteroaryl; and A is a bond, -OCH2-, etc, which exhibit potent and selective β3-adrenoceptor stimulating activities. The present invention also provides pharmaceutical compositions containing said compound, and uses thereof.

  本发明提供了由通式（I）表示的化合物： 其前药，或其药用可接受的盐，其中R1是氢或较低的烷基；R2和R3中的每一个独立地是氢或较低的烷基；R4、R5和R6中的每一个独立地是氢、卤素、较低的烷基或较低的烷氧基；R7是氢或较低的烷基；R8是氢、卤素、较低的烷基、较低的烷氧基等；R9是-COR10、-A1-COR10、-O-A2-COR10等；Ar是可选择地取代的苯基或杂环芳基；A是键，-OCH2-等，具有强效和选择性的β3-肾上腺素受体刺激活性。本发明还提供了含有所述化合物的药物组合物，以及其用途。
• Amino alcohol derivatives, pharmaceutical compositions containing the same, and use thereof
  申请人：Kobayashi Junichi

  公开号：US20060128807A1

  公开（公告）日：2006-06-15

  The present invention provides compounds represented by general formula (I): or pharmaceutical acceptable salts thereof, wherein R 1 and R 2 are each hydrogen or lower alkyl; R 3 , R 4 , R 5 and R 6 are each hydrogen, halogen, lower alkyl or lower alkoxy; R 7 and R 8 are each hydrogen, halogen, lower alkyl, halo-lower alkyl, lower alkoxy, cycloalkyl, aryl, heteroaryl, cyano, a hydroxyl group, lower acyl, carboxy or the like; R 9 is —C(O)—R 10 , -A 1 -C(O)—R 10 , —O-A 2 -C(O)—R 10 or a tetrazol-5-yl group, which exhibit potent and selective β3-adrenoceptor stimulating activities. The present invention also provides pharmaceutical compositions containing said compound, and uses thereof.

  本发明提供一般式（I）所表示的化合物或其药学上可接受的盐，其中R1和R2均为氢或较低的烷基；R3、R4、R5和R6均为氢、卤素、较低的烷基或较低的烷氧基；R7和R8均为氢、卤素、较低的烷基、卤代较低的烷基、较低的烷氧基、环烷基、芳基、杂芳基、氰基、羟基、较低的酰基、羧基或类似物；R9为—C（O）—R10、-A1-C（O）—R10、—O-A2-C（O）—R10或四唑-5-基团，其表现出强效和选择性的β3肾上腺素能受体刺激活性。本发明还提供含有该化合物的药物组合物及其用途。
• Amino alcohol derivatives, medicinal composition containing the same, and use of these
  申请人：Kobayashi Junichi

  公开号：US20070078184A1

  公开（公告）日：2007-04-05

  The present invention provides compounds represented by general formula (I): a prodrug thereof, or pharmaceutical acceptable salts thereof, wherein R 1 is hydrogen or lower alkyl; each of R2 and R3 is independently hydrogen or lower alkyl; each of R 4 , R 5 and R 6 is independently hydrogen, halogen, lower alkyl or lower alkoxy; R 7 is hydrogen or lower alkyl; R 8 is hydrogen, halogen, lower alkyl, lower alkoxy, etc; R 9 is —COR 10 , -A 1 -COR 10 , —O-A 2 -COR 10 , etc; Ar is optionally substituted phenyl or heteroaryl; and A is a bond, —OCH 2 —, etc, which exhibit potent and selective β3-adrenoceptor stimulating activities. The present invention also provides pharmaceutical compositions containing said compound, and uses thereof.

  本发明提供了由通式（I）表示的化合物：其前体，或其药学上可接受的盐，其中R1是氢或较低的烷基；R2和R3各自独立地是氢或较低的烷基；R4，R5和R6各自独立地是氢，卤素，较低的烷基或较低的烷氧基；R7是氢或较低的烷基；R8是氢，卤素，较低的烷基，较低的烷氧基等；R9是-COR10，-A1-COR10，-O-A2-COR10等；Ar是可选取代的苯基或杂环芳基；A是键，-OCH2-等，这些化合物表现出潜在和选择性的β3-肾上腺素能受体刺激活性。本发明还提供了含有上述化合物的药物组合物及其用途。
• Modified polyester and method of manufacturing same
  申请人：POLYPLASTICS CO. LTD.

  公开号：EP0556050A1

  公开（公告）日：1993-08-18

  A modified polyester having excellent mechanical properties such as tenacity which emits only a small amount of a gas by decomposition during use at elevated temperatures for a long period of time and only a small amount of a sublimate in the course of melting it and which is suitable particularly for use as the material of a molding for an electric or electronic component, or a packaging material such as film, sheet or container, characterized by its formation from: (A) an acid component mainly comprising terephthalic acid, 2,6-naphthalenedicarboxylic acid or a lower alcohol ester thereof, (B) a diol component mainly comprising an alkylene glycol having 2 to 8 carbon atoms, and (C) an aromatic sulfonic acid compound of the following general formula (1):         (1)   HO(RO)n-Ar-SO₃M wherein Ar represents a benzene or naphthalene ring, n represents an integer from 1 to 10, R represents a group selected from among alkylenes having 2 or 3 carbon atoms and when n is 2 or more, R may be the same as or different from one another, and M represents an alkali metal selected from lithium, sodium and potassium, and satisfying the following formulae (2) and (3):         (2)   0.25 ≦ x ≦ 100 (meq/kg)         (3)   2 ≦ (x/[CEG]) x 100 ≦ 150 (%) wherein x represents the amount of the aromatic sulfonic acid compound represented by the above general formula (1) introduced thereinto and [CEG] represents the amount of the carboxy end groups, and x and [CEG] are each expressed in milliequivalent (meq/kg) per kilogram of the polymer. In a method of manufacturing the modified polyester, the said components (A), (B) and (C) are reacted together in the presence of a catalyst, component (C) preferably being added before before completion of esterification or transesterification of said acid and diol components (A) and (B).

  一种改性聚酯，具有优异的机械性能（如韧性），在高温下长期使用时仅分解释放出少量气体，在熔化过程中仅释放出少量亚硝酸盐，特别适合用作电气或电子元件的模塑材料，或薄膜、片材或容器等包装材料，其特征在于它是由以下物质形成的： (A) 酸组分，主要包括对苯二甲酸、2,6-萘二甲酸或其低级醇酯、 (B) 主要由具有 2 至 8 个碳原子的烷二醇组成的二元醇成分，以及 (C) 下述通式（1）的芳香族磺酸化合物： (1) HO(RO)n-Ar-SO₃M 其中 Ar 代表苯环或萘环、 n 代表 1 至 10 的整数、 R 代表选自具有 2 或 3 个碳原子的亚烷基中的一个基团，当 n 为 2 或 2 个以上时，R 可彼此相同或不同，以及 M 代表选自锂、钠和钾的碱金属，并满足下式（2）和（3）： (2) 0.25 ≦ x ≦ 100 (meq/kg) (3) 2 ≦ (x/[CEG]) x 100 ≦ 150 (%) 其中 x 代表引入上述通式（1）所代表的芳香族磺酸化合物的量，[CEG] 代表羧基末端基团的量，以及 x和[CEG]分别以每公斤聚合物的毫当量（meq/kg）表示。 在制造改性聚酯的方法中，所述组分（A）、（B）和（C）在催化剂存在下一起反应，组分（C）最好在所述酸和二元醇组分（A）和（B）完成酯化或酯交换之前加入。
• AMINO ALCOHOL DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME, AND USE THEREOF
  申请人：Kissei Pharmaceutical Co., Ltd.

  公开号：EP1593666B1

  公开（公告）日：2008-07-02