5-Chloro-3-(4-methylsulfinylphenyl)-2-pyridin-3-ylpyridine | 616210-88-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 5-Chloro-3-(4-methylsulfinylphenyl)-2-pyridin-3-ylpyridine
• CAS: 616210-88-9
• 化学式: C₁₇H₁₃ClN₂OS
• 分子量: 328.822
• InChiKey: ZEYLODUXASHIQY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  22
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  62.1
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• TREATMENT OF INFLAMMATION WITH A COMBINATION OF A CYCLOOXYGENASE-2 INHIBITOR AND AN INTEGRIN ALPHA-V ANTAGONIST
  申请人：Merck & Co., Inc.

  公开号：EP1322311A1

  公开（公告）日：2003-07-02
• [EN] TREATMENT OF INFLAMMATION WITH A COMBINATION OF A CYCLOOXYGENASE-2 INHIBITOR AND AN INTEGRIN ALPHA-V ANTAGONIST<br/>[FR] TRAITEMENT DE L'INFLAMMATION AU MOYEN D'UNE COMBINAISON D'UN INHIBITEUR DE CYCLOOXYGENASE-2 ET D'UN ANTAGONISTE D'INTEGRINE ALPHA-V
  申请人：MERCK & CO INC

  公开号：WO2002022124A1

  公开（公告）日：2002-03-21

  The present invention provides for methods for treating or preventing an inflammatory disease or condition in a mammalian patient in need of such treatment comprising administering to said patient a cyclooxygenase-2 specific inhibitor in combination with an αVβ3, ?αVβ5 and/or αVβ6 integrin receptor antagonist in an amount effective to treat or prevent the inflammatory disease or condition. The present invention also provides for pharmaceutical compositions for the treatment or prevention of an inflammatory disease or condition. Further, the invention provides for the manufacture of a medicament useful in the treatment or prevention of an inflammatory disease or condition.