5-{[(Tert-butoxy)carbonyl]amino}-3-chloropyridine-2-carboxylicacid | 2097854-25-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 5-{[(Tert-butoxy)carbonyl]amino}-3-chloropyridine-2-carboxylicacid
• 英文别名: 3-chloro-5-[(2-methylpropan-2-yl)oxycarbonylamino]pyridine-2-carboxylic acid
• CAS: 2097854-25-4
• 化学式: C₁₁H₁₃ClN₂O₄
• 分子量: 272.68
• InChiKey: HNASBLATCWNGGM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  18
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  88.5
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• NOVEL PYRAZOLO PYRIMIDINE DERIVATIVES
  申请人：Novartis AG

  公开号：EP3374361A1

  公开（公告）日：2018-09-19
• Novel Pyrazolo Pyrimidine Derivatives
  申请人：Novartis AG

  公开号：US20200289514A1

  公开（公告）日：2020-09-17

  The present invention describes new pyrazolo-pyrimidine derivatives which are generally interacting with MALT1 proteolytic and/or autoproteolytic activity, and in particular which may inhibit said activity. The present invention further describes the synthesis of said new pyrazolo-pyrimidine derivatives, their use as a medicament, especially by interacting with MALT1 proteolytic and/or autoproteolytic activity.
• [EN] NOVEL PYRAZOLO PYRIMIDINE DERIVATIVES<br/>[FR] NOUVEAUX DÉRIVÉS DE PYRAZOLO-PYRIMIDINE
  申请人：NOVARTIS AG

  公开号：WO2017081641A1

  公开（公告）日：2017-05-18

  The present invention describes new pyrazolo-pyrimidine derivatives which are generally interacting with MALT1 proteolytic and/or autoproteolytic activity, and in particular which may inhibit said activity. The present invention further describes the synthesis of said new pyrazolo-pyrimidine derivatives, their use as a medicament, especially by interacting with MALT1 proteolytic and/or autoproteolytic activity.