4-(4-羟基-3-甲氧基苯基)苯甲酸 | 189161-82-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 4-(4-羟基-3-甲氧基苯基)苯甲酸
• 英文名称: 4-(4-carboxyphenyl)-2-methoxyphenol
• 英文别名: 4-(4-hydroxy-3-methoxyphenyl)benzoic acid
• CAS: 189161-82-8
• 化学式: C₁₄H₁₂O₄
• 分子量: 244.247
• InChiKey: PIPNZBIJJWCSCS-UHFFFAOYSA-N

物化性质

• 沸点：
  431.1±35.0 °C(Predicted)
• 密度：
  1.287±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  66.8
• 氢给体数：
  2
• 氢受体数：
  4

安全信息

• 海关编码：
  2918990090

反应信息

• 作为产物：
  描述：

  4-溴邻甲氧基苯酚 、 4-甲氧羰基苯硼酸 在 palladium on activated charcoal 氢氧化钾 作用下， 以 水 为溶剂， 反应 0.25h， 以36%的产率得到4-(4-羟基-3-甲氧基苯基)苯甲酸甲酯
  参考文献：
  名称：

  An expeditious aqueous Suzuki–Miyaura method for the arylation of bromophenols

  摘要：

  The development of a novel Suzuki-Miyaura method has been achieved to allow the efficient arylation of bromophenols. A range of functionality is tolerated with,regard to the boronic acid coupling partner and the reaction exhibits complete chemoselectivity for the C-aryl-Br bond versus the C-aryl-Cl bond in the aryl halide input. The experimental protocol features a short reaction time of 15 min, utilizes inexpensive Pd/C as a catalyst, and is conducted with water as the solvent. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2006.04.027

文献信息

• An expeditious aqueous Suzuki–Miyaura method for the arylation of bromophenols
  作者：Joel S. Freundlich、Howard E. Landis

  DOI：10.1016/j.tetlet.2006.04.027

  日期：2006.6

  The development of a novel Suzuki-Miyaura method has been achieved to allow the efficient arylation of bromophenols. A range of functionality is tolerated with,regard to the boronic acid coupling partner and the reaction exhibits complete chemoselectivity for the C-aryl-Br bond versus the C-aryl-Cl bond in the aryl halide input. The experimental protocol features a short reaction time of 15 min, utilizes inexpensive Pd/C as a catalyst, and is conducted with water as the solvent. (c) 2006 Elsevier Ltd. All rights reserved.