3-(4-dimethylamino-2-nitro-benzoylamino)-4,5,6,7-tetrahydro-pyrazolo[4,3-c]pyridine-1-carboxylic acid ethyl ester hydrochloride | 942468-76-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-(4-dimethylamino-2-nitro-benzoylamino)-4,5,6,7-tetrahydro-pyrazolo[4,3-c]pyridine-1-carboxylic acid ethyl ester hydrochloride
• 英文别名: Ethyl 3-[[4-(dimethylamino)-2-nitrobenzoyl]amino]-4,5,6,7-tetrahydropyrazolo[4,3-c]pyridine-1-carboxylate;hydrochloride
• CAS: 942468-76-0
• 化学式: C₁₈H₂₂N₆O₅*ClH
• 分子量: 438.871
• InChiKey: JLIHZFYQEVBBOM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.18
• 重原子数：
  30
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.39
• 拓扑面积：
  134
• 氢给体数：
  3
• 氢受体数：
  8

文献信息

• Substituted Pyrazolo[4,3-c]Pyridine Derivatives Active as Kinase Inhibitors
  申请人：Bandiera Tiziano

  公开号：US20090023745A1

  公开（公告）日：2009-01-22

  Substituted pyrazolo[4,3-c]pyridine derivatives of formula (I) and pharmaceutically acceptable salts thereof, as defined in the specification, process for their preparation and pharmaceutical compositions comprising them are disclosed; the compounds of the invention may be useful in therapy in the treatment of diseases associated with a dysregulated protein kinase activity, like cancer.

  本发明公开了式(I)的取代吡唑并[4,3-c]吡啶衍生物及其药学上可接受的盐，其定义在规范中，以及它们的制备方法和包含它们的制药组合物；本发明的化合物可能在治疗与蛋白激酶活性失调相关的疾病，如癌症方面有用。
• SUBSTITUTED PYRAZOLO [4,3-C] PYRIDINE DERIVATIVES ACTIVE AS KINASE INHIBITORS
  申请人：NERVIANO MEDICAL SCIENCES S.r.l.

  公开号：EP1968976A1

  公开（公告）日：2008-09-17
• US8173659B2
  申请人：——

  公开号：US8173659B2

  公开（公告）日：2012-05-08
• [EN] SUBSTITUTED PYRAZOLO [4,3-C] PYRIDINE DERIVATIVES ACTIVE AS KINASE INHIBITORS<br/>[FR] DERIVES DE PYRAZOLO[4,3-C]PYRIDINE SUBSTITUES AGISSANT COMME INHIBITEURS DE KINASE
  申请人：NERVIANO MEDICAL SCIENCES SRL

  公开号：WO2007068619A1

  公开（公告）日：2007-06-21

  [EN] Substituted pyrazolo[4,3-c]pyridine derivatives of formula (I) and pharmaceutically acceptable salts thereof, as defined in the specification, process for their preparation and pharmaceutical compositions comprising them are disclosed; the compounds of the invention may be useful in therapy in the treatment of diseases associated with a dysregulated protein kinase activity, like cancer.
  [FR] L'invention concerne des dérivés de pyrazolo[4,3-c]pyridine de formule (I) et des sels de ceux-ci acceptables d'un point de vue pharmaceutique, tels que définis dans le descriptif, leur procédé de préparation et des compositions pharmaceutiques les comprenant. Les composés de cette invention peuvent être utiles en thérapie dans le traitement de maladies associées à une activité dérégulée de la protéine kinase, telles que le cancer.