5-amino-2-(pyrrolidin-1'-ylmethyl)phenol | 133914-80-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 5-amino-2-(pyrrolidin-1'-ylmethyl)phenol
• 英文别名: 5-amino-2-(pyrrolidin-1-ylmethyl)phenol；5-amino-2-(pyrrolidinomethyl)phenol
• CAS: 133914-80-4
• 化学式: C₁₁H₁₆N₂O
• 分子量: 192.261
• InChiKey: GREIWYYNJXYQCD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  49.5
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  5-amino-2-(pyrrolidin-1'-ylmethyl)phenol 在 盐酸 作用下， 以 乙醇 、 水 为溶剂， 反应 29.0h， 生成 2,6-bis(pyrrolidin-1'-ylmethyl)-3-(7''-trifluoromethylquinolin-4''-ylamino)phenol
  参考文献：
  名称：

  Barlin, Gordon B.; Ireland, Stephen J.; Nguyen, Trang M. T., Australian Journal of Chemistry, 1993, vol. 46, # 11, p. 1685 - 1694

  摘要：

  DOI：
• 作为产物：
  描述：

  N-(3-hydroxy-4-pyrrolidin-1-ylmethylphenyl)acetamide 在 盐酸 、 水 作用下， 反应 6.0h， 生成 5-amino-2-(pyrrolidin-1'-ylmethyl)phenol
  参考文献：
  名称：

  [EN] 7-CHLORO-QUINOLIN-4-AMINE COMPOUNDS AND USES THEREOF FOR THE PREVENTION OR TREATMENT OF DISEASES INVOLVING FORMATION OF AMYLOID PLAQUES AND/OR WHERE A DYSFUNCTION OF THE APP METABOLISM OCCURS
  [FR] COMPOSÉS DE 7-CHLORO-QUINOLIN-4-AMINE ET LEURS UTILISATIONS POUR PRÉVENIR OU TRAITER LES MALADIES IMPLIQUANT LA FORMATION DE PLAQUES AMYLOÏDES ET/OU UN DYSFONCTIONNEMENT DU MÉTABOLISME DE L'APP

  摘要：

  本发明涉及具有以下式（I）的化合物，用于预防和/或治疗涉及淀粉样斑块形成和/或APP代谢功能障碍的疾病。

  公开号：

  WO2011073322A1

文献信息

• NEW HETEROCYCLE COMPOUNDS AND USES THEREOF FOR THE PREVENTION OR TREATMENT OF DISEASES INVOLVING FORMATION OF AMYLOID PLAQUES AND/OR WHERE A DYSFUNCTION OF THE APP METABOLISM OCCURS
  申请人：Delacourte Andre

  公开号：US20120283256A1

  公开（公告）日：2012-11-08

  The present invention relates to compounds having the following Formula (I) for use in the prevention and/or the treatment of diseases involving formation of amyloid plaques and/or where a dysfunction of the APP metabolism occurs.

  本发明涉及具有以下式（I）的化合物，用于预防和/或治疗涉及淀粉样斑块形成和/或APP代谢功能紊乱的疾病。
• Heterocycle compounds and uses thereof for the prevention or treatment of diseases involving formation of amyloid plaques and/or where a dysfunction of the APP metabolism occurs
  申请人：Delacourte Andre

  公开号：US08680095B2

  公开（公告）日：2014-03-25

  The present invention relates to compounds having the following Formula (I) for use in the prevention and/or the treatment of diseases involving formation of amyloid plaques and/or where a dysfunction of the APP metabolism occurs.

  本发明涉及以下式（I）的化合物，用于预防和/或治疗涉及淀粉样斑块形成和/或APP代谢功能障碍的疾病。
• Dye couplers
  申请人：Bristol-Myers Squibb Company

  公开号：EP0398702A2

  公开（公告）日：1990-11-22

  The present invention concerns the aminophenols (I) as novel couplers wherein R₁ and R₂ may be the same or different and are hydrogen, alkyl and hydroxyalkyl of from 1 to about 6 carbons in the alkyl moiety, or R₁ and R₂ can also form, together with the nitrogen atom to which they are attached, a morpholine, piperidine or pyrrolidine ring, and R₃ and R₄ are hydrogen, alkyl, acyl and hydroxyalkyl having from 1 to about 6 carbons, and oxidative hair dye compositions containing same along with at least one primary dye intermediate in aqueous or hydroalcoholic media.

  本发明涉及作为新型偶联剂的氨基苯酚 (I) 其中，R₁ 和 R₂ 可以相同或不同，并且是氢、烷基和烷基中 1 至 6 个碳原子的羟烷基，或者 R₁ 和 R₂ 也可以与它们所连接的氮原子一起形成吗啉环、哌啶环或吡咯烷环，而 R₃ 和 R₄ 是氢、烷基和羟烷基、R₃和 R₄是氢、烷基、酰基和羟基烷基，具有 1 至 6 个碳原子，以及在水性或水醇介质中含有至少一种主染料中间体的氧化染发组合物。
• Hair colorant assessment, selection and formulation system
  申请人：Innovative Beauty LLC

  公开号：US11137291B1

  公开（公告）日：2021-10-05

  A hair colorant selection and formulation system including one or more of a hair color analyzer operable to determine hair color of a hair sample and match the determined hair color to a color in a color space, a hair color selector operable in combination with a fiber optic hair sample to generate the color selected in a color space in the optical fibers of a fiber optic hair sample, and a hair colorant mixer which operates to mix a hair colorant, which can be individually, or in various combinations, operably coupled to one or more computing devices through one or more server computers via a network which supports a hair colorant selection and hair colorant formulation program accessible by the one or more computing devices.

  一种头发着色剂选择和配制系统，包括一个或多个头发颜色分析仪，可用于确定头发样本的头发颜色，并将确定的头发颜色与颜色空间中的颜色相匹配；一个头发颜色选择器，可与光纤头发样本相结合，在光纤头发样本的光纤中生成颜色空间中选择的颜色、以及一个染发剂混合器，该染发剂混合器用于混合染发剂，可单独或以各种组合方式通过一个或多个服务器计算机经由网络与一个或多个计算设备连接，该网络支持一个或多个计算设备可访问的染发剂选择和染发剂配制程序。
• 7-CHLORO-QUINOLIN-4-AMINE COMPOUNDS AND USES THEREOF FOR THE PREVENTION OR TREATMENT OF DISEASES INVOLVING FORMATION OF AMYLOID PLAQUES AND/OR WHERE A DYSFUNCTION OF THE APP METABOLISM OCCURS
  申请人：Institut National de la Santé et de la Recherche Médicale

  公开号：EP2513062A1

  公开（公告）日：2012-10-24