1-(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)-2-(4-chlorophenylamino)-1H-pyrimidin-4-one | 1033942-70-9

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘧啶核苷
• 英文名称: 1-(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)-2-(4-chlorophenylamino)-1H-pyrimidin-4-one
• CAS: 1033942-70-9
• 化学式: C₂₁H₂₂ClN₃O₈
• 分子量: 479.874
• InChiKey: FFYUWMZVYUOCJB-VBSBHUPXSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.96
• 重原子数：
  33.0
• 可旋转键数：
  7.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  135.05
• 氢给体数：
  1.0
• 氢受体数：
  11.0

反应信息

• 作为反应物：
  描述：

  1-(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)-2-(4-chlorophenylamino)-1H-pyrimidin-4-one 在 氨 作用下， 以 甲醇 为溶剂， 以92.5%的产率得到1-(β-D-ribofuranosyl)-2-(4-chlorophenylamino)-1H-pyrimidin-4-one
  参考文献：
  名称：

  Synthesis of N 2-Arylisocytidines and N 2-Aryl-2′-deoxyisocytidines

  摘要：

  2-(Arylamino)pyrimidin-4-ones were synthesized, silylated, and condensed with l,2,3,5-tetra-O-acetyl-beta-D-ribofuranoside to afford the corresponding N-2-aryl protected isocytidines. Deprotection of the acetylated isocytidines using saturated NH3 in MeOH solution gave 1-(beta-D-ribofuranosyl)-2-(arylamino)-4-pyrimidinones. Methyl 2-deoxy-3,5-di-O-toluyl-alpha/beta-D-ribofuranoside was prepared and condensed with the previously silylated bases to afford the anomeric mixture of protected nucleosides. The pure beta-anomers were synthesized with better yield by treating the sodium salts of N-2-arylisocytosine derivatives with 2-deoxy-3,5-di-O-toluyl-alpha-D-ribofuranosyl chloride. Deprotection of the latter anomers afforded the corresponding free hydroxyl derivatives. The synthesized free nucleosides are under antiviral and oligonucleotide investigations.

  DOI：

  10.1007/s00706-007-0671-9
• 作为产物：
  描述：

  对氯苯胺 在 ammonium sulfate 、 六甲基二硅氮烷 作用下， 以 溶剂黄146 为溶剂， 反应 10.0h， 生成 1-(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)-2-(4-chlorophenylamino)-1H-pyrimidin-4-one
  参考文献：
  名称：

  Synthesis of N 2-Arylisocytidines and N 2-Aryl-2′-deoxyisocytidines

  摘要：

  2-(Arylamino)pyrimidin-4-ones were synthesized, silylated, and condensed with l,2,3,5-tetra-O-acetyl-beta-D-ribofuranoside to afford the corresponding N-2-aryl protected isocytidines. Deprotection of the acetylated isocytidines using saturated NH3 in MeOH solution gave 1-(beta-D-ribofuranosyl)-2-(arylamino)-4-pyrimidinones. Methyl 2-deoxy-3,5-di-O-toluyl-alpha/beta-D-ribofuranoside was prepared and condensed with the previously silylated bases to afford the anomeric mixture of protected nucleosides. The pure beta-anomers were synthesized with better yield by treating the sodium salts of N-2-arylisocytosine derivatives with 2-deoxy-3,5-di-O-toluyl-alpha-D-ribofuranosyl chloride. Deprotection of the latter anomers afforded the corresponding free hydroxyl derivatives. The synthesized free nucleosides are under antiviral and oligonucleotide investigations.

  DOI：

  10.1007/s00706-007-0671-9