硫酸月桂酯苯海拉明 | 103659-13-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 硫酸月桂酯苯海拉明
• 英文名称: Diphenhydramine laurylsulfate
• 英文别名: 2-benzhydryloxy-N,N-dimethylethanamine;dodecyl hydrogen sulfate
• CAS: 103659-13-8
• 化学式: C29H47NO5S
• 分子量: 521.8
• InChiKey: AJZFEQIFKBZILH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.08
• 重原子数：
  36
• 可旋转键数：
  18
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.59
• 拓扑面积：
  84.4
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• Porous silica having substance carried thereon
  申请人：Kitahata Kouichi

  公开号：US20070003492A1

  公开（公告）日：2007-01-04

  The present invention relates to a substance-supporting porous silica, wherein a porous silica supports a substance selected from the group consisting of menthols, volatile substances, thermal substances, plant polyphenols and organic colorants.

  本发明涉及一种物质支持多孔硅胶，其中多孔硅胶支持从薄荷醇、挥发性物质、热性物质、植物多酚和有机染料等组成的物质。
• Novel Blt2-Mediated Disease, Blt2 Binding Agent And the Compound
  申请人：Nakade Shinji

  公开号：US20080132574A1

  公开（公告）日：2008-06-05

  [PROBLEM] The compound that selectively binds to BLT2 and the preventive and/or therapeutic drug for BLT2-mediated disease such as skin disease are needed. [MEANS FOR SOLVING THE PROBLEMS] The present invention provides the compound with BLT2 binding activity, salt thereof, solvate thereof or prodrug thereof. Since the compound with BLT2 binding activity, particularly the compound represented by the formula (I) salt thereof, solvate thereof or prodrug thereof (symbols in formula have the same meanings as specification.) have BLT2 binding activity, it is useful for prevention and/or therapy of BLT2 mediated diseases, e.g., dermatosis, intestinal disease, HIV infection, acquired immunodeficiency syndrome, rejection to transplant, transplant rejection, graft-versus-host disease, autoimmune disease, allergic disease, inflammation, infection, ulcers, lymphoma, malignant tumor, leucaemia, arterial sclerosis, hepatitis, hepatic cirrhosis or cancer, etc.

  【问题】需要一种选择性结合于BLT2的化合物和预防和/或治疗BLT2介导的疾病，如皮肤病的药物。 【解决方法】本发明提供具有BLT2结合活性的化合物，其盐，溶剂化物或前药。由于具有BLT2结合活性的化合物，特别是由式（I）表示的化合物，其盐，溶剂化物或前药（式中的符号与说明书具有相同的含义）具有BLT2结合活性，因此对于预防和/或治疗BLT2介导的疾病，例如皮肤病，肠道疾病，HIV感染，获得性免疫缺陷综合症，移植排斥，移植物排斥，移植物抗宿主病，自身免疫性疾病，过敏性疾病，炎症，感染，溃疡，淋巴瘤，恶性肿瘤，白血病，动脉硬化，肝炎，肝硬化或癌症等具有用处。
• Medical composition for external application
  申请人：Kao Corporation

  公开号：EP0179277A1

  公开（公告）日：1986-04-30

  57 A medical composition for external application comprises a dialkyl phosphate represented by the formula: wherein R, and R2 independently represent a hydrocarbon group having from 6 to 24 carbon atoms, R3 and R. independently represent hydrocarbon group having from 2 to 6 carbon atoms, m and n indepedently represent a value of from 0 to 20, and x represents a hydrogen atom or a salt of an alkali metal and the like. In the presence of the dialkyl phosphate, percutaneous intake of medically active ingredients is highly enhanced. Examples of the medically active ingredients directed to in the invention include antiinflammatory agents such as ethyl aminobenzoate; adrenocortical hormones such as hydrocortisone; etc. The inventive composition is highly safe without giving any stimulation to the skin.

  57 用于外用的医疗组合物包括由式表示的磷酸二烷基酯：其中 R 和 R2 独立地代表具有 6 至 24 个碳原子的烃基，R3 和 R.独立地代表具有 2 至 6 个碳原子的烃基，m 和 n 独立地代表 0 至 20 的值，x 代表氢原子或碱金属盐等。 在磷酸二烷基酯存在的情况下，经皮摄入医疗活性成分的效果非常好。 本发明所涉及的医疗活性成分包括抗炎剂（如氨基苯甲酸乙酯）、肾上腺皮质激素（如氢化可的松）等，本发明组合物非常安全，不会对皮肤造成任何刺激。
• Aerosol composition containing a film-forming hydroxycarboxylic acid polymer
  申请人：TAKEDA CHEMICAL INDUSTRIES, LTD.

  公开号：EP0521455A2

  公开（公告）日：1993-01-07

  The present invention relates to an aerosol composition which comprises a biodegradable hydroxycarboxylic acid polymer as a film-forming component. This aerosol composition produces the following effects, among others: (1) application to the injured site by spraying will not cause pain; (2) it is biocompatible and resists peeling off after application; (3) it is not readily dissolved in or washed away with water; and (4) it can be allowed to remain on the skin after application since it is biodegradable.

  本发明涉及一种气溶胶组合物，它由可生物降解的羟基羧酸聚合物作为成膜成分。 除其他外，这种气雾剂组合物具有以下效果：(1) 喷洒到受伤部位不会引起疼痛；(2) 具有生物相容性，喷洒后不易脱落；(3) 不易溶于水或被水冲走；(4) 由于可生物降解，喷洒后可留在皮肤上。
• EXTERNAL PREPARATIONS FOR TREATING DERMATOSES
  申请人：SEKISUI KAGAKU KOGYO KABUSHIKI KAISHA

  公开号：EP0766960A1

  公开（公告）日：1997-04-09

  The first invention provides an external preparation for treating dermatoses comprising vitamin E and squalane, which has an efficacy at least equivalent to that of external preparations containing adrenocortical hormones as the active ingredient. The second invention provides an external preparation for treating dermatoses comprising an adrenocortical hormone, vitamin E and squalane, which is reduced in adrenocortical hormone content as compared with conventional preparations, is also reduced in side effects, and has high clinical efficacy. The third invention provides an external preparation for treating dermatoses comprising a nonsteroidal antiinflammatory agent, vitamin E, and squalane and/or squalene, which is reduced in side effects and is highly efficacious. The fourth invention provides an external preparation for treating dermatoses comprising an antihistaminic agent, vitamin E, and squalane and/or squalene, which is reduced in side effects and is highly efficacious like the above preparation. The fifth invention provides an external preparation for treating dermatoses comprising vitamin E, squalene and squalane, which is reduced in side effects and is highly efficacious.

  第一项发明提供了一种用于治疗皮肤病的外用制剂，该制剂由维生素 E 和角鲨烷组成，其疗效至少相当于以肾上腺皮质激素为活性成分的外用制剂。第二项发明提供了一种治疗皮肤病的外用制剂，它由肾上腺皮质激素、维生素 E 和角鲨烷组成，与传统制剂相比，肾上腺皮质激素含量降低，副作用也减少，临床疗效高。第三项发明提供了一种治疗皮肤病的外用制剂，该制剂由非甾体抗炎剂、维生素 E 和角鲨烷和/或角鲨烯组成，副作用小，疗效显著。第四项发明提供了一种治疗皮肤病的外用制剂，该制剂由抗组胺剂、维生素 E 和角鲨烷和/或角鲨烯组成，与上述制剂一样，副作用小，疗效显著。第五项发明提供了一种治疗皮肤病的外用制剂，由维生素 E、角鲨烯和角鲨烷组成，副作用小，疗效好。